PMID- 28465268
OWN - NLM
STAT- MEDLINE
DCOM- 20171002
LR  - 20171002
IS  - 1878-8769 (Electronic)
IS  - 1878-8750 (Linking)
VI  - 104
DP  - 2017 Aug
TI  - Intracranial Blood Flow Changes in Patients with High-Grade Severe Carotid Artery 
      Stenosis After Stenting.
PG  - 863-868
LID - S1878-8750(17)30652-6 [pii]
LID - 10.1016/j.wneu.2017.04.144 [doi]
AB  - OBJECTIVE: We investigated whether the cerebral hemodynamic changes of pre- and 
      poststenting in patients with severe carotid stenosis differ by stenosis grades. 
      METHODS: We prospectively recruited patients who underwent carotid artery 
      stenting (CAS) after acute ischemic stroke from June 2014 to December 2015. We 
      compared the mean relative cerebral blood flow (rCBF) changes (measured by 
      whole-brain computed tomography perfusion) pre- and poststenting in patients with 
      high-grade severe stenosis (HGSS) (90%-99%) versus patients with low-grade severe 
      stenosis (LGSS) (70%-89%). RESULTS: Among 24 patients included in the study (mean 
      age, 66.2 +/- 7.2 years; 91.7% men), 62.5% (15/24) were in the HGSS group and 37.5% 
      (9/24) were in the LGSS group. In the HGSS group, rCBF increased in territories 
      of the anterior cerebral artery (P = 0.021), middle cerebral artery (P < 0.001), 
      posterior cerebral artery (P = 0.001), and basil ganglia (P = 0.003) after 
      stenting. Of the patients with HGSS, 53.3% (8/15) had collateral flow through 
      anterior communicating artery (AcomA) prestenting. After stenting, all the AcomA 
      collaterals in HGSS reverted to normal (P = 0.002). CONCLUSIONS: The improvement 
      of brain perfusion combined with the normalization of collateral flow through the 
      circle of Willis after CAS was observed only in patients with HGSS.
CI  - Copyright (c) 2017 Elsevier Inc. All rights reserved.
FAU - Huang, Lei
AU  - Huang L
AD  - Department of Radiology, Huashan Hospital, Fudan University, Shanghai, China.
FAU - Cao, Wenjie
AU  - Cao W
AD  - Department of Neurology, Huashan Hospital, Fudan University, Shanghai, China.
FAU - Ge, Liang
AU  - Ge L
AD  - Department of Radiology, Huashan Hospital, Fudan University, Shanghai, China.
FAU - Lu, Gang
AU  - Lu G
AD  - Department of Radiology, Huashan Hospital, Fudan University, Shanghai, China.
FAU - Zhang, Xiaolong
AU  - Zhang X
AD  - Department of Radiology, Huashan Hospital, Fudan University, Shanghai, China.
FAU - Geng, Daoying
AU  - Geng D
AD  - Department of Radiology, Huashan Hospital, Fudan University, Shanghai, China. 
      Electronic address: hsyygdy@163.com.
LA  - eng
PT  - Case Reports
PT  - Journal Article
DEP - 20170502
PL  - United States
TA  - World Neurosurg
JT  - World neurosurgery
JID - 101528275
SB  - IM
MH  - Aged
MH  - Blood Flow Velocity/physiology
MH  - Blood Volume/physiology
MH  - Brain/*blood supply
MH  - Carotid Stenosis/classification/complications/diagnostic imaging/*therapy
MH  - Cerebral Infarction/classification/diagnostic imaging/etiology/*therapy
MH  - Collateral Circulation/physiology
MH  - Computed Tomography Angiography
MH  - Female
MH  - Hemodynamics/*physiology
MH  - Humans
MH  - Male
MH  - Middle Aged
MH  - Prospective Studies
MH  - Regional Blood Flow/physiology
MH  - *Stents
OTO - NOTNLM
OT  - CT perfusion
OT  - Carotid artery stenting
OT  - Circle of Willis
OT  - High-grade stenosis
EDAT- 2017/05/04 06:00
MHDA- 2017/10/03 06:00
CRDT- 2017/05/04 06:00
PHST- 2016/12/26 00:00 [received]
PHST- 2017/04/21 00:00 [revised]
PHST- 2017/04/22 00:00 [accepted]
PHST- 2017/05/04 06:00 [pubmed]
PHST- 2017/10/03 06:00 [medline]
PHST- 2017/05/04 06:00 [entrez]
AID - S1878-8750(17)30652-6 [pii]
AID - 10.1016/j.wneu.2017.04.144 [doi]
PST - ppublish
SO  - World Neurosurg. 2017 Aug;104:863-868. doi: 10.1016/j.wneu.2017.04.144. Epub 2017 
      May 2.