PMID- 28456929
OWN - NLM
STAT- MEDLINE
DCOM- 20190429
LR  - 20190429
IS  - 0065-2598 (Print)
IS  - 0065-2598 (Linking)
VI  - 1021
DP  - 2017
TI  - Carotid Intima-Media Thickness and Metabolic Syndrome Components in Obese 
      Children and Adolescents.
PG  - 63-72
LID - 10.1007/5584_2017_29 [doi]
AB  - Obesity in children and adolescents contributes to increased prevalence of 
      metabolic and hemodynamic complications, which may impair endothelial function 
      and structure. A high resolution B-mode ultrasound measurement of intima-media 
      thickness (IMT) is a useful tool to assess early, preclinical stage of 
      atherosclerosis. The objective of this study was to evaluate the carotid artery 
      IMT in obese children and its association with insulin resistance and other 
      traditional metabolic syndrome components. The study entailed 80 obese children, 
      aged 5.3-17.9 year and a control group of 31 children. Obesity was defined using 
      the International Obesity Task Force (IOTF) criteria. Metabolic syndrome was 
      defined using the International Diabetes Federation (IDF) criteria of 2007. Each 
      patient's anthropometric measurements, blood parameters, and the carotid IMT were 
      evaluated. Insulin resistance indices were calculated. We found that children 
      with metabolic syndrome had a significantly increased IMT compared to children 
      who did not meet the syndrome criteria (0.62 +/- 0.09 mm vs. 0.55 +/- 0.18 mm, 
      p = 0.03) and compared to control group (0.62 +/- 0.09 vs. 0.52 +/- 0.14, p = 0.02). 
      In a multivariable linear regression analysis, IMT correlated with systolic blood 
      pressure (p = 0.005). The results did not show an association between IMT and 
      insulin resistance. We conclude that abdominal obesity and the accompanying 
      components of metabolic syndrome lead to increased carotid IMT. The enhanced 
      systolic blood pressure plays a major role in changing the carotid IMT.
FAU - Ruminska, Malgorzata
AU  - Ruminska M
AD  - Department of Pediatrics and Endocrinology, Warsaw Medical University, Waraw, 
      Poland. mruminska@wum.edu.pl.
FAU - Witkowska-Sedek, Ewelina
AU  - Witkowska-Sedek E
AD  - Department of Pediatrics and Endocrinology, Warsaw Medical University, Waraw, 
      Poland.
FAU - Majcher, Anna
AU  - Majcher A
AD  - Department of Pediatrics and Endocrinology, Warsaw Medical University, Waraw, 
      Poland.
FAU - Brzewski, Michal
AU  - Brzewski M
AD  - Department of Pediatric Radiology, Warsaw Medical University, Waraw, Poland.
FAU - Czerwonogrodzka-Senczyna, Aneta
AU  - Czerwonogrodzka-Senczyna A
AD  - Department of Human Nutrition, Warsaw Medical University, Waraw, Poland.
FAU - Demkow, Urszula
AU  - Demkow U
AD  - Department of Laboratory Diagnostics and Clinical Immunology, Warsaw Medical 
      University, Waraw, Poland.
FAU - Pyrzak, Beata
AU  - Pyrzak B
AD  - Department of Pediatrics and Endocrinology, Warsaw Medical University, Waraw, 
      Poland.
LA  - eng
PT  - Journal Article
PL  - United States
TA  - Adv Exp Med Biol
JT  - Advances in experimental medicine and biology
JID - 0121103
SB  - IM
MH  - Adolescent
MH  - *Blood Pressure
MH  - Carotid Arteries/pathology
MH  - *Carotid Intima-Media Thickness
MH  - Child
MH  - Child, Preschool
MH  - Humans
MH  - Insulin Resistance
MH  - Metabolic Syndrome/*complications
MH  - Pediatric Obesity/*complications
MH  - Risk Factors
OTO - NOTNLM
OT  - Blood pressure
OT  - Carotid artery
OT  - Intima-media thickness
OT  - Metabolic syndrome
OT  - Obesity
EDAT- 2017/05/01 06:00
MHDA- 2019/04/30 06:00
CRDT- 2017/05/01 06:00
PHST- 2017/05/01 06:00 [pubmed]
PHST- 2019/04/30 06:00 [medline]
PHST- 2017/05/01 06:00 [entrez]
AID - 10.1007/5584_2017_29 [doi]
PST - ppublish
SO  - Adv Exp Med Biol. 2017;1021:63-72. doi: 10.1007/5584_2017_29.