PMID- 28469100
OWN - NLM
STAT- MEDLINE
DCOM- 20180226
LR  - 20221207
IS  - 2542-5641 (Electronic)
IS  - 0366-6999 (Print)
IS  - 0366-6999 (Linking)
VI  - 130
IP  - 9
DP  - 2017 May 5
TI  - Relationship between Modulator Recognition Factor 2/AT-rich Interaction Domain 5B 
      Gene Variations and Type 2 Diabetes Mellitus or Lipid Metabolism in a Northern 
      Chinese Population.
PG  - 1055-1061
LID - 10.4103/0366-6999.204926 [doi]
AB  - BACKGROUND: Four single nucleotide polymorphisms (SNPs) in the modulator 
      recognition factor 2/AT-rich interaction domain 5B (MRF2/ARID5B) gene located at 
      chromosome 10q21.2 have been shown to be associated with both type 2 diabetes 
      mellitus (T2DM) and coronary artery disease in a Japanese cohort. This study 
      aimed to investigate the relationship between these SNPs (rs2893880, rs10740055, 
      rs7087507, rs10761600) and new-onset T2DM and lipid metabolism in a Northern 
      Chinese population. METHODS: This was a case-control study. The rs2893880, 
      rs10740055, rs7087507, and rs10761600 genetic variants were genotyped by SNPscan 
      and analyzed in relation to T2DM susceptibility in 2000 individuals (999 with 
      newly diagnosed T2DM and 1001 controls without diabetes mellitus). Associations 
      between the MRF2/ARID5B genetic models and T2DM were determined by multivariate 
      logistic regression. RESULTS: Regarding the rs10740055 SNP, AA was associated 
      with a higher risk of T2DM compared with codominant-type CC (adjusted by sex, 
      age, and body mass index [BMI], P= 0.041, odds ratio [OR] = 1.421, 95% confidence 
      interval [CI] 1.014-1.991). Meanwhile, AA individuals were at increased risk of 
      presenting with T2DM compared with individuals with CC or a single C (adjusted by 
      sex, age, and BMI, P= 0.034, OR = 1.366, 95% CI 1.023-1.824). With respect to 
      rs10761600, AT contributed to a higher risk of T2DM compared with AA (adjusted by 
      sex, age, and BMI, P= 0.013, OR = 1.585, 95% CI 1.101-2.282), while TT also 
      increased the risk of presenting with T2DM compared with AA or A (adjusted by 
      sex, age, and BMI, P= 0.004, OR = 1.632, 95% CI 1.166-2.284). High-density 
      lipoprotein cholesterol (HDL-C) levels were significantly different among the 
      three genotypes of rs7087507 in the controls (P = 0.048) (GG>GA). CONCLUSIONS: 
      The present results identified MRF2/ARID5B as a potential susceptibility gene for 
      new-onset T2DM in a Northern Chinese population, while the rs7087507 SNP was 
      associated with HDL-C levels. Further larger studies are required to validate 
      these findings.
FAU - Sun, Lu-Lu
AU  - Sun LL
AD  - Department of Endocrinology, The Second Affiliated Hospital of Harbin Medical 
      University, Harbin, Heilongjiang 150000, China.
FAU - Zhang, Si-Jia
AU  - Zhang SJ
AD  - Department of Endocrinology, The Second Affiliated Hospital of Harbin Medical 
      University, Harbin, Heilongjiang 150000, China.
FAU - Chen, Mei-Jun
AU  - Chen MJ
AD  - Department of Endocrinology, The Second Affiliated Hospital of Harbin Medical 
      University, Harbin, Heilongjiang 150000, China.
FAU - Elena, Kazakova
AU  - Elena K
AD  - Department of Endocrinology, The Second Affiliated Hospital of Harbin Medical 
      University, Harbin, Heilongjiang 150000, China.
FAU - Qiao, Hong
AU  - Qiao H
AD  - Department of Endocrinology, The Second Affiliated Hospital of Harbin Medical 
      University, Harbin, Heilongjiang 150000, China.
LA  - eng
PT  - Journal Article
PL  - China
TA  - Chin Med J (Engl)
JT  - Chinese medical journal
JID - 7513795
RN  - 0 (ARID5B protein, human)
RN  - 0 (DNA-Binding Proteins)
RN  - 0 (Transcription Factors)
SB  - IM
MH  - Asian People
MH  - Case-Control Studies
MH  - DNA-Binding Proteins/chemistry/*genetics/*metabolism
MH  - Diabetes Mellitus, Type 2/genetics/metabolism
MH  - Genetic Association Studies
MH  - Genetic Predisposition to Disease/genetics
MH  - Genotype
MH  - Humans
MH  - Lipid Metabolism/genetics/physiology
MH  - Odds Ratio
MH  - Polymorphism, Single Nucleotide/*genetics
MH  - Transcription Factors/chemistry/*genetics/*metabolism
PMC - PMC5421175
COIS- There are no conflicts of interest.
EDAT- 2017/05/05 06:00
MHDA- 2018/02/27 06:00
PMCR- 2017/05/05
CRDT- 2017/05/05 06:00
PHST- 2017/05/05 06:00 [entrez]
PHST- 2017/05/05 06:00 [pubmed]
PHST- 2018/02/27 06:00 [medline]
PHST- 2017/05/05 00:00 [pmc-release]
AID - ChinMedJ_2017_130_9_1055_204926 [pii]
AID - CMJ-130-1055 [pii]
AID - 10.4103/0366-6999.204926 [doi]
PST - ppublish
SO  - Chin Med J (Engl). 2017 May 5;130(9):1055-1061. doi: 10.4103/0366-6999.204926.