PMID- 28457412
OWN - NLM
STAT- MEDLINE
DCOM- 20180102
LR  - 20191210
IS  - 1873-2623 (Electronic)
IS  - 0041-1345 (Linking)
VI  - 49
IP  - 4
DP  - 2017 May
TI  - Factors Related to Hepatocellular Carcinoma Recurrence After Liver 
      Transplantation-A Brazilian Multicenter Study.
PG  - 863-866
LID - S0041-1345(17)30069-6 [pii]
LID - 10.1016/j.transproceed.2017.01.055 [doi]
AB  - BACKGROUND: Liver transplantation (LT) is a curative treatment option for 
      hepatocellular carcinoma (HCC); recurrent HCC after liver transplantation (HCC-R) 
      is diagnosed in 9%-16%. The objective of this study was to evaluate which factors 
      are associated with R-HCC after liver transplantation. METHODS: This 
      retrospective real-life study analyzed 278 LTs from 3 reference centers (2,093 
      LTs) in Brazil from 1988 to 2015. HCC-R with histologic confirmation was seen in 
      40 patients (14.4%). RESULTS: Most of them were male with cirrhosis secondary to 
      viral hepatitis. Only 37.5% underwent chemoembolization, and 50% had cold 
      ischemia time >8 hours. From the explant analysis, most of the patients were 
      outside Milan criteria and 37.5% had microvascular invasion. The donors were 
      mostly male, and the median intensive care unit time was >3 days. The 
      Kaplan-Meier survival was lower according to alpha-fetoprotein (AFP) >200 ng/dL 
      (P = .02), and older donors and more blood transfusions were risk factors for 
      HCC-R death. CONCLUSION: AFP >200 ng/mL was associated with lower survival, and 
      older donors and more blood transfusions were risk factors for death after HCC-R. 
      A trend to lower survival was observed in patients who did not have 
      chemoembolization and had cold ischemia times >8 hours.
CI  - Copyright (c) 2017 Elsevier Inc. All rights reserved.
FAU - Bina Possatto, M
AU  - Bina Possatto M
AD  - Unit of Liver Transplantation, Clinical Hospital, State University of Campinas, 
      Campinas, Brazil.
FAU - de Ataide, E C
AU  - de Ataide EC
AD  - Unit of Liver Transplantation, Clinical Hospital, State University of Campinas, 
      Campinas, Brazil.
FAU - Fazzio Escanhoela, C A
AU  - Fazzio Escanhoela CA
AD  - Unit of Liver Transplantation, Clinical Hospital, State University of Campinas, 
      Campinas, Brazil.
FAU - Seva-Pereira, T
AU  - Seva-Pereira T
AD  - Unit of Liver Transplantation, Clinical Hospital, State University of Campinas, 
      Campinas, Brazil.
FAU - de Cassia Martins Alves da Silva, R
AU  - de Cassia Martins Alves da Silva R
AD  - Liver Transplantation, Faculty of Medicine Sao Jose do Rio Preto, Rio Preto, 
      Brazil.
FAU - Felicio, H
AU  - Felicio H
AD  - Liver Transplantation, Faculty of Medicine Sao Jose do Rio Preto, Rio Preto, 
      Brazil.
FAU - de Navarro Amado, L R
AU  - de Navarro Amado LR
AD  - Liver Transplantation, Minas Gerais Federal University, Belo Horizonte, Brazil.
FAU - Ferreira da Silva, R
AU  - Ferreira da Silva R
AD  - Liver Transplantation, Faculty of Medicine Sao Jose do Rio Preto, Rio Preto, 
      Brazil.
FAU - Soares Lima, A
AU  - Soares Lima A
AD  - Liver Transplantation, Minas Gerais Federal University, Belo Horizonte, Brazil.
FAU - Boin, I F S F
AU  - Boin IFSF
AD  - Unit of Liver Transplantation, Clinical Hospital, State University of Campinas, 
      Campinas, Brazil. Electronic address: ilkaboin@yahoo.com.
LA  - eng
PT  - Evaluation Study
PT  - Journal Article
PT  - Multicenter Study
PL  - United States
TA  - Transplant Proc
JT  - Transplantation proceedings
JID - 0243532
RN  - 0 (alpha-Fetoproteins)
SB  - IM
MH  - Adult
MH  - Aged
MH  - Blood Transfusion/statistics & numerical data
MH  - Brazil
MH  - Carcinoma, Hepatocellular/*pathology/surgery
MH  - Cold Ischemia/*adverse effects
MH  - Embolization, Therapeutic
MH  - Female
MH  - Humans
MH  - Kaplan-Meier Estimate
MH  - Liver Cirrhosis/surgery/virology
MH  - Liver Neoplasms/*pathology/surgery
MH  - Liver Transplantation/*adverse effects
MH  - Male
MH  - Middle Aged
MH  - Neoplasm Recurrence, Local/*etiology
MH  - Retrospective Studies
MH  - Risk Factors
MH  - Tissue Donors
MH  - alpha-Fetoproteins/analysis
EDAT- 2017/05/02 06:00
MHDA- 2018/01/03 06:00
CRDT- 2017/05/02 06:00
PHST- 2017/05/02 06:00 [entrez]
PHST- 2017/05/02 06:00 [pubmed]
PHST- 2018/01/03 06:00 [medline]
AID - S0041-1345(17)30069-6 [pii]
AID - 10.1016/j.transproceed.2017.01.055 [doi]
PST - ppublish
SO  - Transplant Proc. 2017 May;49(4):863-866. doi: 10.1016/j.transproceed.2017.01.055.