PMID- 28456938
OWN - NLM
STAT- MEDLINE
DCOM- 20190226
LR  - 20190226
IS  - 1559-1182 (Electronic)
IS  - 0893-7648 (Linking)
VI  - 55
IP  - 4
DP  - 2018 Apr
TI  - Glioprotective Effect of Resveratrol: an Emerging Therapeutic Role for 
      Oligodendroglial Cells.
PG  - 2967-2978
LID - 10.1007/s12035-017-0510-x [doi]
AB  - Resveratrol is a natural polyphenol compound highly found in red wine that 
      displays several beneficial effects on the central nervous system (CNS), 
      preventing or slowing the progression of a wide variety of neurological diseases. 
      Its neuroprotective role is particularly associated to modulation of antioxidant 
      and anti-inflammatory responses in glial cells in a mechanism dependent of heme 
      oxygenase 1 (HO-1) signaling pathway. Oligodendrocyte progenitor cells (OPC), 
      primarily known for giving rise to mature oligodendrocytes, have emerged as 
      dynamic cells that are also important to maintain the CNS homeostasis. In this 
      sense, we have demonstrated that resveratrol has a protective effect on 
      oligodendroglial functionality against lipopolysaccharide (LPS)-mediated 
      cytotoxicity and that its glioprotective mechanism involves the nuclear factor 
      erythroid 2-related factor 2 (Nrf2) and HO-1 pathways. LPS, through toll-like 
      receptor 4 (TLR4), affected the release of trophic factors by OPC, including 
      transforming growth factor beta (TGF-beta), brain-derived neurotrophic factor 
      (BDNF), and glial cell-derived neurotrophic factor (GDNF), and resveratrol 
      reestablished the trophic factor release to control levels. Additionally, 
      resveratrol prevented the LPS-induced increase in the intracellular reactive 
      oxygen species (ROS) as well as the decrease in glutathione (GSH) levels and in 
      glutamate cysteine ligase (GCL) activity, through Nrf2/HO-1 signaling pathways. 
      Resveratrol also prevented the increase of the transcriptional activities of 
      nuclear factor kappaB (NFkappaB) and hypoxia-inducible factor 1 alpha (HIF-1alpha) after LPS 
      challenge. In summary, this is the first study showing the glioprotective effect 
      of resveratrol on oligodendroglial cells.
FAU - Rosa, Priscila Machado
AU  - Rosa PM
AD  - Departamento de Bioquimica, Programa de Pos-Graduacao em Ciencias Biologicas: 
      Bioquimica, Instituto de Ciencias Basicas da Saude, Universidade Federal do Rio 
      Grande do Sul, Rua Ramiro Barcelos, 2600-Anexo, Bairro Santa Cecilia, Porto 
      Alegre, RS, 90035-003, Brazil.
FAU - Martins, Leo Anderson Meira
AU  - Martins LAM
AD  - Departamento de Bioquimica, Programa de Pos-Graduacao em Ciencias Biologicas: 
      Bioquimica, Instituto de Ciencias Basicas da Saude, Universidade Federal do Rio 
      Grande do Sul, Rua Ramiro Barcelos, 2600-Anexo, Bairro Santa Cecilia, Porto 
      Alegre, RS, 90035-003, Brazil.
FAU - Souza, Diogo Onofre
AU  - Souza DO
AD  - Departamento de Bioquimica, Programa de Pos-Graduacao em Ciencias Biologicas: 
      Bioquimica, Instituto de Ciencias Basicas da Saude, Universidade Federal do Rio 
      Grande do Sul, Rua Ramiro Barcelos, 2600-Anexo, Bairro Santa Cecilia, Porto 
      Alegre, RS, 90035-003, Brazil.
FAU - Quincozes-Santos, Andre
AU  - Quincozes-Santos A
AD  - Departamento de Bioquimica, Programa de Pos-Graduacao em Ciencias Biologicas: 
      Bioquimica, Instituto de Ciencias Basicas da Saude, Universidade Federal do Rio 
      Grande do Sul, Rua Ramiro Barcelos, 2600-Anexo, Bairro Santa Cecilia, Porto 
      Alegre, RS, 90035-003, Brazil. andrequincozes@ufrgs.br.
LA  - eng
PT  - Journal Article
DEP - 20170429
PL  - United States
TA  - Mol Neurobiol
JT  - Molecular neurobiology
JID - 8900963
RN  - 0 (Biomarkers)
RN  - 0 (Brain-Derived Neurotrophic Factor)
RN  - 0 (Glial Cell Line-Derived Neurotrophic Factor)
RN  - 0 (Lipopolysaccharides)
RN  - 0 (NF-E2-Related Factor 2)
RN  - 0 (Neuroprotective Agents)
RN  - 0 (RNA, Messenger)
RN  - 0 (Reactive Oxygen Species)
RN  - 0 (Transcription Factor RelA)
RN  - 0 (Transforming Growth Factor beta)
RN  - EC 1.14.14.18 (Heme Oxygenase-1)
RN  - GAN16C9B8O (Glutathione)
RN  - Q369O8926L (Resveratrol)
SB  - IM
MH  - Animals
MH  - Animals, Newborn
MH  - Biomarkers/metabolism
MH  - Brain-Derived Neurotrophic Factor/metabolism
MH  - Cell Death/drug effects
MH  - Cells, Cultured
MH  - Glial Cell Line-Derived Neurotrophic Factor/metabolism
MH  - Glutathione/metabolism
MH  - Heme Oxygenase-1/genetics/metabolism
MH  - Inflammation/pathology
MH  - Lipopolysaccharides
MH  - Models, Biological
MH  - NF-E2-Related Factor 2/genetics/metabolism
MH  - Neuroprotective Agents/*pharmacology
MH  - Oligodendroglia/*cytology/drug effects
MH  - RNA, Messenger/genetics/metabolism
MH  - Rats, Wistar
MH  - Reactive Oxygen Species/metabolism
MH  - Resveratrol/*pharmacology
MH  - Signal Transduction
MH  - Transcription Factor RelA/metabolism
MH  - Transforming Growth Factor beta/metabolism
OTO - NOTNLM
OT  - Heme oxygenase-1
OT  - LPS
OT  - Oligodendrocyte progenitor cells
OT  - Resveratrol
EDAT- 2017/05/01 06:00
MHDA- 2019/02/27 06:00
CRDT- 2017/05/01 06:00
PHST- 2016/10/24 00:00 [received]
PHST- 2017/04/04 00:00 [accepted]
PHST- 2017/05/01 06:00 [pubmed]
PHST- 2019/02/27 06:00 [medline]
PHST- 2017/05/01 06:00 [entrez]
AID - 10.1007/s12035-017-0510-x [pii]
AID - 10.1007/s12035-017-0510-x [doi]
PST - ppublish
SO  - Mol Neurobiol. 2018 Apr;55(4):2967-2978. doi: 10.1007/s12035-017-0510-x. Epub 
      2017 Apr 29.