PMID- 28463748
OWN - NLM
STAT- MEDLINE
DCOM- 20180110
LR  - 20220409
IS  - 1872-7506 (Electronic)
IS  - 0925-4927 (Linking)
VI  - 264
DP  - 2017 Jun 30
TI  - Using short-range and long-range functional connectivity to identify 
      schizophrenia with a family-based case-control design.
PG  - 60-67
LID - S0925-4927(17)30002-1 [pii]
LID - 10.1016/j.pscychresns.2017.04.010 [doi]
AB  - Abnormal short-range and long-range functional connectivities (FCs) have been 
      implicated in the neurophysiology of schizophrenia. This study was conducted to 
      examine the potential of short-range and long-range FCs for differentiating the 
      patients from the controls with a family-based case-control design. Twenty-eight 
      first-episode, drug-naive patients with schizophrenia, 28 unaffected siblings of 
      the patients (family-based controls, FBCs), and 40 healthy controls (HCs) 
      underwent resting-state functional magnetic resonance imaging (fMRI) scans. The 
      data were analyzed by short-range and long-range FC analyses, receiver operating 
      characteristic curve (ROC) and support vector machine (SVM). Compared with the 
      FBCs/HCs, the patients exhibit increased short-range positive FC strength (spFCS) 
      and/or long-range positive FC strength (lpFCS) in the default-mode network (DMN) 
      and decreased spFCS and lpFCS in the sensorimotor circuits. Furthermore, a 
      combination of the spFCS values in the right superior parietal lobule and the 
      lpFCS values in the left fusiform gyrus/cerebellum VI can differentiate the 
      patients from the FBCs with high sensitivity and specificity. The findings 
      highlight the importance of the DMN and sensorimotor circuits in the pathogenesis 
      of schizophrenia. Combining with family-based case-control design may be a viable 
      option to limit the confounding effects of environmental risk factors in 
      neuroimaging studies of schizophrenia.
CI  - Copyright (c) 2017 Elsevier Ireland Ltd. All rights reserved.
FAU - Guo, Wenbin
AU  - Guo W
AD  - Department of Psychiatry of the Second Xiangya Hospital, Central South 
      University, Changsha, Hunan 410011, China; Mental Health Institute of the Second 
      Xiangya Hospital, Central South University, Changsha, Hunan, China; National 
      Clinical Research Center on Mental Disorders, Changsha, Hunan, China; National 
      Technology Institute on Mental Disorders, Changsha, Hunan, China; Hunan Key 
      Laboratory of Psychiatry and Mental Health, Changsha, Hunan, China. Electronic 
      address: guowenbin76@163.com.
FAU - Liu, Feng
AU  - Liu F
AD  - Key Laboratory for NeuroInformation of Ministry of Education, School of Life 
      Science and Technology, University of Electronic Science and Technology of China, 
      Chengdu, Sichuan, China.
FAU - Chen, Jindong
AU  - Chen J
AD  - Department of Psychiatry of the Second Xiangya Hospital, Central South 
      University, Changsha, Hunan 410011, China; Mental Health Institute of the Second 
      Xiangya Hospital, Central South University, Changsha, Hunan, China; National 
      Clinical Research Center on Mental Disorders, Changsha, Hunan, China; National 
      Technology Institute on Mental Disorders, Changsha, Hunan, China; Hunan Key 
      Laboratory of Psychiatry and Mental Health, Changsha, Hunan, China.
FAU - Wu, Renrong
AU  - Wu R
AD  - Department of Psychiatry of the Second Xiangya Hospital, Central South 
      University, Changsha, Hunan 410011, China; Mental Health Institute of the Second 
      Xiangya Hospital, Central South University, Changsha, Hunan, China; National 
      Clinical Research Center on Mental Disorders, Changsha, Hunan, China; National 
      Technology Institute on Mental Disorders, Changsha, Hunan, China; Hunan Key 
      Laboratory of Psychiatry and Mental Health, Changsha, Hunan, China.
FAU - Li, Lehua
AU  - Li L
AD  - Department of Psychiatry of the Second Xiangya Hospital, Central South 
      University, Changsha, Hunan 410011, China; Mental Health Institute of the Second 
      Xiangya Hospital, Central South University, Changsha, Hunan, China; National 
      Clinical Research Center on Mental Disorders, Changsha, Hunan, China; National 
      Technology Institute on Mental Disorders, Changsha, Hunan, China; Hunan Key 
      Laboratory of Psychiatry and Mental Health, Changsha, Hunan, China.
FAU - Zhang, Zhikun
AU  - Zhang Z
AD  - Mental Health Center of the First Affiliated Hospital, Guangxi Medical 
      University, Nanning, Guangxi, China.
FAU - Chen, Huafu
AU  - Chen H
AD  - Key Laboratory for NeuroInformation of Ministry of Education, School of Life 
      Science and Technology, University of Electronic Science and Technology of China, 
      Chengdu, Sichuan, China.
FAU - Zhao, Jingping
AU  - Zhao J
AD  - Department of Psychiatry of the Second Xiangya Hospital, Central South 
      University, Changsha, Hunan 410011, China; Mental Health Institute of the Second 
      Xiangya Hospital, Central South University, Changsha, Hunan, China; National 
      Clinical Research Center on Mental Disorders, Changsha, Hunan, China; National 
      Technology Institute on Mental Disorders, Changsha, Hunan, China; Hunan Key 
      Laboratory of Psychiatry and Mental Health, Changsha, Hunan, China. Electronic 
      address: zhaojingpingcsu@163.com.
LA  - eng
PT  - Journal Article
DEP - 20170424
PL  - Netherlands
TA  - Psychiatry Res Neuroimaging
JT  - Psychiatry research. Neuroimaging
JID - 101723001
SB  - IM
MH  - Adult
MH  - Case-Control Studies
MH  - Cerebellum/diagnostic imaging/physiopathology
MH  - Family/psychology
MH  - Female
MH  - Humans
MH  - Magnetic Resonance Imaging/*methods
MH  - Parietal Lobe/diagnostic imaging/physiopathology
MH  - Rest
MH  - Schizophrenia/*diagnostic imaging/physiopathology
MH  - *Schizophrenic Psychology
MH  - Siblings/*psychology
MH  - *Support Vector Machine
MH  - Temporal Lobe/diagnostic imaging/physiopathology
MH  - Young Adult
OTO - NOTNLM
OT  - Default-mode network
OT  - Family-based case-control design
OT  - Schizophrenia
OT  - Sensorimotor circuits
OT  - Short-range and long-range functional connectivities
EDAT- 2017/05/04 06:00
MHDA- 2018/01/11 06:00
CRDT- 2017/05/03 06:00
PHST- 2017/01/03 00:00 [received]
PHST- 2017/04/06 00:00 [revised]
PHST- 2017/04/22 00:00 [accepted]
PHST- 2017/05/04 06:00 [pubmed]
PHST- 2018/01/11 06:00 [medline]
PHST- 2017/05/03 06:00 [entrez]
AID - S0925-4927(17)30002-1 [pii]
AID - 10.1016/j.pscychresns.2017.04.010 [doi]
PST - ppublish
SO  - Psychiatry Res Neuroimaging. 2017 Jun 30;264:60-67. doi: 
      10.1016/j.pscychresns.2017.04.010. Epub 2017 Apr 24.