PMID- 28462726
OWN - NLM
STAT- MEDLINE
DCOM- 20180423
LR  - 20231004
IS  - 1469-2198 (Electronic)
IS  - 0954-5794 (Print)
IS  - 0954-5794 (Linking)
VI  - 29
IP  - 4
DP  - 2017 Oct
TI  - Determinants of neonatal brain-derived neurotrophic factor and association with 
      child development.
PG  - 1499-1511
LID - 10.1017/S0954579417000414 [doi]
AB  - Using a population-based birth cohort in upstate New York (2008-2010), we 
      examined the determinants of brain-derived neurotrophic factor (BDNF) measured in 
      newborn dried blood spots (n = 2,637). We also examined the association between 
      neonatal BDNF and children's development. The cohort was initially designed to 
      examine the influence of infertility treatment on child development but found no 
      impact. Mothers rated children's development in five domains repeatedly through 
      age 3 years. Socioeconomic and maternal lifestyle determinants of BDNF were 
      examined using multivariable linear regression models. Generalized linear mixed 
      models estimated odds ratios for neonatal BDNF in relation to failing a 
      developmental domain. Smoking and drinking in pregnancy, nulliparity, non-White 
      ethnicity/race, and prepregnancy obesity were associated with lower neonatal 
      BDNF. Neonatal BDNF was not associated with failure for developmental domains; 
      however, there was an interaction between BDNF and preterm birth. In preterm 
      infants, a higher BDNF was associated with lower odds of failing any 
      developmental domains, after adjusting for confounders and infertility treatment. 
      This result was particularly significant for failure in communication. Our 
      findings suggest that BDNF levels in neonates may be impacted by maternal 
      lifestyle characteristics. More specifically, lower neonatal BDNF might be an 
      early marker of aberrant neurodevelopment in preterm infants.
FAU - Ghassabian, Akhgar
AU  - Ghassabian A
AD  - National Institutes of Health.
FAU - Sundaram, Rajeshwari
AU  - Sundaram R
AD  - National Institutes of Health.
FAU - Chahal, Nikhita
AU  - Chahal N
AD  - National Institutes of Health.
FAU - McLain, Alexander C
AU  - McLain AC
AD  - University of South Carolina.
FAU - Bell, Erin
AU  - Bell E
AD  - Albany School of Public Health.
FAU - Lawrence, David A
AU  - Lawrence DA
AD  - Albany School of Public Health.
FAU - Yeung, Edwina H
AU  - Yeung EH
AD  - National Institutes of Health.
LA  - eng
GR  - ZIA HD008826-07/ImNIH/Intramural NIH HHS/United States
GR  - HHSN267200700019C/HD/NICHD NIH HHS/United States
GR  - ZIA HD008826-09/ImNIH/Intramural NIH HHS/United States
GR  - ZIA HD008826-10/ImNIH/Intramural NIH HHS/United States
GR  - HHSN275201200005C/HD/NICHD NIH HHS/United States
GR  - ZIA HD008826-08/ImNIH/Intramural NIH HHS/United States
PT  - Journal Article
DEP - 20170502
PL  - United States
TA  - Dev Psychopathol
JT  - Development and psychopathology
JID - 8910645
RN  - 0 (Biomarkers)
RN  - 0 (Brain-Derived Neurotrophic Factor)
RN  - 7171WSG8A2 (BDNF protein, human)
SB  - IM
MH  - Biomarkers/blood
MH  - Brain-Derived Neurotrophic Factor/*blood
MH  - Child Development/*physiology
MH  - Child, Preschool
MH  - Cohort Studies
MH  - Female
MH  - Humans
MH  - Infant
MH  - Infant, Newborn
MH  - Infant, Premature
MH  - Male
MH  - Mothers
MH  - New York
MH  - Pregnancy
MH  - Smoking
PMC - PMC6201316
MID - NIHMS987053
EDAT- 2017/05/04 06:00
MHDA- 2018/04/24 06:00
PMCR- 2018/10/25
CRDT- 2017/05/03 06:00
PHST- 2017/05/04 06:00 [pubmed]
PHST- 2018/04/24 06:00 [medline]
PHST- 2017/05/03 06:00 [entrez]
PHST- 2018/10/25 00:00 [pmc-release]
AID - S0954579417000414 [pii]
AID - 10.1017/S0954579417000414 [doi]
PST - ppublish
SO  - Dev Psychopathol. 2017 Oct;29(4):1499-1511. doi: 10.1017/S0954579417000414. Epub 
      2017 May 2.