PMID- 28459968
OWN - NLM
STAT- MEDLINE
DCOM- 20170913
LR  - 20200117
IS  - 1476-6256 (Electronic)
IS  - 0002-9262 (Print)
IS  - 0002-9262 (Linking)
VI  - 186
IP  - 2
DP  - 2017 Jul 15
TI  - Human Leukocyte Antigen Shared Epitope and Inflammation, Cardiovascular Disease, 
      Cancer, and Mortality Among Postmenopausal Women in the Women's Health Initiative 
      Rheumatoid Arthritis Study.
PG  - 245-254
LID - 10.1093/aje/kwx087 [doi]
AB  - Specific alleles of the human leukocyte antigen (HLA)-DRB1 gene (HLA-DRB1) encode 
      a "shared epitope" (SE) associated with rheumatoid arthritis (RA), especially 
      more severe cyclic-citrullinated peptide antibody-positive (anti-CCP+) RA. We 
      evaluated associations of number of SE alleles (0, 1, or 2) with total and 
      cardiovascular disease (CVD) mortality and incident coronary heart disease (CHD), 
      CVD, and cancer over a mean 8.9 (standard deviation, 3.5) years of follow-up, 
      stratifying by baseline anti-CCP status (positive (+) vs. negative (-)). A 
      longitudinal study, the Women's Health Initiative RA Study (1993-2010), sampled 
      postmenopausal women who reported RA at baseline (1993-1998) or follow-up in the 
      Women's Health Initiative, classified as anti-CCP+ RA (n = 556) or anti-CCP- 
      non-RA (n = 1,070). Among anti-CCP+ RA women, SE alleles were not related to 
      age-adjusted risks of CHD, CVD, or cancer or to total or CVD mortality. Among 
      anti-CCP- non-RA women, age-adjusted hazard ratios for 1 and 2 SE alleles versus 
      0 SE alleles were 0.41 (95% confidence interval (CI): 0.34, 0.50) and 0.44 (95% 
      CI: 0.27, 0.72), respectively, for CVD; 0.43 (95% CI: 0.37, 0.53) and 0.30 (95% 
      CI: 0.16, 0.64), respectively, for CHD; and 0.62 (95% CI: 0.53, 0.73) and 0.52 
      (95% CI: 0.33, 0.83), respectively, for cancer. Associations persisted after 
      adjustment for CVD risk factors, joint pain, rheumatoid factor positivity, and 
      inflammatory markers (white blood cell count or cytokine level). In future 
      studies, investigators should evaluate SE associations among anti-CCP- adults 
      without RA and potential mechanisms.
CI  - (c) The Author(s) 2017. Published by Oxford University Press on behalf of the Johns 
      Hopkins Bloomberg School of Public Health. All rights reserved. For permissions, 
      please e-mail: journals.permissions@oup.com.
FAU - Birru Talabi, Mehret
AU  - Birru Talabi M
FAU - Mackey, Rachel H
AU  - Mackey RH
FAU - Kuller, Lewis H
AU  - Kuller LH
FAU - Dorman, Janice S
AU  - Dorman JS
FAU - Deane, Kevin D
AU  - Deane KD
FAU - Robinson, William H
AU  - Robinson WH
FAU - Walitt, Brian T
AU  - Walitt BT
FAU - Chang, Yuefang
AU  - Chang Y
FAU - Holers, V Michael
AU  - Holers VM
FAU - Liu, Simin
AU  - Liu S
FAU - Moreland, Larry W
AU  - Moreland LW
LA  - eng
GR  - HHSN268201600002C/HL/NHLBI NIH HHS/United States
GR  - HHSN268201600018C/HL/NHLBI NIH HHS/United States
GR  - HHSN268201600003C/HL/NHLBI NIH HHS/United States
GR  - HHSN268201600004C/HL/NHLBI NIH HHS/United States
GR  - T32 AI089443/AI/NIAID NIH HHS/United States
GR  - HHSN268201600001C/HL/NHLBI NIH HHS/United States
PT  - Journal Article
PL  - United States
TA  - Am J Epidemiol
JT  - American journal of epidemiology
JID - 7910653
RN  - 0 (Biomarkers)
RN  - 0 (Epitopes)
RN  - 0 (HLA Antigens)
SB  - IM
MH  - Aged
MH  - Alleles
MH  - Arthritis, Rheumatoid/epidemiology/*genetics/immunology
MH  - Biomarkers
MH  - Cardiovascular Diseases/epidemiology/*genetics/immunology/mortality
MH  - Comorbidity
MH  - Coronary Disease/epidemiology/genetics/immunology
MH  - Epitopes/genetics
MH  - Female
MH  - *Genetic Predisposition to Disease
MH  - HLA Antigens/*genetics/immunology
MH  - Humans
MH  - Incidence
MH  - Inflammation/epidemiology/genetics/immunology
MH  - Longitudinal Studies
MH  - Middle Aged
MH  - Neoplasms/epidemiology/*genetics
MH  - Postmenopause
MH  - Prevalence
MH  - Proportional Hazards Models
MH  - Women's Health/statistics & numerical data
PMC - PMC5860272
OTO - NOTNLM
OT  - HLA-DRB1 gene
OT  - cancer
OT  - cardiovascular disease
OT  - human leukocyte antigen
OT  - mortality
OT  - rheumatoid arthritis
OT  - shared epitope
EDAT- 2017/05/02 06:00
MHDA- 2017/09/14 06:00
PMCR- 2018/07/15
CRDT- 2017/05/02 06:00
PHST- 2016/05/04 00:00 [received]
PHST- 2016/08/31 00:00 [accepted]
PHST- 2017/05/02 06:00 [pubmed]
PHST- 2017/09/14 06:00 [medline]
PHST- 2017/05/02 06:00 [entrez]
PHST- 2018/07/15 00:00 [pmc-release]
AID - 3778488 [pii]
AID - kwx087 [pii]
AID - 10.1093/aje/kwx087 [doi]
PST - ppublish
SO  - Am J Epidemiol. 2017 Jul 15;186(2):245-254. doi: 10.1093/aje/kwx087.