PMID- 28463901
OWN - NLM
STAT- MEDLINE
DCOM- 20180108
LR  - 20181025
IS  - 1530-0315 (Electronic)
IS  - 0195-9131 (Linking)
VI  - 49
IP  - 9
DP  - 2017 Sep
TI  - A Mechanism Underlying Preventive Effect of High-Intensity Training on Colon 
      Cancer.
PG  - 1805-1816
LID - 10.1249/MSS.0000000000001312 [doi]
AB  - INTRODUCTION: We examined effects of high-intensity training on chemically 
      induced aberrant crypt foci (ACF) in rat colon. We also investigated mechanisms 
      that may underlie the results obtained, with a focus on secreted protein acidic 
      and rich in cysteine (SPARC), which has been proposed as an exercise-related 
      factor of colon cancer prevention. METHODS: After an administration of 
      1,2-dimethylhydrazine, F344 rats executed high-intensity intermittent swimming 
      training (HIIST) (twelve 20-s swimming with a weight [16% body weight] with 10-s 
      pauses between the bouts) 5 d.wk for 4 wk. The acute and chronic effects of the 
      HIIST on SPARC were evaluated in rats. We evaluated the in vitro and in vivo 
      effects of 5' AMP-activated protein kinase (AMPK) activator on SPARC in rat serum 
      and epitrochlearis muscle. In human subjects, we determined serum SPARC after 
      exhaustive bicycling consisting of six to seven bouts of exercise at 170% V O2max 
      with 10-s rests between the bouts (high-intensity intermittent bicycling [HIIB]). 
      The SPARC mRNA in human vastus lateralis was measured before and after the HIIB 
      for 4 d.wk for 6 wk (HIIB-training [HIIBT]). RESULTS: The numbers of ACF were 
      lower in the HIIST (47 +/- 22) compared with the control (122 +/- 47) rats (P < 
      0.05). SPARC in epitrochlearis and serum after HIIS of the trained rat was higher 
      than that in the control resting rats. In vitro and vivo AMPK stimulation 
      increased mRNA and SPARC protein in rat epitrochlearis, respectively. The human 
      serum SPARC after the HIIB was elevated. SPARC mRNA in human muscle was elevated 
      after the HIIBT. CONCLUSIONS: The results demonstrated that HIIST inhibits 
      1,2-dimethylhydrazine-induced colon ACF development. This effect may be explained 
      by SPARC induction by the exercise intensity-related factor AMPK, potentially 
      explaining the preventive effects of high-intensity intermittent exercise 
      training against colon cancer.
FAU - Matsuo, Kaori
AU  - Matsuo K
AD  - 1Faculty of Sport and Health Science, Ritsumeikan University, Kusatsu, Shiga, 
      JAPAN; 2Faculty of Health and Sports Science, Juntendo University, Inzai, Chiba, 
      JAPAN; and 3Department of Food Science and Nutrition, The University of Shiga 
      Prefecture, Hikone, Shiga, JAPAN.
FAU - Sato, Koji
AU  - Sato K
FAU - Suemoto, Ken
AU  - Suemoto K
FAU - Miyamoto-Mikami, Eri
AU  - Miyamoto-Mikami E
FAU - Fuku, Noriyuki
AU  - Fuku N
FAU - Higashida, Kazuhiko
AU  - Higashida K
FAU - Tsuji, Katsunori
AU  - Tsuji K
FAU - Xu, Yuzhong
AU  - Xu Y
FAU - Liu, Xin
AU  - Liu X
FAU - Iemitsu, Motoyuki
AU  - Iemitsu M
FAU - Hamaoka, Takafumi
AU  - Hamaoka T
FAU - Tabata, Izumi
AU  - Tabata I
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PL  - United States
TA  - Med Sci Sports Exerc
JT  - Medicine and science in sports and exercise
JID - 8005433
RN  - 0 (Glucose Transporter Type 4)
RN  - 0 (Mitochondrial Proteins)
RN  - 0 (Osteonectin)
RN  - 0 (Peroxisome Proliferator-Activated Receptor Gamma Coactivator 1-alpha)
RN  - 0 (Ppargc1a protein, rat)
RN  - 0 (SPARC protein, human)
RN  - 0 (Slc2a4 protein, rat)
RN  - EC 2.7.11.31 (AMP-Activated Protein Kinases)
SB  - IM
MH  - AMP-Activated Protein Kinases/metabolism
MH  - Animals
MH  - Blotting, Western
MH  - Colon/pathology
MH  - Colonic Neoplasms/*prevention & control
MH  - Glucose Transporter Type 4/metabolism
MH  - *High-Intensity Interval Training
MH  - Humans
MH  - Male
MH  - Mitochondrial Proteins/metabolism
MH  - Models, Animal
MH  - Muscle, Skeletal/*metabolism
MH  - Osteonectin/metabolism
MH  - Oxidation-Reduction
MH  - Peroxisome Proliferator-Activated Receptor Gamma Coactivator 1-alpha/metabolism
MH  - Physical Conditioning, Animal/*physiology
MH  - Rats, Inbred F344
MH  - Swimming/physiology
MH  - Young Adult
EDAT- 2017/05/04 06:00
MHDA- 2018/01/09 06:00
CRDT- 2017/05/03 06:00
PHST- 2017/05/04 06:00 [pubmed]
PHST- 2018/01/09 06:00 [medline]
PHST- 2017/05/03 06:00 [entrez]
AID - 10.1249/MSS.0000000000001312 [doi]
PST - ppublish
SO  - Med Sci Sports Exerc. 2017 Sep;49(9):1805-1816. doi: 
      10.1249/MSS.0000000000001312.