PMID- 28455366
OWN - NLM
STAT- MEDLINE
DCOM- 20170824
LR  - 20240313
IS  - 1473-0480 (Electronic)
IS  - 0306-3674 (Linking)
VI  - 51
IP  - 14
DP  - 2017 Jul
TI  - Effect of cardiorespiratory and strength exercises on disease activity in 
      patients with inflammatory rheumatic diseases: a systematic review and 
      meta-analysis.
PG  - 1065-1072
LID - 10.1136/bjsports-2016-097149 [doi]
AB  - OBJECTIVE: To investigate the effects of cardiorespiratory and strength exercises 
      on disease activity for patients with inflammatory rheumatic diseases (IRDs). 
      DESIGN: A systematic review with meta-analysis registered at PROSPERO 
      (CRD42015020004). PARTICIPANTS: Patients with IRDs. DATA SOURCES: The databases 
      MEDLINE, AMED, Embase and CINAHL were searched from inception up to April 2016. 
      ELIGIBILITY CRITERIA FOR SELECTING STUDIES: Trials were included if they were 
      randomised controlled trials of adults with IRDs, comparing the effect of 
      cardiorespiratory and strength exercises with usual care on disease activity and 
      followed the American College of Sports Medicine's exercise recommendations. The 
      primary outcome was disease activity in terms of inflammation, joint damage and 
      symptoms. DATA SYNTHESIS: Data were pooled in a random-effect model for all 
      outcomes, and standardised mean differences (SMDs) were calculated. The quality 
      of evidence was evaluated according to the Grading of Recommendations Assessment, 
      Development and Evaluation approach. RESULTS: Twenty-six trials with a total of 
      1286 participants were included. There was high to moderate quality evidence, for 
      a small beneficial effect on disease activity scores (0.19 (95% CI 0.05 to 0.33), 
      p<0.01) and joint damage (SMD 0.27 (95% CI 0.07 to 0.46), p<0.01). Furthermore, 
      moderate quality evidence for a small beneficial effect on erythrocyte 
      sedimentation rate (SMD 0.20 (95% CI 0.0 to 0.39), p=0.04) and for no effect on C 
      reactive protein (SMD -0.14 (95% CI -0.37 to 0.08), p=0.21). Beneficial effects 
      were also seen for symptoms. CONCLUSIONS: The results of this review suggest 
      beneficial effects of exercises on inflammation, joint damage and symptoms in 
      patients with IRDs.
CI  - (c) Article author(s) (or their employer(s) unless otherwise stated in the text of 
      the article) 2017. All rights reserved. No commercial use is permitted unless 
      otherwise expressly granted.
FAU - Sveaas, Silje Halvorsen
AU  - Sveaas SH
AD  - Department of Rheumatology, National Advisory Unit on Rehabilitation in 
      Rheumatology, Diakonhjemmet Sykehus, Oslo, Norway.
AD  - Department of Health Sciences, Institute of Health and Society, University of 
      Oslo, Oslo, Norway.
FAU - Smedslund, Geir
AU  - Smedslund G
AD  - Department of Rheumatology, National Advisory Unit on Rehabilitation in 
      Rheumatology, Diakonhjemmet Sykehus, Oslo, Norway.
AD  - The Norwegian Knowledge Center for the Health Services, The Norwegian Institute 
      of Public Health, Oslo, Norway.
FAU - Hagen, Kare Birger
AU  - Hagen KB
AD  - Department of Rheumatology, National Advisory Unit on Rehabilitation in 
      Rheumatology, Diakonhjemmet Sykehus, Oslo, Norway.
AD  - Department of Health Sciences, Institute of Health and Society, University of 
      Oslo, Oslo, Norway.
FAU - Dagfinrud, Hanne
AU  - Dagfinrud H
AD  - Department of Rheumatology, National Advisory Unit on Rehabilitation in 
      Rheumatology, Diakonhjemmet Sykehus, Oslo, Norway.
AD  - Department of Health Sciences, Institute of Health and Society, University of 
      Oslo, Oslo, Norway.
LA  - eng
PT  - Journal Article
PT  - Meta-Analysis
PT  - Review
PT  - Systematic Review
DEP - 20170428
PL  - England
TA  - Br J Sports Med
JT  - British journal of sports medicine
JID - 0432520
SB  - IM
CIN - Front Immunol. 2023 Jan 06;13:1089621. PMID: 36685485
MH  - *Exercise Therapy
MH  - Humans
MH  - Inflammation/therapy
MH  - Randomized Controlled Trials as Topic
MH  - Rheumatic Diseases/*therapy
OTO - NOTNLM
OT  - Exercises
COIS- Competing interests: None declared.
EDAT- 2017/04/30 06:00
MHDA- 2017/08/25 06:00
CRDT- 2017/04/30 06:00
PHST- 2017/03/12 00:00 [accepted]
PHST- 2017/04/30 06:00 [pubmed]
PHST- 2017/08/25 06:00 [medline]
PHST- 2017/04/30 06:00 [entrez]
AID - bjsports-2016-097149 [pii]
AID - 10.1136/bjsports-2016-097149 [doi]
PST - ppublish
SO  - Br J Sports Med. 2017 Jul;51(14):1065-1072. doi: 10.1136/bjsports-2016-097149. 
      Epub 2017 Apr 28.