PMID- 28471413
OWN - NLM
STAT- PubMed-not-MEDLINE
LR  - 20201001
IS  - 2077-0383 (Print)
IS  - 2077-0383 (Electronic)
IS  - 2077-0383 (Linking)
VI  - 6
IP  - 5
DP  - 2017 May 4
TI  - Role of Autoantibodies in the Diagnosis of Connective-Tissue Disease ILD 
      (CTD-ILD) and Interstitial Pneumonia with Autoimmune Features (IPAF).
LID - 10.3390/jcm6050051 [doi]
LID - 51
AB  - The diagnosis of interstitial lung disease (ILD) requires meticulous evaluation 
      for an underlying connective tissue disease (CTD), with major implications for 
      prognosis and management. CTD associated ILD (CTD-ILD) occurs most commonly in 
      the context of an established CTD, but can be the first and/or only manifestation 
      of an occult CTD or occur in patients who have features suggestive of an 
      autoimmune process, but not meeting diagnostic criteria for a defined 
      CTD-recently defined as "interstitial pneumonia with autoimmune features" (IPAF). 
      The detection of specific autoantibodies serves a critical role in the diagnosis 
      of CTD-ILD, but there remains a lack of data to guide clinical practice including 
      which autoantibodies should be tested on initial assessment and when or in whom 
      serial testing should be performed. The implications of detecting autoantibodies 
      in patients with IPAF on disease behaviour and management remain unknown. The 
      evaluation of CTD-ILD is challenging due to the heterogeneity of presentations 
      and types of CTD and ILD that may be encountered, and thus it is imperative that 
      immunologic tests are interpreted in conjunction with a detailed rheumatologic 
      history and examination and multidisciplinary collaboration between respiratory 
      physicians, rheumatologists, immunologists, radiologists and pathologists.
FAU - Jee, Adelle S
AU  - Jee AS
AD  - Department of Respiratory and Sleep Medicine, Royal Prince Alfred Hospital, 
      Sydney, NSW 2050, Australia. adelle.jee@sswahs.nsw.gov.au.
AD  - Sydney Medical School, University of Sydney, Sydney, NSW 2006, Australia. 
      adelle.jee@sswahs.nsw.gov.au.
FAU - Adelstein, Stephen
AU  - Adelstein S
AD  - Sydney Medical School, University of Sydney, Sydney, NSW 2006, Australia. 
      stephen.adelstein@sydney.edu.au.
AD  - Immunopathology Laboratory, Southwest Sydney Pathology Service, Sydney, NSW 2050, 
      Australia. stephen.adelstein@sydney.edu.au.
AD  - Department of Clinical Immunology and Allergy, Royal Prince Alfred Hospital, 
      Sydney, NSW 2050, Australia. stephen.adelstein@sydney.edu.au.
FAU - Bleasel, Jane
AU  - Bleasel J
AD  - Sydney Medical School, University of Sydney, Sydney, NSW 2006, Australia. 
      jane.bleasel@sydney.edu.au.
AD  - Department of Rheumatology, Royal Prince Alfred Hospital, Sydney, NSW 2050, 
      Australia. jane.bleasel@sydney.edu.au.
FAU - Keir, Gregory J
AU  - Keir GJ
AD  - Department of Respiratory, Princess Alexandra Hospital, Woolloongabba, QLD 4102, 
      Australia. gregory_keir@health.qld.gov.au.
FAU - Nguyen, MaiAnh
AU  - Nguyen M
AD  - Sydney Medical School, University of Sydney, Sydney, NSW 2006, Australia. 
      maianh.nguyen@sswahs.nsw.gov.au.
AD  - Department of Clinical Immunology and Allergy, Royal Prince Alfred Hospital, 
      Sydney, NSW 2050, Australia. maianh.nguyen@sswahs.nsw.gov.au.
FAU - Sahhar, Joanne
AU  - Sahhar J
AD  - Department of Rheumatology, Monash Health, Clayton, VIC 3168, Australia. 
      josahhar@bigpond.com.
AD  - Department Medicine, Monash University, Clayton, VIC 3168, Australia. 
      josahhar@bigpond.com.
FAU - Youssef, Peter
AU  - Youssef P
AD  - Sydney Medical School, University of Sydney, Sydney, NSW 2006, Australia. 
      pyoussef@med.usyd.edu.au.
AD  - Department of Rheumatology, Royal Prince Alfred Hospital, Sydney, NSW 2050, 
      Australia. pyoussef@med.usyd.edu.au.
FAU - Corte, Tamera J
AU  - Corte TJ
AD  - Department of Respiratory and Sleep Medicine, Royal Prince Alfred Hospital, 
      Sydney, NSW 2050, Australia. tameracorte@me.com.
AD  - Sydney Medical School, University of Sydney, Sydney, NSW 2006, Australia. 
      tameracorte@me.com.
LA  - eng
PT  - Journal Article
PT  - Review
DEP - 20170504
PL  - Switzerland
TA  - J Clin Med
JT  - Journal of clinical medicine
JID - 101606588
PMC - PMC5447942
OTO - NOTNLM
OT  - autoantibodies
OT  - connective tissue disease
OT  - diagnosis
OT  - interstitial lung disease
OT  - interstitial pneumonia with autoimmune features
COIS- The authors declare no conflict of interest.
EDAT- 2017/05/05 06:00
MHDA- 2017/05/05 06:01
PMCR- 2017/05/04
CRDT- 2017/05/05 06:00
PHST- 2017/03/05 00:00 [received]
PHST- 2017/04/20 00:00 [revised]
PHST- 2017/04/29 00:00 [accepted]
PHST- 2017/05/05 06:00 [entrez]
PHST- 2017/05/05 06:00 [pubmed]
PHST- 2017/05/05 06:01 [medline]
PHST- 2017/05/04 00:00 [pmc-release]
AID - jcm6050051 [pii]
AID - jcm-06-00051 [pii]
AID - 10.3390/jcm6050051 [doi]
PST - epublish
SO  - J Clin Med. 2017 May 4;6(5):51. doi: 10.3390/jcm6050051.