PMID- 28467955
OWN - NLM
STAT- MEDLINE
DCOM- 20190416
LR  - 20220311
IS  - 1419-8711 (Print)
IS  - 1419-8711 (Linking)
VI  - 19
IP  - 1
DP  - 2017 Mar
TI  - The impact of currently recommended antihypertensive therapy on depression and 
      other psychometric parameters: preliminary communication.
PG  - 11-22
AB  - AIMS: Current evidence on the psychological effects of antihypertensive 
      medications is controversial. The aim of this study was to evaluate the effect of 
      current antihypertensive medication on different psychometric parameters and on 
      serum brain-derived neurotrophic factor (BDNF) level. METHODS: Psychometric, 
      haemodynamic, arterial stiffness and laboratory parameters were evaluated before 
      and 3 months after the initiation of antihypertensive medication in untreated 
      hypertensive patients (HT, n=31), and once in healthy controls (CONT, n=22). 
      Subjects completed the following psychometric tests: Beck Depression Inventory 
      (BDI), Hamilton Anxiety Scale (HAM-A), Symptom Checklist 90 Revised (SCL-90), 
      Temperament Evaluation of Memphis, Pisa, Paris, and San Diego Autoquestionnaire, 
      Big Five Inventory, Pain Vigilance and Awareness Questionnaire and Berkeley 
      Expressivity Questionnaire. Amlodipine and/or perindopril compounds were 
      preferred medications. Serum BDNF was measured with ELISA. RESULTS: Brachial 
      systolic blood pressure, as well as pulse wave velocity were significantly 
      improved in the HT group over the 3-month follow-up (153.3+/-15.9 mmHg vs. 
      129.5+/-10.0 mmHg and 8.2+/-1.4 m/s vs 7.5+/-1.6 m/s, respectively). Similarly, we 
      found improvements in BDI (0.73 points) and in several Scl-90 subscales. Serum 
      BDNF was not different between CONT and HT and did not change for therapy. 
      CONCLUSIONS: Our results indicate that initiation of currently recommended 
      antihypertensive medications in newly diagnosed patients may have a significant 
      impact on psychological well-being of patients and could influence quality of 
      life as well.
FAU - Korosi, Beata
AU  - Korosi B
AD  - Department of Family Medicine, Semmelweis University, Budapest, Hungary. 
      janos.nemcsik@gmail.com.
FAU - Laszlo, Andrea
AU  - Laszlo A
FAU - Tabak, Adam
AU  - Tabak A
FAU - Batta, Dora
AU  - Batta D
FAU - Lenart, Lilla
AU  - Lenart L
FAU - Fekete, Andrea
AU  - Fekete A
FAU - Eorsi, Daniel
AU  - Eorsi D
FAU - Cseprekal, Orsolya
AU  - Cseprekal O
FAU - Tisler, Andras
AU  - Tisler A
FAU - Nemcsik-Bencze, Zsofia
AU  - Nemcsik-Bencze Z
FAU - Gonda, Xenia
AU  - Gonda X
FAU - Rihmer, Zoltan
AU  - Rihmer Z
FAU - Nemcsik, Janos
AU  - Nemcsik J
LA  - eng
PT  - Journal Article
PL  - Hungary
TA  - Neuropsychopharmacol Hung
JT  - Neuropsychopharmacologia Hungarica : a Magyar Pszichofarmakologiai Egyesulet 
      lapja = official journal of the Hungarian Association of Psychopharmacology
JID - 100961631
RN  - 0 (Antihypertensive Agents)
SB  - IM
MH  - Antihypertensive Agents
MH  - *Depression
MH  - Humans
MH  - Hypertension
MH  - *Psychometrics
MH  - Pulse Wave Analysis
MH  - Quality of Life
EDAT- 2017/05/04 06:00
MHDA- 2019/04/17 06:00
CRDT- 2017/05/04 06:00
PHST- 2017/05/04 06:00 [entrez]
PHST- 2017/05/04 06:00 [pubmed]
PHST- 2019/04/17 06:00 [medline]
PST - ppublish
SO  - Neuropsychopharmacol Hung. 2017 Mar;19(1):11-22.