PMID- 28464523
OWN - NLM
STAT- MEDLINE
DCOM- 20180723
LR  - 20211204
IS  - 1864-0648 (Electronic)
IS  - 1864-063X (Linking)
VI  - 10
IP  - 12
DP  - 2017 Dec
TI  - Low-level light emitting diode therapy promotes long-term functional recovery 
      after experimental stroke in mice.
PG  - 1761-1771
LID - 10.1002/jbio.201700038 [doi]
AB  - We aimed to investigate the effects of low-level light emitting diode therapy 
      (LED-T) on the long-term functional outcomes after cerebral ischemia, and the 
      optimal timing of LED-T initiation for achieving suitable functional recovery. 
      Focal cerebral ischemia was induced in mice via photothrombosis. These mice were 
      assigned to a sham-operated (control), ischemic (vehicle), or LED-T group 
      [initiation immediately (acute), 4 days (subacute) or 10 days (delayed) after 
      ischemia, followed by once-daily treatment for 7 days]. Behavioral outcomes were 
      assessed 21 and 28 days post-ischemia, and histopathological analysis was 
      performed 28 days post-ischemia. The acute and subacute LED-T groups showed a 
      significant improvement in motor function up to 28 days post-ischemia, although 
      no brain atrophy recovery was noted. We observed proliferating cells (BrdU(+) ) 
      in the ischemic brain, and significant increases in BrdU(+) /GFAP(+) , BrdU(+) 
      /DCX(+) , BrdU(+) /NeuN(+) , and CD31(+) cells in the subacute LED-T group. 
      However, the BrdU(+) /Iba-1(+) cell count was reduced in the subacute LED-T 
      group. Furthermore, the brain-derived neurotrophic factor (BDNF) was 
      significantly upregulated in the subacute LED-T group. We concluded that LED-T 
      administered during the subacute stage had a positive impact on the long-term 
      functional outcome, probably via neuron and astrocyte proliferation, blood vessel 
      reconstruction, and increased BDNF expression. Picture: The rotarod test for 
      motor coordination showed that acute and subacute LED-T improves long-term 
      functional recovery after cerebral ischemia.
CI  - (c) 2017 Wiley-VCH Verlag GmbH & Co. KGaA, Weinheim.
FAU - Lee, Hae In
AU  - Lee HI
AD  - Department of Rehabilitation Medicine, School of Medicine, Pusan National 
      University, Yangsan, Gyeongnam, 50612, Republic of Korea.
AD  - Research Institute for Convergence of Biomedical Science and Technology, Pusan 
      National University Yangsan Hospital, Yangsan, Gyeongnam, 50612, Republic of 
      Korea.
FAU - Lee, Sae-Won
AU  - Lee SW
AD  - Department of Korean Medical Science, School of Korean Medicine, Pusan National 
      University, Yangsan, Gyeongnam, 50612, Republic of Korea.
AD  - Graduate Training Program of Korean Medicine for Healthy-Aging, Pusan National 
      University, Yangsan, Gyeongnam, 50612, Republic of Korea.
AD  - Korean Medical Science Research Center for Healthy-Aging, Pusan National 
      University, Yangsan, Gyeongnam, 50612, Republic of Korea.
FAU - Kim, Nam Gyun
AU  - Kim NG
AD  - Medical Research Center of Color Seven, Seoul, 06719, Republic of Korea.
FAU - Park, Kyoung-Jun
AU  - Park KJ
AD  - Medical Research Center of Color Seven, Seoul, 06719, Republic of Korea.
FAU - Choi, Byung Tae
AU  - Choi BT
AD  - Department of Korean Medical Science, School of Korean Medicine, Pusan National 
      University, Yangsan, Gyeongnam, 50612, Republic of Korea.
AD  - Graduate Training Program of Korean Medicine for Healthy-Aging, Pusan National 
      University, Yangsan, Gyeongnam, 50612, Republic of Korea.
AD  - Korean Medical Science Research Center for Healthy-Aging, Pusan National 
      University, Yangsan, Gyeongnam, 50612, Republic of Korea.
FAU - Shin, Yong-Il
AU  - Shin YI
AD  - Department of Rehabilitation Medicine, School of Medicine, Pusan National 
      University, Yangsan, Gyeongnam, 50612, Republic of Korea.
AD  - Research Institute for Convergence of Biomedical Science and Technology, Pusan 
      National University Yangsan Hospital, Yangsan, Gyeongnam, 50612, Republic of 
      Korea.
FAU - Shin, Hwa Kyoung
AU  - Shin HK
AD  - Department of Korean Medical Science, School of Korean Medicine, Pusan National 
      University, Yangsan, Gyeongnam, 50612, Republic of Korea.
AD  - Graduate Training Program of Korean Medicine for Healthy-Aging, Pusan National 
      University, Yangsan, Gyeongnam, 50612, Republic of Korea.
AD  - Korean Medical Science Research Center for Healthy-Aging, Pusan National 
      University, Yangsan, Gyeongnam, 50612, Republic of Korea.
LA  - eng
PT  - Journal Article
DEP - 20170502
PL  - Germany
TA  - J Biophotonics
JT  - Journal of biophotonics
JID - 101318567
RN  - 0 (Brain-Derived Neurotrophic Factor)
RN  - 0 (Dcx protein, mouse)
RN  - 0 (Doublecortin Protein)
SB  - IM
MH  - Animals
MH  - Astrocytes/pathology/radiation effects
MH  - Brain Ischemia/metabolism/pathology/*physiopathology/*therapy
MH  - Brain-Derived Neurotrophic Factor/metabolism
MH  - Cell Differentiation/radiation effects
MH  - Cell Proliferation/radiation effects
MH  - Disease Models, Animal
MH  - Doublecortin Protein
MH  - Male
MH  - Mice
MH  - Mice, Inbred C57BL
MH  - Microglia/pathology/radiation effects
MH  - Neurons/pathology/radiation effects
MH  - Phototherapy/*instrumentation
MH  - Recovery of Function/*radiation effects
MH  - Stroke/*physiopathology/*therapy
MH  - Time Factors
OTO - NOTNLM
OT  - BDNF
OT  - Functional recovery
OT  - focal cerebral ischemia
OT  - neurotrophic factor
OT  - photostimulation
OT  - post-stroke
EDAT- 2017/05/04 06:00
MHDA- 2018/07/24 06:00
CRDT- 2017/05/03 06:00
PHST- 2017/02/14 00:00 [received]
PHST- 2017/03/06 00:00 [revised]
PHST- 2017/03/10 00:00 [accepted]
PHST- 2017/05/04 06:00 [pubmed]
PHST- 2018/07/24 06:00 [medline]
PHST- 2017/05/03 06:00 [entrez]
AID - 10.1002/jbio.201700038 [doi]
PST - ppublish
SO  - J Biophotonics. 2017 Dec;10(12):1761-1771. doi: 10.1002/jbio.201700038. Epub 2017 
      May 2.