PMID- 28456776 OWN - NLM STAT- MEDLINE DCOM- 20180220 LR - 20180816 IS - 1899-1505 (Electronic) IS - 0867-5910 (Linking) VI - 68 IP - 1 DP - 2017 Feb TI - Effect of sprint cycling and stretch-shortening cycle exercises on the neuromuscular, immune and stress indicators in young men. PG - 125-132 AB - Selection of optimal physical load is essential for desired adaptation including health benefits. We hypothesized that neuromuscular, immune and stress indicators will be higher after energy demanding sprint interval exercise (SIE) than to mechanically demanding stretch-shortening cycle exercise (SSE). The main aim of this study was to assess and compare the kinetics of blood brain-derived neurotrophic factor (BDNF), norepinephrine (NE) and cortisol (as stress indicators) and proinflammatory (IL-6) and anti-inflammatory (IL-10) cytokines within 24 hours after metabolically demanding SIE and after muscle damage inducing SSE. Twenty healthy physically active young men randomly assigned to two equal groups to complete 12 bouts of 5 s stationary cycling sprints every 3 min (SIE) or 200 drop-jumps with 30 s interval between each jump (SSE), respectively. Quadriceps muscle maximal voluntary contraction torque and voluntary activation and soreness were measured and blood samples collected before and 2 min, 1 hour, 12 hours and 24 hours after the SIE and SSE. The BDNF, cortisol, IL-6 and NE levels increased more at 2 min after SIE than SSE (P < 0.05); however, the IL-10 level did not differ between SIE and SSE. BDNF and cortisol levels were decreased at 24 h after both SIE and especially after SSE. The higher was the initial BDNF level, the greater was its decrease at 24 h after both type of exercise. Before exercise BDNF level correlated closely with the change in central fatigue (decrease in voluntary activation) after both SIE and SSE. We thus conclude that both metabolically demanding SIE and muscle damage inflicting SSE induced long-lasting decrease in circulating BDNF which may not promote brain health. The level of circulating BDNF, but not cortisol, IL-6, IL-10 or NE, was associated with changes in central motor fatigue. FAU - Verbickas, V AU - Verbickas V AD - Institute of Sports Science and Innovation, Lithuanian Sports University, Kaunas, Lithuania. v.verbickas@gmail.com. FAU - Baranauskiene, N AU - Baranauskiene N AD - Institute of Sports Science and Innovation, Lithuanian Sports University, Kaunas, Lithuania. FAU - Eimantas, N AU - Eimantas N AD - Institute of Sports Science and Innovation, Lithuanian Sports University, Kaunas, Lithuania. FAU - Kamandulis, S AU - Kamandulis S AD - Institute of Sports Science and Innovation, Lithuanian Sports University, Kaunas, Lithuania. FAU - Rutkauskas, S AU - Rutkauskas S AD - Department of Radiology, Medical Academy, Lithuanian University of Health Sciences, Kaunas, Lithuania. FAU - Satkunskiene, D AU - Satkunskiene D AD - Institute of Sports Science and Innovation, Lithuanian Sports University, Kaunas, Lithuania. FAU - Sadauskas, S AU - Sadauskas S AD - Department of Internal Diseases, Lithuanian University of Health Sciences, Kaunas, Lithuania. FAU - Brazaitis, M AU - Brazaitis M AD - Institute of Sports Science and Innovation, Lithuanian Sports University, Kaunas, Lithuania. FAU - Skurvydas, A AU - Skurvydas A AD - Institute of Sports Science and Innovation, Lithuanian Sports University, Kaunas, Lithuania. LA - eng PT - Clinical Trial PT - Journal Article PL - Poland TA - J Physiol Pharmacol JT - Journal of physiology and pharmacology : an official journal of the Polish Physiological Society JID - 9114501 RN - 0 (Brain-Derived Neurotrophic Factor) RN - 0 (IL10 protein, human) RN - 0 (IL6 protein, human) RN - 0 (Interleukin-6) RN - 130068-27-8 (Interleukin-10) RN - 7171WSG8A2 (BDNF protein, human) RN - EC 2.7.3.2 (Creatine Kinase) RN - WI4X0X7BPJ (Hydrocortisone) RN - X4W3ENH1CV (Norepinephrine) SB - IM MH - Adult MH - Bicycling/*physiology MH - Brain-Derived Neurotrophic Factor/blood MH - Creatine Kinase/blood MH - Exercise/*physiology MH - Humans MH - Hydrocortisone/blood MH - Interleukin-10/blood MH - Interleukin-6/blood MH - Male MH - Muscle Contraction MH - Muscle Fatigue/immunology/physiology MH - Norepinephrine/blood MH - Quadriceps Muscle/physiology MH - Young Adult EDAT- 2017/05/01 06:00 MHDA- 2018/02/21 06:00 CRDT- 2017/05/01 06:00 PHST- 2016/10/19 00:00 [received] PHST- 2017/01/11 00:00 [accepted] PHST- 2017/05/01 06:00 [entrez] PHST- 2017/05/01 06:00 [pubmed] PHST- 2018/02/21 06:00 [medline] PST - ppublish SO - J Physiol Pharmacol. 2017 Feb;68(1):125-132.