PMID- 2846721
OWN - NLM
STAT- MEDLINE
DCOM- 19881220
LR  - 20191029
IS  - 8756-3320 (Print)
IS  - 8756-3320 (Linking)
VI  - 3
IP  - 1
DP  - 1987 Spring
TI  - Lack of efficacy of adenosine-5'-monophosphate against HSV-1 ocular shedding in 
      rabbits.
PG  - 31-8
AB  - Adenosine-5'-monophosphate (AMP) was evaluated for efficacy in the prevention of 
      spontaneous and induced herpes simplex virus type 1 (HSV-1) ocular shedding in 
      latently infected rabbits with strain McKrae. Intraperitoneal injections (IP) of 
      AMP (100 mg/kg) or NaCl (10 mg/kg) were given on postinoculation (PI) days 16-39. 
      Spontaneous viral shedding was monitored by ocular tear film swabs on PI days 
      20-39. In the induced rabbits, one group received AMP (IP) and a second group 
      received NaCl (IP) on PI days 66-77. In a third group, AMP (100 mg/kg) was given 
      twice a day IP on PI days 66-77, and AMP was applied by iontophoresis to these 
      eyes on PI days 68-74. In these three groups, ocular viral shedding was induced 
      by ocular iontophoresis of 6-hydroxydopamine on PI day 70 followed by topical 
      application of epinephrine for 5 days (PI days 70-74). HSV-1 ocular shedding was 
      monitored on PI days 66-78. There were no significant differences in spontaneous 
      or induced shedding patterns between the AMP (systemic or systemic plus ocular 
      iontophoresis) and the NaCl groups. These results suggest that this dose of 
      systemically administered AMP plus iontophoresis of AMP does not reduce ocular 
      HSV-1 shedding in rabbits.
FAU - Hill, J M
AU  - Hill JM
AD  - Lions Eye Research Laboratories, Louisiana State University Medical Center, 
      School of Medicine, New Orleans.
FAU - Haruta, Y
AU  - Haruta Y
FAU - Yamamoto, Y
AU  - Yamamoto Y
FAU - Jones, M D
AU  - Jones MD
FAU - Wingate, H L
AU  - Wingate HL
FAU - Jemison, M T
AU  - Jemison MT
LA  - eng
GR  - EY02377/EY/NEI NIH HHS/United States
GR  - EY06311/EY/NEI NIH HHS/United States
PT  - Comparative Study
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PT  - Research Support, U.S. Gov't, P.H.S.
PL  - United States
TA  - J Ocul Pharmacol
JT  - Journal of ocular pharmacology
JID - 8511297
RN  - 0 (Hydroxydopamines)
RN  - 415SHH325A (Adenosine Monophosphate)
RN  - 451W47IQ8X (Sodium Chloride)
RN  - 8HW4YBZ748 (Oxidopamine)
SB  - IM
MH  - Adenosine Monophosphate/*pharmacology
MH  - Animals
MH  - Eye/*microbiology
MH  - Hydroxydopamines/pharmacology
MH  - Injections, Intraperitoneal
MH  - Iontophoresis
MH  - Oxidopamine
MH  - Rabbits
MH  - Simplexvirus/immunology/*isolation & purification
MH  - Sodium Chloride/pharmacology
MH  - Tears/microbiology
EDAT- 1987/01/01 00:00
MHDA- 1987/01/01 00:01
CRDT- 1987/01/01 00:00
PHST- 1987/01/01 00:00 [pubmed]
PHST- 1987/01/01 00:01 [medline]
PHST- 1987/01/01 00:00 [entrez]
AID - 10.1089/jop.1987.3.31 [doi]
PST - ppublish
SO  - J Ocul Pharmacol. 1987 Spring;3(1):31-8. doi: 10.1089/jop.1987.3.31.