PMID- 28463008
OWN - NLM
STAT- MEDLINE
DCOM- 20180430
LR  - 20180907
IS  - 1543-8392 (Electronic)
IS  - 1543-8384 (Linking)
VI  - 14
IP  - 8
DP  - 2017 Aug 7
TI  - Polymeric Nanocarriers Based on Cyclodextrins for Drug Delivery: Host-Guest 
      Interaction as Stimuli Responsive Linker.
PG  - 2475-2486
LID - 10.1021/acs.molpharmaceut.7b00160 [doi]
AB  - Stimuli responsive polymers have been extensively studied as nanocarriers for 
      drug delivery systems (DDSs), especially those based on supramolecular 
      interactions. Cyclodextrin (CD) is one kind of widely applied host molecule, and 
      the host-guest interactions between CD and different counterparts can respond to 
      different stimuli and thus can be applied as responsive linkers for polymeric 
      DDSs. In this review, the polymeric nanocarriers based on the host-guest 
      interactions between CD and ferrocene, azobenzene, and benzimidazole as DDSs are 
      summarized, with redox, light, and pH sensitivity, respectively. The mechanisms 
      for the stimuli responsive ability of the linkers, the application of them for 
      construction of DDSs with different polymer structures, and the controlled 
      release behaviors have been focused. In addition, the outlook and challenge of 
      these systems are discussed.
FAU - Peng, Liao
AU  - Peng L
AD  - Key Lab of Organic Optoelectronics & Molecular Engineering, Department of 
      Chemistry, Tsinghua University , Beijing 100084, P. R. China.
FAU - Liu, Senyang
AU  - Liu S
AD  - Key Lab of Organic Optoelectronics & Molecular Engineering, Department of 
      Chemistry, Tsinghua University , Beijing 100084, P. R. China.
FAU - Feng, Anchao
AU  - Feng A
AD  - College of Materials Science and Engineering, Beijing University of Chemical 
      Technology , Beijing 100029, P. R. China.
FAU - Yuan, Jinying
AU  - Yuan J
AUID- ORCID: 0000-0002-1667-9252
AD  - Key Lab of Organic Optoelectronics & Molecular Engineering, Department of 
      Chemistry, Tsinghua University , Beijing 100084, P. R. China.
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20170530
PL  - United States
TA  - Mol Pharm
JT  - Molecular pharmaceutics
JID - 101197791
RN  - 0 (Cyclodextrins)
RN  - 0 (Polymers)
SB  - IM
MH  - Cyclodextrins/*chemistry
MH  - Drug Delivery Systems/*methods
MH  - Hydrogen-Ion Concentration
MH  - Light
MH  - Oxidation-Reduction
MH  - Polymers/*chemistry
OTO - NOTNLM
OT  - drug delivery systems
OT  - host-guest chemistry
OT  - polymer self-assembly
OT  - stimuli responsive polymers
OT  - supramolecular structures
EDAT- 2017/05/04 06:00
MHDA- 2018/05/01 06:00
CRDT- 2017/05/03 06:00
PHST- 2017/05/04 06:00 [pubmed]
PHST- 2018/05/01 06:00 [medline]
PHST- 2017/05/03 06:00 [entrez]
AID - 10.1021/acs.molpharmaceut.7b00160 [doi]
PST - ppublish
SO  - Mol Pharm. 2017 Aug 7;14(8):2475-2486. doi: 10.1021/acs.molpharmaceut.7b00160. 
      Epub 2017 May 30.