PMID- 28458256
OWN - NLM
STAT- MEDLINE
DCOM- 20180322
LR  - 20181113
IS  - 1945-4589 (Electronic)
IS  - 1945-4589 (Linking)
VI  - 9
IP  - 5
DP  - 2017 Apr 29
TI  - Aging-associated oxidative stress inhibits liver progenitor cell activation in 
      mice.
PG  - 1359-1374
LID - 10.18632/aging.101232 [doi]
AB  - Recent studies have discovered aging-associated changes of adult stem cells in 
      various tissues and organs, which potentially contribute to the organismal aging. 
      However, aging-associated changes of liver progenitor cells (LPCs) remain 
      elusive. Employing young (2-month-old) and old (24-month-old) mice, we found 
      diverse novel alterations in LPC activation during aging. LPCs in young mice 
      could be activated and proliferate upon liver injury, whereas the counterparts in 
      old mice failed to respond and proliferate, leading to the impaired liver 
      regeneration. Surprisingly, isolated LPCs from young and old mice did not exhibit 
      significant difference in their clonogenic and proliferative capacity. Later, we 
      uncovered that the decreased activation and proliferation of LPCs were due to 
      excessive reactive oxygen species produced by neutrophils infiltrated into niche, 
      which was resulted from chemokine production from activated hepatic stellate 
      cells during aging. This study demonstrates aging-associated changes in LPC 
      activation and reveals critical roles for the stem cell niche, including 
      neutrophils and hepatic stellate cells, in the negative regulation of LPCs during 
      aging.
FAU - Cheng, Yiji
AU  - Cheng Y
AD  - Shanghai Institute of Immunology and Shanghai Chest Hospital, Shanghai Jiao Tong 
      University School of Medicine, Shanghai, China.
FAU - Wang, Xue
AU  - Wang X
AD  - Shanghai Institute of Immunology and Shanghai Chest Hospital, Shanghai Jiao Tong 
      University School of Medicine, Shanghai, China.
FAU - Wang, Bei
AU  - Wang B
AD  - Key Laboratory of Stem Cell Biology, Institute of Health Sciences, Shanghai 
      Institutes for Biological Sciences, Chinese Academy of Sciences and Shanghai Jiao 
      Tong University School of Medicine, Shanghai, China.
FAU - Zhou, Hong
AU  - Zhou H
AD  - Key Laboratory of Stem Cell Biology, Institute of Health Sciences, Shanghai 
      Institutes for Biological Sciences, Chinese Academy of Sciences and Shanghai Jiao 
      Tong University School of Medicine, Shanghai, China.
FAU - Dang, Shipeng
AU  - Dang S
AD  - Key Laboratory of Stem Cell Biology, Institute of Health Sciences, Shanghai 
      Institutes for Biological Sciences, Chinese Academy of Sciences and Shanghai Jiao 
      Tong University School of Medicine, Shanghai, China.
FAU - Shi, Yufang
AU  - Shi Y
AD  - Key Laboratory of Stem Cell Biology, Institute of Health Sciences, Shanghai 
      Institutes for Biological Sciences, Chinese Academy of Sciences and Shanghai Jiao 
      Tong University School of Medicine, Shanghai, China.
FAU - Hao, Li
AU  - Hao L
AD  - Clinical Laboratory, The First Affiliated Hospital of Anhui Medical University, 
      Hefei, China.
FAU - Luo, Qingquan
AU  - Luo Q
AD  - Shanghai Institute of Immunology and Shanghai Chest Hospital, Shanghai Jiao Tong 
      University School of Medicine, Shanghai, China.
FAU - Jin, Min
AU  - Jin M
AD  - Key Laboratory of Stem Cell Biology, Institute of Health Sciences, Shanghai 
      Institutes for Biological Sciences, Chinese Academy of Sciences and Shanghai Jiao 
      Tong University School of Medicine, Shanghai, China.
FAU - Zhou, Qianjun
AU  - Zhou Q
AD  - Shanghai Institute of Immunology and Shanghai Chest Hospital, Shanghai Jiao Tong 
      University School of Medicine, Shanghai, China.
FAU - Zhang, Yanyun
AU  - Zhang Y
AD  - Shanghai Institute of Immunology and Shanghai Chest Hospital, Shanghai Jiao Tong 
      University School of Medicine, Shanghai, China.
AD  - Key Laboratory of Stem Cell Biology, Institute of Health Sciences, Shanghai 
      Institutes for Biological Sciences, Chinese Academy of Sciences and Shanghai Jiao 
      Tong University School of Medicine, Shanghai, China.
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PL  - United States
TA  - Aging (Albany NY)
JT  - Aging
JID - 101508617
RN  - 0 (Chemokines, CXC)
RN  - 0 (Cxcl7 protein, mouse)
RN  - 0 (Reactive Oxygen Species)
SB  - IM
MH  - Age Factors
MH  - Aging/*metabolism/pathology
MH  - Animals
MH  - *Cell Proliferation
MH  - Cells, Cultured
MH  - Chemokines, CXC/metabolism
MH  - Hepatic Stellate Cells/metabolism
MH  - Liver/*metabolism/pathology
MH  - *Liver Regeneration
MH  - Mice, Inbred C57BL
MH  - Neutrophil Infiltration
MH  - Neutrophils/metabolism
MH  - *Oxidative Stress
MH  - Paracrine Communication
MH  - Phenotype
MH  - Reactive Oxygen Species/*metabolism
MH  - Stem Cell Niche
MH  - Stem Cells/*metabolism/pathology
MH  - Time Factors
PMC - PMC5472737
OTO - NOTNLM
OT  - aging
OT  - liver regeneration
OT  - neutrophil
OT  - reactive oxygen species
OT  - stem cells
COIS- CONFLICTS OF INTEREST The authors declare that there is no conflict of interest.
EDAT- 2017/05/02 06:00
MHDA- 2018/03/23 06:00
PMCR- 2017/05/01
CRDT- 2017/05/02 06:00
PHST- 2017/04/01 00:00 [received]
PHST- 2017/04/23 00:00 [accepted]
PHST- 2017/05/02 06:00 [pubmed]
PHST- 2018/03/23 06:00 [medline]
PHST- 2017/05/02 06:00 [entrez]
PHST- 2017/05/01 00:00 [pmc-release]
AID - 101232 [pii]
AID - 10.18632/aging.101232 [doi]
PST - ppublish
SO  - Aging (Albany NY). 2017 Apr 29;9(5):1359-1374. doi: 10.18632/aging.101232.