PMID- 28471701
OWN - NLM
STAT- MEDLINE
DCOM- 20180529
LR  - 20180816
IS  - 2153-2176 (Electronic)
IS  - 2153-2168 (Linking)
VI  - 13
IP  - 5
DP  - 2017 Oct
TI  - The Brain-Derived Neurotrophic Factor Val66Met Polymorphism, Delivery Method, 
      Birth Weight, and Night Sleep Duration as Determinants of Obesity in Vietnamese 
      Children of Primary School Age.
PG  - 392-399
LID - 10.1089/chi.2017.0007 [doi]
AB  - BACKGROUND: Obesity is a complex disease that involves both environmental and 
      genetic factors in its pathogenesis. Several studies have identified multiple 
      obesity-associated loci in many populations. However, their contribution to 
      obesity in the Vietnamese population is not fully described, especially in 
      children. The study aimed to investigate the association of obesity with Val66Met 
      polymorphism in brain-derived neurotrophic factor (BDNF) gene, delivery method, 
      birth weight, and lifestyle factors in Vietnamese primary school children. 
      METHODS: A case-control study was conducted on 559 children aged 6-11 years (278 
      obese cases and 281 normal controls). The obesity of the children was classified 
      using both criteria of International Obesity Task Force (IOTF, 2000) and World 
      Health Organization (WHO, 2007). Lifestyle factors, birth delivery, and birth 
      weight of the children were self-reported by parents. The BDNF genotype was 
      analyzed using the polymerase chain reaction-restriction fragment length 
      polymorphism method. Association was evaluated by multivariate logistic 
      regression and cross-validated by the Bayesian model averaging method. RESULTS: 
      The most significantly independent factors for obesity were delivery method 
      (cesarean section vs. vaginal delivery, beta = 0.56, p = 0.007), birth weight (>3500 
      to <4000 g vs. 2500-3500 g, beta = 0.52, p = 0.035; >/=4000 g vs. 2500-3500 g, 
      beta = 1.06, p = 0.015), night sleep duration (<8 h/day vs. >/=8 h/day, beta = 0.99, 
      p < 0.0001), and BDNF Val66Met polymorphism (AA and GG vs. AG, beta = 0.38, 
      p = 0.039). CONCLUSIONS: The study suggested the significant association of 
      delivery method, birth weight, night sleep duration, and BDNF Val66Met 
      polymorphism, with obesity in Vietnamese primary school children.
FAU - Tuyet, Le Thi
AU  - Tuyet LT
AD  - 1 Department of Biology, Hanoi National University of Education , Hanoi, Vietnam 
      .
FAU - Nhung, Bui Thi
AU  - Nhung BT
AD  - 2 National Institute of Nutrition , Hanoi, Vietnam .
FAU - Dao, Duong Thi Anh
AU  - Dao DTA
AD  - 1 Department of Biology, Hanoi National University of Education , Hanoi, Vietnam 
      .
FAU - Hanh, Nguyen Thi Hong
AU  - Hanh NTH
AD  - 1 Department of Biology, Hanoi National University of Education , Hanoi, Vietnam 
      .
FAU - Tuyen, Le Danh
AU  - Tuyen LD
AD  - 2 National Institute of Nutrition , Hanoi, Vietnam .
FAU - Binh, Tran Quang
AU  - Binh TQ
AD  - 2 National Institute of Nutrition , Hanoi, Vietnam .
AD  - 3 Laboratory of Molecular Genetics, Department of Immunology and Molecular 
      Biology, National Institute of Hygiene and Epidemiology , Hanoi, Vietnam .
AD  - 4 Dinh Tien Hoang Institute of Medicine , Hanoi, Vietnam .
FAU - Thuc, Vu Thi Minh
AU  - Thuc VTM
AD  - 5 National Hospital of Otorhinolaryngology , Hanoi, Vietnam .
LA  - eng
PT  - Journal Article
DEP - 20170504
PL  - United States
TA  - Child Obes
JT  - Childhood obesity (Print)
JID - 101542497
RN  - 0 (Brain-Derived Neurotrophic Factor)
RN  - 7171WSG8A2 (BDNF protein, human)
SB  - IM
MH  - Birth Weight
MH  - Brain-Derived Neurotrophic Factor/*genetics
MH  - Case-Control Studies
MH  - Cesarean Section
MH  - Child
MH  - Delivery, Obstetric/methods
MH  - Female
MH  - Genetic Predisposition to Disease
MH  - Genotype
MH  - Humans
MH  - Life Style
MH  - Male
MH  - Pediatric Obesity/*genetics
MH  - Polymerase Chain Reaction
MH  - Polymorphism, Genetic/*genetics
MH  - Polymorphism, Restriction Fragment Length
MH  - Sleep
MH  - Time Factors
MH  - Vietnam
MH  - World Health Organization
OTO - NOTNLM
OT  - BDNF-rs6265
OT  - Vietnamese children
OT  - associated factors
OT  - obesity
EDAT- 2017/05/05 06:00
MHDA- 2018/05/31 06:00
CRDT- 2017/05/05 06:00
PHST- 2017/05/05 06:00 [pubmed]
PHST- 2018/05/31 06:00 [medline]
PHST- 2017/05/05 06:00 [entrez]
AID - 10.1089/chi.2017.0007 [doi]
PST - ppublish
SO  - Child Obes. 2017 Oct;13(5):392-399. doi: 10.1089/chi.2017.0007. Epub 2017 May 4.