PMID- 28454718
OWN - NLM
STAT- MEDLINE
DCOM- 20170629
LR  - 20220321
IS  - 1879-0631 (Electronic)
IS  - 0024-3205 (Linking)
VI  - 179
DP  - 2017 Jun 15
TI  - Effects of co-administration of ketamine and ethanol on the dopamine system via 
      the cortex-striatum circuitry.
PG  - 1-8
LID - S0024-3205(17)30198-4 [pii]
LID - 10.1016/j.lfs.2017.04.018 [doi]
AB  - AIM: Ketamine and ethanol are increasingly being used together as recreational 
      drugs in rave parties. Their effects on the dopamine (DA) system remain largely 
      unknown. This study aimed to investigate the effects of consuming two different 
      concentrations of ketamine with and without alcohol on the DA system. MATERIALS 
      AND METHODS: We employed the conditioned place preference (CPP) paradigm to 
      evaluate the rewarding effects of the combined administration of two different 
      doses of ketamine (30mg/kg and 60mg/kg) with ethanol (0.3156g/kg). We evaluated 
      the effects of the combined drug treatment on the transcriptional output of 
      tyrosine hydroxylase (TH), dopa decarboxylase (DDC), synaptosomal-associated 
      protein 25 (SNAP25), and vesicular monoamine transporter 2 (VMAT2) as well as 
      protein expression level of brain-derived neurotrophic factor (BDNF) in rat 
      prefrontal cortex (PFC) and striatum. KEY FINDINGS: We found that rats exhibited 
      a dose-dependent, drug-paired, place preference to ketamine and ethanol 
      associated with an elevated DA level in the striatum but not in the PFC. 
      Moreover, treatment involving low- or high-dose ketamine with or without ethanol 
      caused a differential regulatory response in the mRNA levels of the four DA 
      metabolism genes and the cellular protein abundance of BDNF via the 
      cortex-striatum circuitry. SIGNIFICANCE: This study investigated the molecular 
      mechanisms that occur following the combined administration of ketamine and 
      ethanol in the DA system, which could potentially lead to alterations in the 
      mental status and behavior of ketamine/ethanol users. Our findings may aid the 
      development of therapeutic strategies for substance abuse patients.
CI  - Copyright (c) 2017 Elsevier Inc. All rights reserved.
FAU - Liu, Qing
AU  - Liu Q
AD  - School of Forensic Medicine, Kunming Medical University, Kunming, Yunnan, China.
FAU - Xu, Tian-Yong
AU  - Xu TY
AD  - Experiment Center for Medical Science Research, Kunming Medical University, 
      Kunming, Yunnan, China.
FAU - Zhang, Zhi-Bi
AU  - Zhang ZB
AD  - Experiment Center for Medical Science Research, Kunming Medical University, 
      Kunming, Yunnan, China.
FAU - Leung, Chi-Kwan
AU  - Leung CK
AD  - School of Biomedical Sciences, The Chinese University of Hong Kong, Hong Kong, 
      China; CUHK-SDU Joint Laboratory of Reproductive Genetics, School of Biomedical 
      Sciences, The Chinese University of Hong Kong, Hong Kong, China.
FAU - You, Ding-Yun
AU  - You DY
AD  - Department of Science and Technology, Kunming Medical University, Kunming, 
      Yunnan, China.
FAU - Wang, Shang-Wen
AU  - Wang SW
AD  - School of Forensic Medicine, Kunming Medical University, Kunming, Yunnan, China.
FAU - Yi, Shuai
AU  - Yi S
AD  - School of Forensic Medicine, Kunming Medical University, Kunming, Yunnan, China.
FAU - Jing, Qiang
AU  - Jing Q
AD  - School of Forensic Medicine, Kunming Medical University, Kunming, Yunnan, China.
FAU - Xie, Run-Fang
AU  - Xie RF
AD  - School of Forensic Medicine, Kunming Medical University, Kunming, Yunnan, China.
FAU - Li, Huifang-Jie
AU  - Li HJ
AD  - School of Forensic Medicine, Kunming Medical University, Kunming, Yunnan, China. 
      Electronic address: lhfj_8156@foxmail.com.
FAU - Zeng, Xiao-Feng
AU  - Zeng XF
AD  - School of Forensic Medicine, Kunming Medical University, Kunming, Yunnan, China. 
      Electronic address: zxf2004033@163.com.
LA  - eng
PT  - Journal Article
DEP - 20170426
PL  - Netherlands
TA  - Life Sci
JT  - Life sciences
JID - 0375521
RN  - 0 (Brain-Derived Neurotrophic Factor)
RN  - 0 (RNA, Messenger)
RN  - 3K9958V90M (Ethanol)
RN  - 690G0D6V8H (Ketamine)
RN  - VTD58H1Z2X (Dopamine)
SB  - IM
EIN - Life Sci. 2017 Jul 15;181:70. PMID: 28587724
MH  - Animals
MH  - Behavior, Animal/drug effects
MH  - Brain-Derived Neurotrophic Factor/metabolism
MH  - Conditioning, Psychological/drug effects
MH  - Corpus Striatum/*drug effects/metabolism
MH  - Dopamine/*metabolism
MH  - Dose-Response Relationship, Drug
MH  - Ethanol/administration & dosage/*pharmacology
MH  - Ketamine/administration & dosage/*pharmacology
MH  - Male
MH  - Prefrontal Cortex/*drug effects/metabolism
MH  - RNA, Messenger/metabolism
MH  - Rats
MH  - Rats, Sprague-Dawley
OTO - NOTNLM
OT  - Conditioned place preference
OT  - Dopamine
OT  - Ethanol
OT  - Ketamine
OT  - SNAP25
EDAT- 2017/04/30 06:00
MHDA- 2017/07/01 06:00
CRDT- 2017/04/30 06:00
PHST- 2017/03/02 00:00 [received]
PHST- 2017/04/21 00:00 [revised]
PHST- 2017/04/24 00:00 [accepted]
PHST- 2017/04/30 06:00 [pubmed]
PHST- 2017/07/01 06:00 [medline]
PHST- 2017/04/30 06:00 [entrez]
AID - S0024-3205(17)30198-4 [pii]
AID - 10.1016/j.lfs.2017.04.018 [doi]
PST - ppublish
SO  - Life Sci. 2017 Jun 15;179:1-8. doi: 10.1016/j.lfs.2017.04.018. Epub 2017 Apr 26.