PMID- 28461769
OWN - NLM
STAT- PubMed-not-MEDLINE
LR  - 20201001
IS  - 1226-4512 (Print)
IS  - 2093-3827 (Electronic)
IS  - 1226-4512 (Linking)
VI  - 21
IP  - 3
DP  - 2017 May
TI  - Identification of AMPK activator from twelve pure compounds isolated from Aralia 
      Taibaiensis: implication in antihyperglycemic and hypolipidemic activities.
PG  - 279-286
LID - 10.4196/kjpp.2017.21.3.279 [doi]
AB  - The root bark extract of Aralia taibaiensis is used traditionally for the 
      treatment of diabetes mellitus in China. The total saponin extracted from Aralia 
      Taibaiensis (sAT) has effective combined antihyperglycemic and hypolipidemic 
      activities in experimental type 2 diabetic rats. However, the active compounds 
      have not yet been fully investigated. In the present study, we examined effects 
      of twelve triterpenoid saponins on AMP-activated protein kinase (AMPK) 
      activation, and found that compound 28-O-beta-D-glucopyranosyl ester (AT12) 
      significantly increased phosphorylation of AMPK and Acetyl-CoA carboxylase (ACC). 
      AT12 effectively decreased blood glucose, triglyceride (TG), free fatty acid 
      (FFA) and low density lipoprotein-cholesterol (LDL-C) levels in the rat model of 
      type 2 diabetes mellitus (T2DM). The mechanism by which AT12 activated AMPK was 
      subsequently investigated. Intracellular ATP level and oxygen consumption were 
      significantly reduced by AT12 treatment. The findings suggested AT12 was a novel 
      AMPK activator, and could be useful for the treatment of metabolic diseases.
FAU - Li, Yuwen
AU  - Li Y
AD  - Department of Pharmacy, Xijing Hospital, Fourth Military Medical University, Xi' 
      an 710032, P. R. China.
FAU - Park, Jongsun
AU  - Park J
AD  - Department of Pharmacology, Chungnam National University, Daejon 34134, Korea.
FAU - Wu, Yin
AU  - Wu Y
AD  - Department of Pharmacy, Xijing Hospital, Fourth Military Medical University, Xi' 
      an 710032, P. R. China.
FAU - Cui, Jia
AU  - Cui J
AD  - Department of Pharmacy, Xijing Hospital, Fourth Military Medical University, Xi' 
      an 710032, P. R. China.
FAU - Jia, Na
AU  - Jia N
AD  - Department of Pharmacy, Xijing Hospital, Fourth Military Medical University, Xi' 
      an 710032, P. R. China.
FAU - Xi, Miaomiao
AU  - Xi M
AD  - Department of Pharmacy, Xijing Hospital, Fourth Military Medical University, Xi' 
      an 710032, P. R. China.
FAU - Wen, Aidong
AU  - Wen A
AD  - Department of Pharmacy, Xijing Hospital, Fourth Military Medical University, Xi' 
      an 710032, P. R. China.
LA  - eng
PT  - Journal Article
DEP - 20170421
PL  - Korea (South)
TA  - Korean J Physiol Pharmacol
JT  - The Korean journal of physiology & pharmacology : official journal of the Korean 
      Physiological Society and the Korean Society of Pharmacology
JID - 9709505
PMC - PMC5409114
OTO - NOTNLM
OT  - 28-O-beta-D-glucopyranosyl ester (AT12)
OT  - AMPK
OT  - Antihyperglycemic activity
OT  - Hypolipidemic activity
OT  - T2DM
COIS- Conflicts of interest: The authors declare no conflicts of interest.
EDAT- 2017/05/04 06:00
MHDA- 2017/05/04 06:01
PMCR- 2017/05/01
CRDT- 2017/05/03 06:00
PHST- 2014/08/30 00:00 [received]
PHST- 2015/07/09 00:00 [revised]
PHST- 2015/10/21 00:00 [accepted]
PHST- 2017/05/03 06:00 [entrez]
PHST- 2017/05/04 06:00 [pubmed]
PHST- 2017/05/04 06:01 [medline]
PHST- 2017/05/01 00:00 [pmc-release]
AID - 10.4196/kjpp.2017.21.3.279 [doi]
PST - ppublish
SO  - Korean J Physiol Pharmacol. 2017 May;21(3):279-286. doi: 
      10.4196/kjpp.2017.21.3.279. Epub 2017 Apr 21.