PMID- 28454253
OWN - NLM
STAT- PubMed-not-MEDLINE
LR  - 20201001
IS  - 1792-1074 (Print)
IS  - 1792-1082 (Electronic)
IS  - 1792-1074 (Linking)
VI  - 13
IP  - 3
DP  - 2017 Mar
TI  - Expression and clinical significance of YAP in laryngeal squamous cell carcinoma 
      patients.
PG  - 1311-1314
LID - 10.3892/ol.2016.5541 [doi]
AB  - The aim of the present study was to investigate the expression levels of 
      Yes-associated protein (YAP) in different grades of laryngeal squamous cell 
      carcinoma (LSCC) tissues and vocal cord polyps tissues, and to investigate any 
      correlations with clinical factors. The expression of YAP in 128 cases of LSCC 
      and 10 cases of vocal cord polyps tissues was tested using immunohistochemistry. 
      YAP was primarily present in the nucleus of LSCC and controls, whereas 
      phosphorylated YAP expression was present in the cytoplasm. The results indicated 
      that YAP expression was upregulated in LSCC samples compared with vocal cord 
      polyps tissues. YAP expression was positively correlated with the malignant 
      degree of LSCC (P<0.01) and a high level of YAP expression in LSCC tissues was 
      correlated with pathological type, lymphatic metastasis and clinical stage. The 
      present study provided evidence for the expression and localization of YAP in 
      LSCC and vocal cord polyps tissues. Thus, YAP may be involved in the occurrence 
      and development of LSCC as an oncogene.
FAU - Qiu, Shijie
AU  - Qiu S
AD  - Department of Otorhinolaryngology (Head and Neck Surgery), Ningbo Medical Center 
      Lihuili Hospital, Ningbo, Zhejiang 315040, P.R. China.
FAU - Xia, Zhaoxia
AU  - Xia Z
AD  - Department of Otorhinolaryngology (Head and Neck Surgery), Ningbo Medical Center 
      Lihuili Hospital, Ningbo, Zhejiang 315040, P.R. China.
FAU - Li, Qun
AU  - Li Q
AD  - Department of Otorhinolaryngology (Head and Neck Surgery), Ningbo Medical Center 
      Lihuili Hospital, Ningbo, Zhejiang 315040, P.R. China.
FAU - Ye, Dong
AU  - Ye D
AD  - Department of Otorhinolaryngology (Head and Neck Surgery), Ningbo Medical Center 
      Lihuili Hospital, Ningbo, Zhejiang 315040, P.R. China.
FAU - Huang, Qi
AU  - Huang Q
AD  - Department of Otorhinolaryngology (Head and Neck Surgery), Ningbo Medical Center 
      Lihuili Hospital, Ningbo, Zhejiang 315040, P.R. China.
FAU - Shen, Zhisen
AU  - Shen Z
AD  - Department of Otorhinolaryngology (Head and Neck Surgery), Ningbo Medical Center 
      Lihuili Hospital, Ningbo, Zhejiang 315040, P.R. China.
LA  - eng
PT  - Journal Article
DEP - 20161227
PL  - Greece
TA  - Oncol Lett
JT  - Oncology letters
JID - 101531236
PMC - PMC5403389
OTO - NOTNLM
OT  - larynx squamous cell carcinoma
OT  - yes-associated protein
EDAT- 2017/04/30 06:00
MHDA- 2017/04/30 06:01
PMCR- 2016/12/27
CRDT- 2017/04/30 06:00
PHST- 2016/05/19 00:00 [received]
PHST- 2016/07/21 00:00 [accepted]
PHST- 2017/04/30 06:00 [entrez]
PHST- 2017/04/30 06:00 [pubmed]
PHST- 2017/04/30 06:01 [medline]
PHST- 2016/12/27 00:00 [pmc-release]
AID - OL-0-0-5541 [pii]
AID - 10.3892/ol.2016.5541 [doi]
PST - ppublish
SO  - Oncol Lett. 2017 Mar;13(3):1311-1314. doi: 10.3892/ol.2016.5541. Epub 2016 Dec 
      27.