PMID- 28466560
OWN - NLM
STAT- MEDLINE
DCOM- 20170621
LR  - 20190816
IS  - 1099-0844 (Electronic)
IS  - 0263-6484 (Linking)
VI  - 35
IP  - 4
DP  - 2017 Jun
TI  - Bisphenol A triggers proliferation and migration of laryngeal squamous cell 
      carcinoma via GPER mediated upregulation of IL-6.
PG  - 209-216
LID - 10.1002/cbf.3265 [doi]
AB  - Bisphenol A (BPA) can be accumulated into the human body via food intake and 
      inhalation. Numerous studies indicated that BPA can trigger the tumorigenesis and 
      progression of cancer cells. Laryngeal cancer cells can be exposed to BPA 
      directly via food digestion, while there were very limited data concerning the 
      effect of BPA on the development of laryngeal squamous cell carcinoma (LSCC). Our 
      present study revealed that nanomolar BPA can trigger the proliferation of LSCC 
      cells. Bisphenol A also increased the in vitro migration and invasion of LSCC 
      cells and upregulated the expression of matrix metallopeptidase 2. Among various 
      chemokines tested, the expression of IL-6 was significantly increased in LSCC 
      cells treated with BPA for 24 hours. Neutralization antibody of IL-6 or si-IL-6 
      can attenuate BPA-induced proliferation and migration of LSCC cells. Targeted 
      inhibition of G protein-coupled estrogen receptor, while not estrogen receptor 
      (ERalpha), abolished BPA-induced IL-6 expression, proliferation, and migration of 
      LSCC cells. The increased IL-6 can further activate its downstream signal 
      molecule STAT3, which was evidenced by the results of increased phosphorylation 
      and nuclear translocation of STAT3, while si-IL-6 and si-GPER can both reverse 
      BPA-induced activation of STAT3. Collectively, our present study revealed that 
      BPA can trigger the progression of LSCC via GPER-mediated upregulation of IL-6. 
      Therefore, more attention should be paid for the BPA exposure on the development 
      of laryngeal cancer.
CI  - Copyright (c) 2017 John Wiley & Sons, Ltd.
FAU - Li, Shisheng
AU  - Li S
AD  - Department of Otolaryngology, Head and Neck Surgery, the Second Xiangya Hospital, 
      Central South University, Changsha, Hunan, PR China.
FAU - Wang, Bin
AU  - Wang B
AD  - Department of Otolaryngology, Head and Neck Surgery, the Second Xiangya Hospital, 
      Central South University, Changsha, Hunan, PR China.
FAU - Tang, Qinglai
AU  - Tang Q
AUID- ORCID: 0000-0001-5360-3161
AD  - Department of Otolaryngology, Head and Neck Surgery, the Second Xiangya Hospital, 
      Central South University, Changsha, Hunan, PR China.
FAU - Liu, Jiajia
AU  - Liu J
AD  - Department of Otolaryngology, Head and Neck Surgery, the Second Xiangya Hospital, 
      Central South University, Changsha, Hunan, PR China.
FAU - Yang, Xinming
AU  - Yang X
AD  - Department of Otolaryngology, Head and Neck Surgery, the Second Xiangya Hospital, 
      Central South University, Changsha, Hunan, PR China.
LA  - eng
PT  - Journal Article
DEP - 20170502
PL  - England
TA  - Cell Biochem Funct
JT  - Cell biochemistry and function
JID - 8305874
RN  - 0 (Benzhydryl Compounds)
RN  - 0 (GPER1 protein, human)
RN  - 0 (IL6 protein, human)
RN  - 0 (Interleukin-6)
RN  - 0 (Neoplasm Proteins)
RN  - 0 (Phenols)
RN  - 0 (Receptors, Estrogen)
RN  - 0 (Receptors, G-Protein-Coupled)
RN  - MLT3645I99 (bisphenol A)
SB  - IM
MH  - Benzhydryl Compounds/*pharmacology
MH  - Carcinoma, Squamous Cell/genetics/*metabolism/pathology
MH  - Cell Movement/*drug effects
MH  - Cell Proliferation/*drug effects
MH  - Gene Expression Regulation, Neoplastic
MH  - Hep G2 Cells
MH  - Humans
MH  - Interleukin-6/*biosynthesis/genetics
MH  - Laryngeal Neoplasms/genetics/*metabolism/pathology
MH  - Neoplasm Proteins/genetics/*metabolism
MH  - Phenols/*pharmacology
MH  - Receptors, Estrogen/genetics/*metabolism
MH  - Receptors, G-Protein-Coupled/genetics/*metabolism
MH  - Up-Regulation/*drug effects
OTO - NOTNLM
OT  - BPA
OT  - GPER
OT  - IL-6
OT  - LSCC
OT  - STAT3
EDAT- 2017/05/04 06:00
MHDA- 2017/06/22 06:00
CRDT- 2017/05/04 06:00
PHST- 2016/12/31 00:00 [received]
PHST- 2017/03/13 00:00 [revised]
PHST- 2017/03/14 00:00 [accepted]
PHST- 2017/05/04 06:00 [pubmed]
PHST- 2017/06/22 06:00 [medline]
PHST- 2017/05/04 06:00 [entrez]
AID - 10.1002/cbf.3265 [doi]
PST - ppublish
SO  - Cell Biochem Funct. 2017 Jun;35(4):209-216. doi: 10.1002/cbf.3265. Epub 2017 May 
      2.