PMID- 28462216
OWN - NLM
STAT- PubMed-not-MEDLINE
LR  - 20201001
IS  - 2305-5839 (Print)
IS  - 2305-5847 (Electronic)
IS  - 2305-5839 (Linking)
VI  - 5
IP  - 6
DP  - 2017 Mar
TI  - Efficacy and safety of Danggui Buxue Decoction in combination with western 
      medicine treatment of anemia for renal anemia: a systematic review and 
      meta-analysis.
PG  - 136
LID - 10.21037/atm.2017.01.17 [doi]
LID - 136
AB  - BACKGROUND: To evaluate the efficacy and safety of Danggui Buxue Decoction for 
      renal anemia when combined with western medicine treatment of anemia. METHODS: 
      Electronic searching Medline, Embase, Web of Science, Cochrane Library, Chinese 
      BioMedical Literature Database (CBM), China National Knowledge Infrastructure 
      (CNKI), WanFang data, Chinese Sci-tech periodical full-text database (VIP). 
      Randomized controlled trials reported results of efficacy and safety of Danggui 
      Buxue Decoction in combination with western medicine treatment of anemia for 
      renal anemia. The "risk of bias assessment tool (Version 5.1.0)" of Cochrane 
      Handbook was applied to assess the quality of included trials and RevMan 5.3 
      software was used for data analysis. RESULTS: A total of 111 studies was 
      retrieved, seven studies including 460 cases were included, the methodological 
      quality of included trials was poor. The result of meta-analysis demonstrated 
      that there was no difference in hemoglobin (Hb) [weighted mean differences (WMD) 
      =-8.75, 95% confidence interval (CI): (-18.64, 1.13), P=0.08], whereas the 
      subgroup analysis showed the difference was significant when the ratio of Radix 
      Astragali to Radix Angelicae Sinensis was 5:1 [WMD =-16.27, 95% CI: (-28.73, 
      -3.80), P=0.01], increase of Hb was more effective in experimental group than 
      control group and the difference was not significant when the ratio of Radix 
      Astragali to Radix Angelicae Sinensis was 5 not equal1 [WMD =-0.57, 95% CI: (-4.52, 3.39), 
      P=0.78]. There were significant differences in red blood cell (RBC) [WMD =-0.49, 
      95% CI: (-0.69, -0.28), P<0.00001], hematocrit (HCT) [WMD =-1.92, 95% CI: (-3.15, 
      -0.69), P=0.002] and clinical efficacy [odd ratio (OR) =0.30, 95% CI: (0.13, 
      0.69), P=0.004] between Danggui Buxue Decoction combination group and control 
      group, the experimental group was better than control group. There was no adverse 
      event reported in the experimental group. CONCLUSIONS: Danggui Buxue Decoction in 
      combination with conventional western medicine (CWM) for renal anemia might be 
      superior to CWM alone and there was no adverse event in the experimental group, 
      it might be more effective when the ratio of Radix Astragali to Radix Angelicae 
      Sinensis was 5:1. However, the quality of included studies was not high, and less 
      attention was paid to the safety, high quality randomized controlled trials are 
      needed to further confirm the findings.
FAU - Zhao, Ming-Ming
AU  - Zhao MM
AD  - Xiyuan Hospital, China Academy of Chinese Medical Sciences, Beijing 100091, 
      China.
FAU - Zhang, Yu
AU  - Zhang Y
AD  - Xiyuan Hospital, China Academy of Chinese Medical Sciences, Beijing 100091, 
      China.
FAU - Li, Liu-Sheng
AU  - Li LS
AD  - Xiyuan Hospital, China Academy of Chinese Medical Sciences, Beijing 100091, 
      China.
FAU - Yu, Zi-Kai
AU  - Yu ZK
AD  - Xiyuan Hospital, China Academy of Chinese Medical Sciences, Beijing 100091, 
      China.
FAU - Li, Bo
AU  - Li B
AD  - Beijing Hospital of Traditional Chinese Medicine, Capital Medical University, 
      Beijing Institute of Traditional Chinese Medicine, Beijing 100010, China.
LA  - eng
PT  - Journal Article
PL  - China
TA  - Ann Transl Med
JT  - Annals of translational medicine
JID - 101617978
PMC - PMC5395475
OTO - NOTNLM
OT  - Danggui Buxue Decoction
OT  - combine traditional Chinese and western medicine
OT  - meta-analysis
OT  - renal anemia
OT  - systematic review
COIS- Conflicts of Interest: The authors have no conflicts of interest to declare.
EDAT- 2017/05/04 06:00
MHDA- 2017/05/04 06:01
PMCR- 2017/03/01
CRDT- 2017/05/03 06:00
PHST- 2017/05/03 06:00 [entrez]
PHST- 2017/05/04 06:00 [pubmed]
PHST- 2017/05/04 06:01 [medline]
PHST- 2017/03/01 00:00 [pmc-release]
AID - atm-05-06-136 [pii]
AID - 10.21037/atm.2017.01.17 [doi]
PST - ppublish
SO  - Ann Transl Med. 2017 Mar;5(6):136. doi: 10.21037/atm.2017.01.17.