PMID- 28454494
OWN - NLM
STAT- MEDLINE
DCOM- 20171212
LR  - 20240530
IS  - 1521-0464 (Electronic)
IS  - 1071-7544 (Print)
IS  - 1071-7544 (Linking)
VI  - 24
IP  - 1
DP  - 2017 Nov
TI  - Preparation and testing of cefquinome-loaded poly lactic-co-glycolic acid 
      microspheres for lung targeting.
PG  - 745-751
LID - 10.1080/10717544.2017.1321058 [doi]
AB  - The aim of this study was to prepare cefquinome-loaded poly lactic-co-glycolic 
      acid (PLGA) microspheres and to evaluate their in vitro and in vivo 
      characteristics. Microspheres were prepared using a spry drier and were 
      characterized in terms of morphology, size, drug-loading coefficient, 
      encapsulation ratio and in vitro release. The prepared microspheres were 
      spherical with smooth surfaces and uniform size (12.4 +/- 1.2 mum). The 
      encapsulation efficiency and drug loading of cefquinome was 91.6 +/- 2.6 and 
      18.3 +/- 1.3%, respectively. In vitro release of cefquinome from the microspheres 
      was sustained for 36 h. In vivo studies identified the lung as the target tissue 
      and the region of maximum cefquinome release. A partial lung inflammation was 
      observed but disappeared spontaneously as the microspheres were removed through 
      in vivo decay. The sustained cefquinome release from the microspheres revealed 
      its applicability as a drug delivery system that minimized exposure to healthy 
      tissues while increasing the accumulation of therapeutic drug at the target site. 
      These results indicated that the spray-drying method of loading cefquinome into 
      PLGA microspheres is a straightforward method for lung targeting in animals.
FAU - Qu, Shaoqi
AU  - Qu S
AD  - a Agricultural Bio-Pharmaceutical Laboratory, Qingdao Agricultural University , 
      Qingdao , China and.
AD  - b National-Local Joint Engineering Laboratory of Agricultural Bio-Pharmaceutical 
      Technology , Qingdao , China.
FAU - Zhao, Li
AU  - Zhao L
AD  - a Agricultural Bio-Pharmaceutical Laboratory, Qingdao Agricultural University , 
      Qingdao , China and.
AD  - b National-Local Joint Engineering Laboratory of Agricultural Bio-Pharmaceutical 
      Technology , Qingdao , China.
FAU - Zhu, Jiajia
AU  - Zhu J
AD  - a Agricultural Bio-Pharmaceutical Laboratory, Qingdao Agricultural University , 
      Qingdao , China and.
AD  - b National-Local Joint Engineering Laboratory of Agricultural Bio-Pharmaceutical 
      Technology , Qingdao , China.
FAU - Wang, Chunmei
AU  - Wang C
AD  - a Agricultural Bio-Pharmaceutical Laboratory, Qingdao Agricultural University , 
      Qingdao , China and.
AD  - b National-Local Joint Engineering Laboratory of Agricultural Bio-Pharmaceutical 
      Technology , Qingdao , China.
FAU - Dai, Cunchun
AU  - Dai C
AD  - a Agricultural Bio-Pharmaceutical Laboratory, Qingdao Agricultural University , 
      Qingdao , China and.
AD  - b National-Local Joint Engineering Laboratory of Agricultural Bio-Pharmaceutical 
      Technology , Qingdao , China.
FAU - Guo, Hui
AU  - Guo H
AD  - a Agricultural Bio-Pharmaceutical Laboratory, Qingdao Agricultural University , 
      Qingdao , China and.
AD  - b National-Local Joint Engineering Laboratory of Agricultural Bio-Pharmaceutical 
      Technology , Qingdao , China.
FAU - Hao, Zhihui
AU  - Hao Z
AD  - a Agricultural Bio-Pharmaceutical Laboratory, Qingdao Agricultural University , 
      Qingdao , China and.
AD  - b National-Local Joint Engineering Laboratory of Agricultural Bio-Pharmaceutical 
      Technology , Qingdao , China.
LA  - eng
PT  - Journal Article
PL  - England
TA  - Drug Deliv
JT  - Drug delivery
JID - 9417471
RN  - 0 (Cephalosporins)
RN  - 0 (Glycols)
RN  - 1SIA8062RS (Polylactic Acid-Polyglycolic Acid Copolymer)
RN  - 26009-03-0 (Polyglycolic Acid)
RN  - 33X04XA5AT (Lactic Acid)
RN  - Z74S078CWP (cefquinome)
SB  - IM
MH  - Animals
MH  - Cephalosporins
MH  - Glycols
MH  - Lactic Acid
MH  - Lung
MH  - *Microspheres
MH  - Particle Size
MH  - Polyglycolic Acid
MH  - Polylactic Acid-Polyglycolic Acid Copolymer
PMC - PMC8241178
OTO - NOTNLM
OT  - Cefquinome
OT  - in vivo
OT  - poly lactic-co-glycolic acid microspheres
OT  - sustained release
OT  - target
COIS- The authors report no conflicts of interest. The authors alone are responsible 
      for the content and writing of this article. National Natural Science Foundation 
      of China10.13039/50110000180931402256201303038-8 High-Level Talent Research 
      Foundation of Qingdao Agricultural University631206.
EDAT- 2017/04/30 06:00
MHDA- 2017/12/13 06:00
PMCR- 2017/04/28
CRDT- 2017/04/30 06:00
PHST- 2017/04/30 06:00 [entrez]
PHST- 2017/04/30 06:00 [pubmed]
PHST- 2017/12/13 06:00 [medline]
PHST- 2017/04/28 00:00 [pmc-release]
AID - 1321058 [pii]
AID - 10.1080/10717544.2017.1321058 [doi]
PST - ppublish
SO  - Drug Deliv. 2017 Nov;24(1):745-751. doi: 10.1080/10717544.2017.1321058.