PMID- 28458423
OWN - NLM
STAT- MEDLINE
DCOM- 20171229
LR  - 20181113
IS  - 1998-3751 (Electronic)
IS  - 0253-7613 (Print)
IS  - 0253-7613 (Linking)
VI  - 49
IP  - 1
DP  - 2017 Jan-Feb
TI  - Effect of Angelica glauca essential oil on allergic airway changes induced by 
      histamine and ovalbumin in experimental animals.
PG  - 55-59
LID - 10.4103/0253-7613.201019 [doi]
AB  - OBJECTIVE: Angelica glauca Edgew (Apiaceae) is used in traditional medicine for 
      treatment of several diseases including bronchial asthma. The present 
      investigation was aimed to evaluate broncho-relaxant activity of A. glauca 
      essential oil in histamine and ovalbumin (OVA)-induced broncho constriction in 
      experimental animals. MATERIALS AND METHODS: Airway was induced using histamine 
      aerosol in guinea pigs (n = 24) and OVA aerosol in albino mice (n = 24). The 
      number of inflammatory cells, namely, absolute eosinophils count in blood, total 
      immunoglobulin E (IgE) in serum, eosinophils, and neutrophils in bronchoalveolar 
      lavage fluid (BALF) and histopathological examination of lung tissues were 
      investigated in A. glauca oil and dexamethasone-treated groups. A. glauca oil 200 
      muL/kg was given orally, and dexamethasone 2 mg/kg was given intraperitoneal. Both 
      the treatments were repeated daily for 7 days. Results were analyzed by one-way 
      ANOVA, and P </= 0.05 was considered statistically significant. RESULTS: Treatment 
      with A. glauca essential oil significantly (P < 0.001) increased the time of 
      preconvulsive dyspnea in histamine-induced guinea pigs. Oral treatment of A. 
      glauca oil significantly (P < 0.001) decreased absolute blood eosinophil count 
      (from 325 +/- 3.69 to 200 +/- 3.05 cells/mm(3)), serum level of IgE (from 6.10 +/- 0.05 
      to 0.70 +/- 0.08 IU/L), and the number of eosinophils (from 11.0% +/-1.41% to 3.0% 
      +/-0.51%), neutrophils (from 13.0% +/-1.12% to 5.0% +/-1.39%) in BALF. 
      Histopathological changes observed in lungs of untreated group were marked 
      suppressed by treatment with A. glauca oil. CONCLUSION: The essential oil of A. 
      glauca has bronchorelaxation in both histamine and OVA-induced 
      bronchoconstriction in animals. The traditional use of A. glauca against asthma 
      could be attributed to its bronchodilator property as observed in the present 
      study.
FAU - Sharma, Shilpa
AU  - Sharma S
AD  - Department of Pharmacology, KLE University, College of Pharmacy, Belgaum, 
      Karnataka, India.
FAU - Rasal, Vijaykumar P
AU  - Rasal VP
AD  - Department of Pharmacology, KLE University, College of Pharmacy, Belgaum, 
      Karnataka, India.
FAU - Patil, Paragouda A
AU  - Patil PA
AD  - Department of Pharmacology, USM KLE International Medical Programme, Belgaum, 
      Karnataka, India.
FAU - Joshi, Rajesh K
AU  - Joshi RK
AD  - Department of Phytochemistry, Regional Medical Research Centre, Indian Council of 
      Medical Research, Belgaum, Karnataka, India.
LA  - eng
PT  - Comparative Study
PT  - Journal Article
PL  - India
TA  - Indian J Pharmacol
JT  - Indian journal of pharmacology
JID - 7902477
RN  - 0 (Bronchodilator Agents)
RN  - 0 (Oils, Volatile)
RN  - 37341-29-0 (Immunoglobulin E)
RN  - 7S5I7G3JQL (Dexamethasone)
RN  - 820484N8I3 (Histamine)
RN  - 9006-59-1 (Ovalbumin)
SB  - IM
MH  - Administration, Oral
MH  - Angelica/*chemistry
MH  - Animals
MH  - Asthma/drug therapy/immunology
MH  - Bronchoalveolar Lavage Fluid
MH  - Bronchoconstriction/*drug effects/immunology
MH  - Bronchodilator Agents/administration & dosage/isolation & 
      purification/*pharmacology
MH  - Dexamethasone/pharmacology
MH  - Disease Models, Animal
MH  - Eosinophils/drug effects/metabolism
MH  - Female
MH  - Guinea Pigs
MH  - Histamine/immunology
MH  - Immunoglobulin E/blood
MH  - Mice
MH  - Neutrophils/drug effects/metabolism
MH  - Oils, Volatile/administration & dosage/isolation & purification/*pharmacology
MH  - Ovalbumin/immunology
PMC - PMC5351239
OTO - NOTNLM
OT  - Angelica glauca
OT  - bronchorelaxation
OT  - histamine
OT  - ovalbumin
COIS- There are no conflicts of interest.
EDAT- 2017/05/02 06:00
MHDA- 2017/12/30 06:00
PMCR- 2017/01/01
CRDT- 2017/05/02 06:00
PHST- 2017/05/02 06:00 [entrez]
PHST- 2017/05/02 06:00 [pubmed]
PHST- 2017/12/30 06:00 [medline]
PHST- 2017/01/01 00:00 [pmc-release]
AID - IJPharm-49-55 [pii]
AID - 10.4103/0253-7613.201019 [doi]
PST - ppublish
SO  - Indian J Pharmacol. 2017 Jan-Feb;49(1):55-59. doi: 10.4103/0253-7613.201019.