PMID- 28461705
OWN - NLM
STAT- MEDLINE
DCOM- 20180702
LR  - 20180702
IS  - 1804-7521 (Electronic)
IS  - 1213-8118 (Linking)
VI  - 161
IP  - 3
DP  - 2017 Sep
TI  - Higher levels of matrix metalloproteinase-3 in patients with RA reflect disease 
      activity and structural damage.
PG  - 296-302
LID - 10.5507/bp.2017.015 [doi]
AB  - AIMS: To evaluate the serum levels of matrix metalloproteinase-3 (MMP-3) as a 
      potential marker of disease activity and joint damage in 92 patients with 
      rheumatoid arthritis (RA), compared to 24 osteoarthritis (OA) patients and 26 
      healthy controls. METHODS: The concentrations of MMP-3 were measured by ELISA 
      using the commercial kit AESKULISA DF MMP-3 (AESKU.Diagnostics, Germany) and 
      compared with other laboratory parameters routinely used to assess the disease 
      status, clinical score (DAS28) and radiographic stage in the group of RA 
      patients. RESULTS: The mean serum concentrations of MMP-3 were 199.1 +/- 160 ng/mL 
      in RA patients, 113.9 +/- 96.9 ng/mL in OA patients and 48.3 +/- 19.2 in healthy 
      controls. The differences were highly significant: RA patients and healthy 
      controls (P<0.0001), RA and OA patients (P=0.008) as well as between OA patients 
      and controls (P=0.009). MMP-3 concentrations were further compared with other 
      laboratory parameters and clinical and structural damage data. There were 
      correlations between MMP-3 and CRP (r=0.304, P<0.01), DAS28 (r=0.301, P<0.05), 
      levels of anti-cyclic citrullinated peptide antibodies (r=0.241, P<0.05), 
      erythrocyte sedimentation rate (r=0.200, P=0.059) and radiographic disease stage 
      (r=0.197, P=0.063). CONCLUSION: These results demonstrated that measurement of 
      MMP-3 could become a marker of disease activity in RA patients.
FAU - Skacelova, Martina
AU  - Skacelova M
AD  - Department of Internal Medicine III - Nephrology, Rheumatology and Endocrinology, 
      Faculty of Medicine and Dentistry, Palacky University Olomouc, Czech Republic.
FAU - Hermanova, Zuzana
AU  - Hermanova Z
AD  - Department of Immunology, Faculty of Medicine and Dentistry, Palacky University 
      Olomouc, Czech Republic.
FAU - Horak, Pavel
AU  - Horak P
AD  - Department of Internal Medicine III - Nephrology, Rheumatology and Endocrinology, 
      Faculty of Medicine and Dentistry, Palacky University Olomouc, Czech Republic.
FAU - Ahmed, Kazi
AU  - Ahmed K
AD  - Department of Internal Medicine III - Nephrology, Rheumatology and Endocrinology, 
      Faculty of Medicine and Dentistry, Palacky University Olomouc, Czech Republic.
FAU - Langova, Katerina
AU  - Langova K
AD  - Department of Medical Biophysics, Faculty of Medicine and Dentistry, Palacky 
      University Olomouc, Czech Republic.
LA  - eng
PT  - Comparative Study
PT  - Journal Article
DEP - 20170426
PL  - Czech Republic
TA  - Biomed Pap Med Fac Univ Palacky Olomouc Czech Repub
JT  - Biomedical papers of the Medical Faculty of the University Palacky, Olomouc, 
      Czechoslovakia
JID - 101140142
RN  - 0 (Biomarkers)
RN  - 9009-79-4 (Rheumatoid Factor)
RN  - EC 3.4.24.17 (MMP3 protein, human)
RN  - EC 3.4.24.17 (Matrix Metalloproteinase 3)
SB  - IM
MH  - Arthritis, Rheumatoid/diagnostic imaging/*enzymology/*pathology/physiopathology
MH  - Biomarkers/blood
MH  - Blood Sedimentation
MH  - Cross-Sectional Studies
MH  - Disease Progression
MH  - Enzyme-Linked Immunosorbent Assay
MH  - Female
MH  - Humans
MH  - Male
MH  - Matrix Metalloproteinase 3/*blood
MH  - Middle Aged
MH  - Osteoarthritis/diagnostic imaging/*enzymology/*pathology/physiopathology
MH  - Predictive Value of Tests
MH  - Radiography
MH  - Rheumatoid Factor/blood
OTO - NOTNLM
OT  - disease activity
OT  - matrix metalloproteinase-3
OT  - rheumatoid arthritis
EDAT- 2017/05/04 06:00
MHDA- 2018/07/03 06:00
CRDT- 2017/05/03 06:00
PHST- 2016/12/12 00:00 [received]
PHST- 2017/03/22 00:00 [accepted]
PHST- 2017/05/04 06:00 [pubmed]
PHST- 2018/07/03 06:00 [medline]
PHST- 2017/05/03 06:00 [entrez]
AID - 10.5507/bp.2017.015 [doi]
PST - ppublish
SO  - Biomed Pap Med Fac Univ Palacky Olomouc Czech Repub. 2017 Sep;161(3):296-302. 
      doi: 10.5507/bp.2017.015. Epub 2017 Apr 26.