PMID- 28462600
OWN - NLM
STAT- MEDLINE
DCOM- 20180910
LR  - 20180910
IS  - 1476-4954 (Electronic)
IS  - 1476-4954 (Linking)
VI  - 31
IP  - 10
DP  - 2018 May
TI  - Symptomatic recovery and pharmacological management in a clinical cohort with 
      peripartum cardiomyopathy.
PG  - 1342-1349
LID - 10.1080/14767058.2017.1317341 [doi]
AB  - AIM: We aimed to characterize the clinical course with focus on pharmacological 
      management of peripartum cardiomyopathy (PPCM) in Sweden. METHODS: Twenty-four 
      consecutive patients were retrospectively identified among women presenting with 
      PPCM in Western Sweden. Of these, 14 had concomitant preeclampsia. There was only 
      one fatality. The mean (standard deviation) left ventricular ejection fraction 
      (LVEF) at diagnosis was 35.0 +/- 9.9%. Ten women, 47.6%, required intensive care 
      unit (ICU) admission. All patients received beta-blockers (BB) and 
      angiotensin-converting enzyme inhibitors/angiotensin II receptor blockers 
      (ACE-I/ARB), which were tapered off over a mean/median period of 3.3/2.5 years 
      with only one case of worsening heart failure. The mean follow-up for medication 
      was 7.9 +/- 2.6 years. Early and late/non-recovery was defined as New York Heart 
      Association (NYHA) functional class I and NYHA II-IV at one year, respectively. 
      Late recovery was associated with larger LVEDD at diagnosis (56.8 versus 62.4 mm) 
      was associated with late recovery, p = .02. RESULTS AND CONCLUSIONS: PPCM had an 
      overall good prognosis in this cohort. Left ventricular dilation at presentation 
      was a predictor of worse prognosis. Concurrent preeclampsia was common, but was 
      associated with better prognosis. Medication was safely discontinued in 75% of 
      patients.
FAU - Barasa, Anders
AU  - Barasa A
AD  - a Department of Molecular and Clinical Medicine , Institute of Medicine, 
      Sahlgrenska Academy, University of Gothenburg , Gothenburg , Sweden.
AD  - b Department of Medicine , Aga Khan University Hospital , Nairobi , Kenya.
FAU - Goloskokova, Valentina
AU  - Goloskokova V
AD  - a Department of Molecular and Clinical Medicine , Institute of Medicine, 
      Sahlgrenska Academy, University of Gothenburg , Gothenburg , Sweden.
FAU - Ladfors, Lars
AU  - Ladfors L
AD  - c Department of Obstetrics and Gynaecology , Sahlgrenska University 
      Hospital/Ostra , Gothenburg , Sweden.
FAU - Patel, Harshida
AU  - Patel H
AD  - d Faculty of Health and Care Sciences , Sahlgrenska Academy, University of 
      Gothenburg , Gothenburg , Sweden.
FAU - Schaufelberger, Maria
AU  - Schaufelberger M
AD  - a Department of Molecular and Clinical Medicine , Institute of Medicine, 
      Sahlgrenska Academy, University of Gothenburg , Gothenburg , Sweden.
LA  - eng
PT  - Journal Article
DEP - 20170502
PL  - England
TA  - J Matern Fetal Neonatal Med
JT  - The journal of maternal-fetal & neonatal medicine : the official journal of the 
      European Association of Perinatal Medicine, the Federation of Asia and Oceania 
      Perinatal Societies, the International Society of Perinatal Obstetricians
JID - 101136916
RN  - 0 (Adrenergic beta-Antagonists)
RN  - 0 (Angiotensin-Converting Enzyme Inhibitors)
SB  - IM
MH  - Adrenergic beta-Antagonists/*therapeutic use
MH  - Adult
MH  - Angiotensin-Converting Enzyme Inhibitors/*therapeutic use
MH  - Cardiomyopathies/diagnostic imaging/*drug therapy/physiopathology
MH  - Echocardiography
MH  - Female
MH  - Humans
MH  - Infant, Newborn
MH  - Intensive Care Units/statistics & numerical data
MH  - Pregnancy
MH  - Pregnancy Complications, Cardiovascular/diagnostic imaging/*drug 
      therapy/physiopathology
MH  - Pregnancy Outcome
MH  - Retrospective Studies
MH  - Statistics, Nonparametric
MH  - Ventricular Function, Left
OTO - NOTNLM
OT  - Cardiomyopathy
OT  - heart failure
OT  - pharmacological treatment
OT  - preeclampsia
OT  - pregnancy
EDAT- 2017/05/04 06:00
MHDA- 2018/09/11 06:00
CRDT- 2017/05/03 06:00
PHST- 2017/05/04 06:00 [pubmed]
PHST- 2018/09/11 06:00 [medline]
PHST- 2017/05/03 06:00 [entrez]
AID - 10.1080/14767058.2017.1317341 [doi]
PST - ppublish
SO  - J Matern Fetal Neonatal Med. 2018 May;31(10):1342-1349. doi: 
      10.1080/14767058.2017.1317341. Epub 2017 May 2.