PMID- 28454377
OWN - NLM
STAT- PubMed-not-MEDLINE
LR  - 20201001
IS  - 1792-1074 (Print)
IS  - 1792-1082 (Electronic)
IS  - 1792-1074 (Linking)
VI  - 13
IP  - 4
DP  - 2017 Apr
TI  - Frequent expression of human leukocyte antigen class I and the status of 
      intratumoral immune cells in alveolar soft part sarcoma.
PG  - 2169-2176
LID - 10.3892/ol.2017.5696 [doi]
AB  - The prognosis of alveolar soft part sarcoma is poor, despite the slow growth of 
      the tumor. A number of cases with spontaneous regression of this rare tumor have 
      been reported. Although the mechanisms underlying spontaneous regression remain 
      uncertain, local immune reaction may be a possible contributing factor. 
      Immunohistochemical expression of human leukocyte antigen (HLA) class I, cluster 
      of differentiation (CD) 3, CD4, CD8, CD20, CD45, CD56, CD68, CD138 and CD163 were 
      assessed in a series of 10 alveolar soft part sarcomas, and the expression 
      profiles were associated with patients' clinicopathological parameters. 
      Expression of HLA class I was observed in almost all the tumor cells of all 
      cases. CD8(+) cells were identified in all tumors with varying densities. 
      Moderate infiltration of CD8(+) cells was detected in three patients; one of 
      these patients survived with long-term tumor remission. Infiltration of CD10(+), 
      CD20(+), CD56(+) or CD138(+) cells was not revealed in all tumors. 
      Moderate-diffuse infiltration of CD163(+) cells was observed in all tumors. To 
      the best of our knowledge, the present study represents the first report of 
      intratumoral immune cells in alveolar soft part sarcoma. Frequent expression of 
      HLA class I in tumor cells was observed. CD8(+) cells were identified at various 
      densities and CD163(+) cells were observed in alveolar soft part sarcoma. 
      Moderate infiltration of CD8(+) cells in patients with a good prognosis may 
      indicate the antitumor effects of immune cells in alveolar soft part sarcoma.
FAU - Ogose, Akira
AU  - Ogose A
AD  - Department of Orthopedic Surgery, Uonuma Institute of Community Medicine, Niigata 
      University Medical and Dental Hospital, Minami-Uonuma, Niigata 949-7320, Japan.
AD  - Division of Orthopedic Surgery, Niigata University Graduate School of Medical and 
      Dental Sciences, Niigata 951-8510, Japan.
FAU - Kawashima, Hiroyuki
AU  - Kawashima H
AD  - Division of Orthopedic Surgery, Niigata University Graduate School of Medical and 
      Dental Sciences, Niigata 951-8510, Japan.
FAU - Hotta, Tetsuo
AU  - Hotta T
AD  - Division of Orthopedic Surgery, Niigata University Graduate School of Medical and 
      Dental Sciences, Niigata 951-8510, Japan.
FAU - Ariizumi, Takashi
AU  - Ariizumi T
AD  - Division of Orthopedic Surgery, Niigata University Graduate School of Medical and 
      Dental Sciences, Niigata 951-8510, Japan.
FAU - Yamagishi, Tetsuro
AU  - Yamagishi T
AD  - Division of Orthopedic Surgery, Niigata University Graduate School of Medical and 
      Dental Sciences, Niigata 951-8510, Japan.
FAU - Oike, Naoki
AU  - Oike N
AD  - Division of Orthopedic Surgery, Niigata University Graduate School of Medical and 
      Dental Sciences, Niigata 951-8510, Japan.
FAU - Sasaki, Taro
AU  - Sasaki T
AD  - Department of Orthopedic Surgery, Niigata Cancer Center Hospital, Niigata 
      951-8566, Japan.
FAU - Hatano, Hiroshi
AU  - Hatano H
AD  - Department of Orthopedic Surgery, Niigata Cancer Center Hospital, Niigata 
      951-8566, Japan.
FAU - Umezu, Hajime
AU  - Umezu H
AD  - Division of Pathology, Niigata University Medical and Dental Hospital, Niigata 
      951-8510, Japan.
FAU - Endo, Naoto
AU  - Endo N
AD  - Division of Orthopedic Surgery, Niigata University Graduate School of Medical and 
      Dental Sciences, Niigata 951-8510, Japan.
LA  - eng
PT  - Journal Article
DEP - 20170208
PL  - Greece
TA  - Oncol Lett
JT  - Oncology letters
JID - 101531236
PMC - PMC5403429
OTO - NOTNLM
OT  - alveolar soft part sarcoma
OT  - cluster of differentiation 163
OT  - cluster of differentiation 8
OT  - human leukocyte antigen class I
OT  - immune cells
EDAT- 2017/04/30 06:00
MHDA- 2017/04/30 06:01
PMCR- 2017/02/08
CRDT- 2017/04/30 06:00
PHST- 2015/11/12 00:00 [received]
PHST- 2016/12/16 00:00 [accepted]
PHST- 2017/04/30 06:00 [entrez]
PHST- 2017/04/30 06:00 [pubmed]
PHST- 2017/04/30 06:01 [medline]
PHST- 2017/02/08 00:00 [pmc-release]
AID - OL-0-0-5696 [pii]
AID - 10.3892/ol.2017.5696 [doi]
PST - ppublish
SO  - Oncol Lett. 2017 Apr;13(4):2169-2176. doi: 10.3892/ol.2017.5696. Epub 2017 Feb 8.