PMID- 28455814
OWN - NLM
STAT- MEDLINE
DCOM- 20180326
LR  - 20181113
IS  - 1439-6327 (Electronic)
IS  - 1439-6319 (Linking)
VI  - 117
IP  - 7
DP  - 2017 Jul
TI  - Adaptations in corticospinal excitability and inhibition are not spatially 
      confined to the agonist muscle following strength training.
PG  - 1359-1371
LID - 10.1007/s00421-017-3624-y [doi]
AB  - PURPOSE: We used transcranial magnetic stimulation (TMS) to determine the 
      corticospinal responses from an agonist and synergist muscle following strength 
      training of the right elbow flexors. METHODS: Motor-evoked potentials were 
      recorded from the biceps brachii and flexor carpi radialis during a submaximal 
      contraction from 20 individuals (10 women, 10 men, aged 18-35 years; training 
      group; n = 10 and control group; n = 10) before and after 3 weeks of strength 
      training at 80% of 1-repetition maximum (1-RM). To characterise the input-output 
      properties of the corticospinal tract, stimulus-response curves for corticospinal 
      excitability and inhibition of the right biceps brachii and flexor carpi radialis 
      were constructed and assessed by examining the area under the recruitment curve 
      (AURC). RESULTS: Strength training resulted in a 29% (P < 0.001) increase in 1-RM 
      biceps brachii strength and this was accompanied by a 19% increase in isometric 
      strength of the wrist flexors (P = 0.001). TMS revealed an increase in 
      corticospinal excitability AURC and a decrease in silent period duration AURC for 
      the biceps brachii and flexor carpi radialis following strength training (all 
      P < 0.05). However, the changes in corticospinal function were not associated 
      with increased muscle strength. CONCLUSION: These findings show that the 
      corticospinal responses to strength training of a proximal upper limb muscle are 
      not spatially restricted, but rather, results in a change in connectivity, among 
      an agonist and a synergistic muscle relevant to force production.
FAU - Mason, Joel
AU  - Mason J
AD  - Discipline of Exercise Science, School of Allied Health, La Trobe University, 
      Melbourne, Australia.
FAU - Frazer, Ashlyn
AU  - Frazer A
AD  - Discipline of Exercise Science, School of Allied Health, La Trobe University, 
      Melbourne, Australia.
FAU - Horvath, Deanna M
AU  - Horvath DM
AD  - Department of Physiology, Anatomy and Microbiology, School of Life Sciences, La 
      Trobe University, Melbourne, Australia.
FAU - Pearce, Alan J
AU  - Pearce AJ
AD  - Discipline of Exercise Science, School of Allied Health, La Trobe University, 
      Melbourne, Australia.
FAU - Avela, Janne
AU  - Avela J
AD  - Department of Biology and Physical Activity, University of Jyvaskyla, Jyvaskyla, 
      Finland.
FAU - Howatson, Glyn
AU  - Howatson G
AD  - Department of Sport, Exercise and Rehabilitation, Northumbria University, 
      Newcastle, UK.
AD  - Water Research Group, School of Environmental Sciences and Development, Northwest 
      University, Potchefstroom, South Africa.
FAU - Kidgell, Dawson
AU  - Kidgell D
AD  - Discipline of Exercise Science, School of Allied Health, La Trobe University, 
      Melbourne, Australia. D.Kidgell@latrobe.edu.au.
LA  - eng
PT  - Journal Article
PT  - Randomized Controlled Trial
DEP - 20170428
PL  - Germany
TA  - Eur J Appl Physiol
JT  - European journal of applied physiology
JID - 100954790
SB  - IM
MH  - *Adaptation, Physiological
MH  - Adolescent
MH  - Adult
MH  - Elbow/physiology
MH  - *Evoked Potentials, Motor
MH  - *Exercise
MH  - Female
MH  - Humans
MH  - Male
MH  - Muscle, Skeletal/*innervation/physiology
MH  - *Neural Inhibition
MH  - Pyramidal Tracts/*physiology
OTO - NOTNLM
OT  - Agonist
OT  - Corticospinal excitability
OT  - Corticospinal inhibition
OT  - Strength training
OT  - Synergist
OT  - Voluntary strength
EDAT- 2017/04/30 06:00
MHDA- 2018/03/27 06:00
CRDT- 2017/04/30 06:00
PHST- 2016/12/19 00:00 [received]
PHST- 2017/04/25 00:00 [accepted]
PHST- 2017/04/30 06:00 [pubmed]
PHST- 2018/03/27 06:00 [medline]
PHST- 2017/04/30 06:00 [entrez]
AID - 10.1007/s00421-017-3624-y [pii]
AID - 10.1007/s00421-017-3624-y [doi]
PST - ppublish
SO  - Eur J Appl Physiol. 2017 Jul;117(7):1359-1371. doi: 10.1007/s00421-017-3624-y. 
      Epub 2017 Apr 28.