PMID- 28468664
OWN - NLM
STAT- MEDLINE
DCOM- 20171102
LR  - 20181113
IS  - 1751-0147 (Electronic)
IS  - 0044-605X (Print)
IS  - 0044-605X (Linking)
VI  - 59
IP  - 1
DP  - 2017 May 3
TI  - Twenty-four-hour ambulatory electrocardiography characterization of heart rhythm 
      in Vipera berus-envenomed dogs.
PG  - 28
LID - 10.1186/s13028-017-0296-x [doi]
LID - 28
AB  - BACKGROUND: Vipera berus has a worldwide distribution and causes high morbidity 
      in dogs annually. A complication to envenomation may be cardiac arrhythmias. The 
      purpose of this study was to investigate the prevalence, types, and timing of 
      arrhythmias, using 24-h ambulatory electrocardiography (24-AECG), in dogs bitten 
      by V. berus in the first 24-32 h after envenomation. In addition, this study 
      aimed to investigate if there were differences in selected clinical and 
      hematological- and biochemical variables (including cardiac troponin I) at 
      admission between V. berus-envenomed dogs with and without detected pathologic 
      arrhythmias. Seventeen prospectively recruited client-owned dogs acutely 
      envenomed by V. berus, were therefore examined clinically and 
      echocardiographically, sampled for blood, hospitalized, and monitored by 24-AECG. 
      RESULTS: Clinically significant pathologic arrhythmias in this study were of 
      ventricular origin, such as frequent single ventricular premature contractions 
      (VPCs) and couplets of VPCs, episodes of ventricular tachycardia and 
      idioventricular rhythm, and "R-on-T phenomenon". Variations of these arrhythmias 
      were detected by 24-AECG in eight (47%) of included dogs. No arrhythmias were 
      detected by cardiac auscultation. Twenty-four hours following envenomation, four 
      out of eight dogs experienced decreases (all P < 0.039), and three out of eight 
      dogs experienced increases (all P < 0.034), in arrhythmic episodes. All four dogs 
      bitten on a limb developed pathologic arrhythmias. Otherwise, no significant 
      differences in clinical, hematological or biochemical variables were seen between 
      dogs with pathologic arrhythmias and those without. CONCLUSION: Forty-seven 
      percent of dogs bitten by V. berus included in this study experienced pathologic 
      arrhythmias of abnormal ventricular depolarization. During the first 24-32 h from 
      the snakebite, some dogs experienced a decrease in arrhythmic episodes and others 
      an increase in arrhythmic episodes. These findings indicate a potential value of 
      repeated or prolonged electrocardiography monitoring of envenomed dogs for 
      identification of which dogs that might benefit the most from prolonged 
      hospitalization for optimal monitoring and treatment of cardiac abnormalities. In 
      the present study, dogs that developed arrhythmias could not be differentiated 
      from dogs that did not based on clinical findings or hematological or biochemical 
      variables obtained at admission.
FAU - Vestberg, Anna Rave
AU  - Vestberg AR
AD  - Anicura Regional Animal Hospital, Ljusnevagen 17, 12848, Bagarmossen, Sweden. 
      anna.vestberg@anicura.se.
FAU - Tidholm, Anna
AU  - Tidholm A
AD  - Anicura Albano Animal Hospital, Rinkebyvagen 21a, 18236, Danderyd, Sweden.
AD  - Department of Clinical Sciences, Faculty of Veterinary Medicine and Small Animal 
      Sciences, Swedish University of Agricultural Sciences, P.O. Box 7084, 75007, 
      Uppsala, Sweden.
FAU - Ljungvall, Ingrid
AU  - Ljungvall I
AD  - Department of Clinical Sciences, Faculty of Veterinary Medicine and Small Animal 
      Sciences, Swedish University of Agricultural Sciences, P.O. Box 7084, 75007, 
      Uppsala, Sweden.
LA  - eng
PT  - Journal Article
DEP - 20170503
PL  - England
TA  - Acta Vet Scand
JT  - Acta veterinaria Scandinavica
JID - 0370400
RN  - 0 (Viper Venoms)
SB  - IM
MH  - Animals
MH  - Arrhythmias, Cardiac/etiology/pathology/*veterinary
MH  - Dog Diseases/*etiology/pathology
MH  - Dogs
MH  - Electrocardiography, Ambulatory/*veterinary
MH  - Female
MH  - Male
MH  - Snake Bites/*veterinary
MH  - Viper Venoms/*toxicity
MH  - Viperidae/*physiology
PMC - PMC5415709
OTO - NOTNLM
OT  - Ambulatory ECG
OT  - Arrhythmia
OT  - Dog
OT  - ECG
OT  - Snakebite
OT  - Vipera berus
EDAT- 2017/05/05 06:00
MHDA- 2017/11/03 06:00
PMCR- 2017/05/03
CRDT- 2017/05/05 06:00
PHST- 2017/02/27 00:00 [received]
PHST- 2017/04/28 00:00 [accepted]
PHST- 2017/05/05 06:00 [entrez]
PHST- 2017/05/05 06:00 [pubmed]
PHST- 2017/11/03 06:00 [medline]
PHST- 2017/05/03 00:00 [pmc-release]
AID - 10.1186/s13028-017-0296-x [pii]
AID - 296 [pii]
AID - 10.1186/s13028-017-0296-x [doi]
PST - epublish
SO  - Acta Vet Scand. 2017 May 3;59(1):28. doi: 10.1186/s13028-017-0296-x.