PMID- 28461003
OWN - NLM
STAT- MEDLINE
DCOM- 20170713
LR  - 20170713
IS  - 1347-8648 (Electronic)
IS  - 1347-8613 (Linking)
VI  - 134
IP  - 1
DP  - 2017 May
TI  - Ginsenoside Rg3 exerts anti-depressive effect on an NMDA-treated cell model and a 
      chronic mild stress animal model.
PG  - 45-54
LID - S1347-8613(17)30053-1 [pii]
LID - 10.1016/j.jphs.2017.03.007 [doi]
AB  - Depression is a common mental disorder and a leading cause of disability. At its 
      most severe, it can lead to suicide. Recently, there has been growing interest in 
      the application of natural herbs for the prevention and treatment of depression. 
      In this report, we found that the ginsenoside active component Rg3 has an 
      apparent antidepressant effect. In N-methyl-d-aspartic acid (NMDA)-treated HT22 
      murine hippocampal neuronal cells, Rg3 recovered proliferation and inhibited 
      apoptosis by altering the cell cycle. More interestingly, Rg3 led to apparent 
      physiological behavior change in a chronic mild stress model as seen in forced 
      swim, tail suspension, and sucrose preference tests. This effect was mediated by 
      the phosphorylation of cAMP response element binding protein (CREB) and 
      brain-derived neurotrophic factor (BDNF) signaling. This study provides direct 
      evidence to support the antidepressant effects of ginsenoside Rg3, potentially 
      indicating its application in the treatment of clinical depression.
CI  - Copyright (c) 2017 The Authors. Production and hosting by Elsevier B.V. All rights 
      reserved.
FAU - Zhang, Hualin
AU  - Zhang H
AD  - School of Chemistry and Chemical Engineering, Lingnan Normal University, 
      Zhanjiang 524048, China.
FAU - Zhou, Zhongliu
AU  - Zhou Z
AD  - School of Chemistry and Chemical Engineering, Lingnan Normal University, 
      Zhanjiang 524048, China.
FAU - Chen, Ziming
AU  - Chen Z
AD  - School of Chemistry and Chemical Engineering, Lingnan Normal University, 
      Zhanjiang 524048, China.
FAU - Zhong, Zhiyong
AU  - Zhong Z
AD  - Guangdong Medical Laboratory Animal Center, Guangzhou 528248, China.
FAU - Li, Zhong
AU  - Li Z
AD  - Department of Neurology, The Sixth Affiliated Hospital of Sun Yat-Sen University, 
      Guangzhou 510655, China; Shenzhen Research Institute of Sun Yat-Sen University, 
      China; Guangdong Provincial Key Laboratory of Brain Function and Disease, China. 
      Electronic address: lzhong@mail.sysu.edu.cn.
LA  - eng
PT  - Journal Article
DEP - 20170412
PL  - Japan
TA  - J Pharmacol Sci
JT  - Journal of pharmacological sciences
JID - 101167001
RN  - 0 (Antidepressive Agents)
RN  - 0 (Brain-Derived Neurotrophic Factor)
RN  - 0 (Cyclic AMP Response Element-Binding Protein)
RN  - 0 (Ginsenosides)
RN  - 227D367Y57 (ginsenoside Rg3)
RN  - 6384-92-5 (N-Methylaspartate)
SB  - IM
MH  - Animals
MH  - Antidepressive Agents/chemistry/metabolism/*pharmacology
MH  - Brain-Derived Neurotrophic Factor/metabolism
MH  - Cyclic AMP Response Element-Binding Protein/metabolism
MH  - Depression/*drug therapy
MH  - Disease Models, Animal
MH  - Female
MH  - Ginsenosides/chemistry/metabolism/*pharmacology
MH  - Hippocampus/cytology
MH  - Humans
MH  - Mental Disorders
MH  - Mice
MH  - Mice, Inbred C57BL
MH  - N-Methylaspartate/pharmacology
MH  - Neurons/cytology/*drug effects/metabolism
MH  - Phosphorylation
MH  - Signal Transduction/drug effects
MH  - Stress, Psychological/*drug therapy
OTO - NOTNLM
OT  - Chronic mild stress model
OT  - Depression
OT  - Ginsenoside Rg3
OT  - HT22 cells
EDAT- 2017/05/04 06:00
MHDA- 2017/07/14 06:00
CRDT- 2017/05/03 06:00
PHST- 2017/01/11 00:00 [received]
PHST- 2017/03/29 00:00 [revised]
PHST- 2017/03/31 00:00 [accepted]
PHST- 2017/05/04 06:00 [pubmed]
PHST- 2017/07/14 06:00 [medline]
PHST- 2017/05/03 06:00 [entrez]
AID - S1347-8613(17)30053-1 [pii]
AID - 10.1016/j.jphs.2017.03.007 [doi]
PST - ppublish
SO  - J Pharmacol Sci. 2017 May;134(1):45-54. doi: 10.1016/j.jphs.2017.03.007. Epub 
      2017 Apr 12.