PMID- 28459817
OWN - NLM
STAT- MEDLINE
DCOM- 20170720
LR  - 20190202
IS  - 1935-2735 (Electronic)
IS  - 1935-2727 (Print)
IS  - 1935-2727 (Linking)
VI  - 11
IP  - 5
DP  - 2017 May
TI  - Modulation of Mycobacterium tuberculosis-specific humoral immune responses is 
      associated with Strongyloides stercoralis co-infection.
PG  - e0005569
LID - 10.1371/journal.pntd.0005569 [doi]
LID - e0005569
AB  - BACKGROUND / OBJECTIVES: Helminth infections are known to influence T cell 
      responses in latent tuberculosis (LTBI). Whether helminth infections also 
      modulate B cell responses in helminth-tuberculosis co-infection is not known. 
      METHODS: We assessed Mycobacterium tuberculosis (Mtb)-antigen specific IgM and 
      IgG levels, circulating levels of the B cell growth factors, BAFF and APRIL and 
      the absolute numbers of the various B cell subsets in individuals with LTBI, LTBI 
      with coincident Strongyloides stercoralis (Ss) infection (LTBI/Ss) and in those 
      with Ss infection alone (Ss). We also measured the above-mentioned parameters in 
      the LTBI-Ss group after anthelmintic therapy. RESULTS: Our data reveal that 
      LTBI-Ss exhibit significantly diminished levels of Mtb-specific IgM and IgG, BAFF 
      and APRIL levels in comparison to those with LTBI. Similarly, those with LTBI-Ss 
      had significantly diminished numbers of all B cell subsets (naive, immature, 
      classical memory, activated memory, atypical memory and plasma cells) compared to 
      those with LTBI. There was a positive correlation between Mtb-antigen specific 
      IgM and IgG levels and BAFF and APRIL levels that were in turn related to the 
      numbers of activated memory B cells, atypical memory B cells and plasma cells. 
      Finally, anthelmintic treatment resulted in significantly increased levels of 
      Mtb-antigen specific IgM and IgG levels and the numbers of each of the B cell 
      subsets. CONCLUSIONS: Our data, therefore, reveal that Ss infection is associated 
      with significant modulation of Mtb-specific antibody responses, the levels of B 
      cell growth factors and the numbers of B cells (and their component subsets).
FAU - Anuradha, Rajamanickam
AU  - Anuradha R
AD  - National Institutes of Health-NIRT-International Center for Excellence in 
      Research, Chennai, India.
FAU - Munisankar, Saravanan
AU  - Munisankar S
AD  - National Institutes of Health-NIRT-International Center for Excellence in 
      Research, Chennai, India.
FAU - Bhootra, Yukti
AU  - Bhootra Y
AD  - National Institutes of Health-NIRT-International Center for Excellence in 
      Research, Chennai, India.
FAU - Dolla, Chandrakumar
AU  - Dolla C
AD  - National Institute for Research in Tuberculosis, Chennai, India.
FAU - Kumaran, Paul
AU  - Kumaran P
AD  - National Institute for Research in Tuberculosis, Chennai, India.
FAU - Nutman, Thomas B
AU  - Nutman TB
AD  - Laboratory of Parasitic Diseases, National Institutes of Allergy and Infectious 
      Diseases, National Institutes of Health, Bethesda, Maryland, United States of 
      America.
FAU - Babu, Subash
AU  - Babu S
AUID- ORCID: 0000-0001-9783-8042
AD  - National Institutes of Health-NIRT-International Center for Excellence in 
      Research, Chennai, India.
AD  - Laboratory of Parasitic Diseases, National Institutes of Allergy and Infectious 
      Diseases, National Institutes of Health, Bethesda, Maryland, United States of 
      America.
LA  - eng
PT  - Journal Article
DEP - 20170501
PL  - United States
TA  - PLoS Negl Trop Dis
JT  - PLoS neglected tropical diseases
JID - 101291488
RN  - 0 (Antibodies, Bacterial)
RN  - 0 (B-Cell Activating Factor)
RN  - 0 (Cytokines)
RN  - 0 (Immunoglobulin G)
RN  - 0 (Immunoglobulin M)
RN  - 0 (TNFSF13 protein, human)
RN  - 0 (TNFSF13B protein, human)
RN  - 0 (Tumor Necrosis Factor Ligand Superfamily Member 13)
SB  - IM
MH  - Adult
MH  - Animals
MH  - Antibodies, Bacterial/blood
MH  - B-Cell Activating Factor/blood
MH  - B-Lymphocyte Subsets/*immunology
MH  - Coinfection/*immunology
MH  - Cytokines/immunology
MH  - Female
MH  - Humans
MH  - *Immunity, Humoral
MH  - Immunoglobulin G/blood
MH  - Immunoglobulin M/blood
MH  - India
MH  - Latent Tuberculosis/*immunology
MH  - Male
MH  - Middle Aged
MH  - Mycobacterium tuberculosis
MH  - Strongyloides stercoralis
MH  - Strongyloidiasis/*immunology
MH  - Tumor Necrosis Factor Ligand Superfamily Member 13/blood
MH  - Young Adult
PMC - PMC5426788
COIS- The authors have declared that no competing interests exist.
EDAT- 2017/05/02 06:00
MHDA- 2017/07/21 06:00
PMCR- 2017/05/01
CRDT- 2017/05/02 06:00
PHST- 2017/01/06 00:00 [received]
PHST- 2017/04/14 00:00 [accepted]
PHST- 2017/05/11 00:00 [revised]
PHST- 2017/05/02 06:00 [pubmed]
PHST- 2017/07/21 06:00 [medline]
PHST- 2017/05/02 06:00 [entrez]
PHST- 2017/05/01 00:00 [pmc-release]
AID - PNTD-D-17-00020 [pii]
AID - 10.1371/journal.pntd.0005569 [doi]
PST - epublish
SO  - PLoS Negl Trop Dis. 2017 May 1;11(5):e0005569. doi: 10.1371/journal.pntd.0005569. 
      eCollection 2017 May.