PMID- 28463029
OWN - NLM
STAT- MEDLINE
DCOM- 20180705
LR  - 20181202
IS  - 1439-7609 (Electronic)
IS  - 1439-7595 (Linking)
VI  - 28
IP  - 1
DP  - 2018 Jan
TI  - High rate of improvement in serum matrix metalloproteinase-3 levels at 4 weeks 
      predicts remission at 52 weeks in RA patients treated with adalimumab.
PG  - 119-125
LID - 10.1080/14397595.2017.1317320 [doi]
AB  - OBJECTIVE: This study aimed to determine whether serum matrix metalloproteinase-3 
      (MMP-3) levels can predict remission in rheumatoid arthritis (RA) patients 
      treated with adalimumab (ADA). METHODS: Subjects were 114 RA patients 
      continuously treated with ADA for 52 weeks. Predictive factors at baseline and 4 
      weeks after initiation of ADA therapy for the achievement of remission (28-point 
      count Disease Activity Score-CRP (DAS28-CRP) < 2.3) at 52 weeks were evaluated by 
      multivariate logistic regression analysis. RESULTS: DAS28-CRP at 4 weeks (odds 
      ratio (OR) 0.614, 95% confidence interval (CI) 0.382-0.988) and improvement in 
      serum MMP-3 levels at 4 weeks (OR 1.057, 95% CI 1.002-1.032) were independent 
      predictors of remission at 52 weeks. The best cut-off level of DAS28-CRP and 
      improvement in serum MMP-3 levels at 4 weeks for predicting remission at 52 weeks 
      was 3.73 (sensitivity: 90%, specificity: 50%, area under the receiver operating 
      characteristic curve (AUC): 62%) and 39.93% (sensitivity: 47%, specificity: 83%, 
      AUC: 64%), respectively. CONCLUSION: Our findings suggest that a high rate of 
      improvement in serum MMP-3 levels at 4 weeks after initiation of ADA therapy can 
      predict remission at 52 weeks in RA patients.
FAU - Hattori, Yosuke
AU  - Hattori Y
AD  - a Department of Orthopaedic Surgery and Rheumatology , National Hospital 
      Organization Nagoya Medical Center , Nagoya , Japan.
FAU - Kojima, Toshihisa
AU  - Kojima T
AD  - b Department of Orthopaedic Surgery , Nagoya University Graduate School of 
      Medicine , Nagoya , Japan.
FAU - Kaneko, Atsushi
AU  - Kaneko A
AD  - a Department of Orthopaedic Surgery and Rheumatology , National Hospital 
      Organization Nagoya Medical Center , Nagoya , Japan.
FAU - Kida, Daihei
AU  - Kida D
AD  - a Department of Orthopaedic Surgery and Rheumatology , National Hospital 
      Organization Nagoya Medical Center , Nagoya , Japan.
FAU - Hirano, Yuji
AU  - Hirano Y
AD  - c Department of Rheumatology , Toyohashi Municipal Hospital , Toyohashi , Japan.
FAU - Fujibayashi, Takayoshi
AU  - Fujibayashi T
AD  - d Department of Orthopaedic Surgery , Konan Kosei Hospital , Konan , Japan.
FAU - Yabe, Yuichiro
AU  - Yabe Y
AD  - e Department of Rheumatology , Japan Community Healthcare Organization Tokyo 
      Shinjuku Medical Center , Tokyo , Japan.
FAU - Oguchi, Takeshi
AU  - Oguchi T
AD  - f Department of Orthopaedic Surgery , Anjo Kosei Hospital , Anjo , Japan.
FAU - Kanayama, Yasuhide
AU  - Kanayama Y
AD  - g Department of Orthopedic Surgery and Rheumatology , Toyota Kosei Hospital , 
      Toyota , Japan.
FAU - Miyake, Hiroyuki
AU  - Miyake H
AD  - h Department of Orthopaedic Surgery , Ichinomiya Municipal Hospital , Ichinomiya 
      , Japan.
FAU - Kato, Takefumi
AU  - Kato T
AD  - i Kato Clinic , Okazaki , Japan.
FAU - Takagi, Hideki
AU  - Takagi H
AD  - j Department of Orthopaedic Surgery , Nagoya Central Hospital , Nagoya , Japan.
FAU - Hayashi, Masatoshi
AU  - Hayashi M
AD  - k Department of Rheumatology , Nagano Red Cross Hospital , Nagano , Japan.
FAU - Ito, Takayasu
AU  - Ito T
AD  - l Ito Seikeigeka , Nagoya , Japan.
FAU - Shioura, Tomone
AU  - Shioura T
AD  - m Shizuoka Kosei Hospital , Shizuoka , Japan.
FAU - Takahashi, Nobunori
AU  - Takahashi N
AD  - b Department of Orthopaedic Surgery , Nagoya University Graduate School of 
      Medicine , Nagoya , Japan.
FAU - Ishikawa, Hisato
AU  - Ishikawa H
AD  - n Department of Orthopaedic Surgery , Japanese Red Cross Nagoya Daiichi Hospital 
      , Nagoya , Japan.
FAU - Funahashi, Koji
AU  - Funahashi K
AD  - o Department of Orthopaedic Surgery , Kariya Toyota General Hospital , Kariya , 
      Japan.
FAU - Ishiguro, Naoki
AU  - Ishiguro N
AD  - b Department of Orthopaedic Surgery , Nagoya University Graduate School of 
      Medicine , Nagoya , Japan.
LA  - eng
PT  - Journal Article
DEP - 20170502
PL  - England
TA  - Mod Rheumatol
JT  - Modern rheumatology
JID - 100959226
RN  - 0 (Antirheumatic Agents)
RN  - 9007-41-4 (C-Reactive Protein)
RN  - EC 3.4.24.17 (MMP3 protein, human)
RN  - EC 3.4.24.17 (Matrix Metalloproteinase 3)
RN  - FYS6T7F842 (Adalimumab)
SB  - IM
MH  - Adalimumab/*therapeutic use
MH  - Adult
MH  - Aged
MH  - Antirheumatic Agents/*therapeutic use
MH  - Arthritis, Rheumatoid/blood/*drug therapy
MH  - C-Reactive Protein
MH  - Female
MH  - Humans
MH  - Male
MH  - Matrix Metalloproteinase 3/*blood
MH  - Middle Aged
MH  - Remission Induction
MH  - Time Factors
MH  - Treatment Outcome
OTO - NOTNLM
OT  - MMP-3
OT  - Rheumatoid arthritis
OT  - adalimumab
OT  - matrix metalloproteinase-3
OT  - remission
EDAT- 2017/05/04 06:00
MHDA- 2018/07/06 06:00
CRDT- 2017/05/03 06:00
PHST- 2017/05/04 06:00 [pubmed]
PHST- 2018/07/06 06:00 [medline]
PHST- 2017/05/03 06:00 [entrez]
AID - 10.1080/14397595.2017.1317320 [doi]
PST - ppublish
SO  - Mod Rheumatol. 2018 Jan;28(1):119-125. doi: 10.1080/14397595.2017.1317320. Epub 
      2017 May 2.