PMID- 28459012
OWN - NLM
STAT- PubMed-not-MEDLINE
LR  - 20201001
IS  - 2229-5070 (Print)
IS  - 2229-7758 (Electronic)
IS  - 2229-5070 (Linking)
VI  - 7
IP  - 1
DP  - 2017 Jan-Jun
TI  - Stage-specific antibody response against two larval stages of Brugia malayi in 
      different clinical spectra of brugian filariasis.
PG  - 29-36
LID - 10.4103/2229-5070.202298 [doi]
AB  - CONTEXT: T-cell hypo-responsiveness in microfilaria (Mf) carriers against the 
      microfilarial stage antigen of Brugia malayi has been described, but no study has 
      been carried out to assess antibody dynamics against stage-specific antigens. 
      AIM: The work was carried out with the aim to assess stage-specific antibody 
      responses against L3 and microfilarial stage antigens in brugian filariasis in an 
      endemic area. SETTING AND DESIGN: Patients with different clinical spectra of 
      brugian filariasis were recruited to evaluate antibody responses to brugian 
      antigens. SUBJECTS AND METHODS: Serum samples were collected from patients with 
      different clinical spectra and antibody response was evaluated for total 
      immunoglobulin G (IgG), IgG isotypes (IgG1, IgG2, IgG3, IgG4) and immunoglobulin 
      E (IgE) response to L3 and microfilarial stage by enzyme-linked immunosorbent 
      assay. STATISTICAL ANALYSIS: Paired t-test and one-way analysis of variance were 
      carried out to analyze the data. RESULTS: L3 and microfilarial stage antigens 
      showed almost similar antibody responses in adenolymphangitis (ADL) and chronic 
      pathology (CP) patients, however, diminished antibody response was observed with 
      Mf stage antigen, especially with microfilaraemia. ADL patients had minimum 
      antibody levels of all isotypes except IgG2 on day 0 which showed an increase 
      subsequently, indicating suppression of antibody response during filarial fever. 
      CP patients showed increase in IgE and decrease in IgG4 antibodies on day 365 
      indicating that these differences may be due to recent conversion into CP. 
      CONCLUSION: A prominent hyporesponsiveness in microfilaraemic individuals against 
      microfilarial stage, but not against the L3 stage of the same parasite was 
      observed, concluding stage-specificity in humoral immune response in brugian 
      filariasis.
FAU - Tripathi, Praveen Kumar
AU  - Tripathi PK
AD  - Department of Medical Parasitology, Postgraduate Institute of Medical Education 
      and Research, Chandigarh, India.
FAU - Mahajan, Ramesh Chander
AU  - Mahajan RC
AD  - Department of Medical Parasitology, Postgraduate Institute of Medical Education 
      and Research, Chandigarh, India.
FAU - Malla, Nancy
AU  - Malla N
AD  - Department of Medical Parasitology, Postgraduate Institute of Medical Education 
      and Research, Chandigarh, India.
FAU - Kumar, Naveen
AU  - Kumar N
AD  - Department of Medical Parasitology, Postgraduate Institute of Medical Education 
      and Research, Chandigarh, India.
FAU - Bhattacharya, Shailja Misra
AU  - Bhattacharya SM
AD  - Division of Parasitology, CDRI, Lucknow, Uttar Pradesh, India.
FAU - Shinoy, Ranganatha Krishna
AU  - Shinoy RK
AD  - Department of Medicine, Filariasis Chemotherapy Unit, TD Medical College 
      Hospital, Alappuzha, Kerala, India.
FAU - Mewara, Abhishek
AU  - Mewara A
AD  - Department of Medical Parasitology, Postgraduate Institute of Medical Education 
      and Research, Chandigarh, India.
FAU - Sehgal, Rakesh
AU  - Sehgal R
AD  - Department of Medical Parasitology, Postgraduate Institute of Medical Education 
      and Research, Chandigarh, India.
LA  - eng
PT  - Journal Article
PL  - India
TA  - Trop Parasitol
JT  - Tropical parasitology
JID - 101580198
PMC - PMC5369271
OTO - NOTNLM
OT  - Brugian filariasis
OT  - L3 and microfilarial antigens
OT  - stage-specific antibody responses
EDAT- 2017/05/02 06:00
MHDA- 2017/05/02 06:01
PMCR- 2017/01/01
CRDT- 2017/05/02 06:00
PHST- 2017/05/02 06:00 [entrez]
PHST- 2017/05/02 06:00 [pubmed]
PHST- 2017/05/02 06:01 [medline]
PHST- 2017/01/01 00:00 [pmc-release]
AID - TP-7-29 [pii]
AID - 10.4103/2229-5070.202298 [doi]
PST - ppublish
SO  - Trop Parasitol. 2017 Jan-Jun;7(1):29-36. doi: 10.4103/2229-5070.202298.