PMID- 28471714
OWN - NLM
STAT- MEDLINE
DCOM- 20180207
LR  - 20220202
IS  - 1545-4126 (Electronic)
IS  - 0147-006X (Print)
IS  - 0147-006X (Linking)
VI  - 40
DP  - 2017 Jul 25
TI  - Circuits and Mechanisms for Surround Modulation in Visual Cortex.
PG  - 425-451
LID - 10.1146/annurev-neuro-072116-031418 [doi]
AB  - Surround modulation (SM) is a fundamental property of sensory neurons in many 
      species and sensory modalities. SM is the ability of stimuli in the surround of a 
      neuron's receptive field (RF) to modulate (typically suppress) the neuron's 
      response to stimuli simultaneously presented inside the RF, a property thought to 
      underlie optimal coding of sensory information and important perceptual 
      functions. Understanding the circuit and mechanisms for SM can reveal fundamental 
      principles of computations in sensory cortices, from mouse to human. Current 
      debate is centered over whether feedforward or intracortical circuits generate 
      SM, and whether this results from increased inhibition or reduced excitation. 
      Here we present a working hypothesis, based on theoretical and experimental 
      evidence, that SM results from feedforward, horizontal, and feedback interactions 
      with local recurrent connections, via synaptic mechanisms involving both 
      increased inhibition and reduced recurrent excitation. In particular, strong and 
      balanced recurrent excitatory and inhibitory circuits play a crucial role in the 
      computation of SM.
FAU - Angelucci, Alessandra
AU  - Angelucci A
AD  - Department of Ophthalmology and Visual Science, Moran Eye Institute, University 
      of Utah, Salt Lake City, Utah 84132; email: alessandra.angelucci@hsc.utah.edu , 
      ma.bijanzadeh@gmail.com , larsnurminen@gmail.com , sammerlin7@gmail.com , 
      freddieneuron@gmail.com.
FAU - Bijanzadeh, Maryam
AU  - Bijanzadeh M
AD  - Department of Ophthalmology and Visual Science, Moran Eye Institute, University 
      of Utah, Salt Lake City, Utah 84132; email: alessandra.angelucci@hsc.utah.edu , 
      ma.bijanzadeh@gmail.com , larsnurminen@gmail.com , sammerlin7@gmail.com , 
      freddieneuron@gmail.com.
FAU - Nurminen, Lauri
AU  - Nurminen L
AD  - Department of Ophthalmology and Visual Science, Moran Eye Institute, University 
      of Utah, Salt Lake City, Utah 84132; email: alessandra.angelucci@hsc.utah.edu , 
      ma.bijanzadeh@gmail.com , larsnurminen@gmail.com , sammerlin7@gmail.com , 
      freddieneuron@gmail.com.
FAU - Federer, Frederick
AU  - Federer F
AD  - Department of Ophthalmology and Visual Science, Moran Eye Institute, University 
      of Utah, Salt Lake City, Utah 84132; email: alessandra.angelucci@hsc.utah.edu , 
      ma.bijanzadeh@gmail.com , larsnurminen@gmail.com , sammerlin7@gmail.com , 
      freddieneuron@gmail.com.
FAU - Merlin, Sam
AU  - Merlin S
AD  - Department of Ophthalmology and Visual Science, Moran Eye Institute, University 
      of Utah, Salt Lake City, Utah 84132; email: alessandra.angelucci@hsc.utah.edu , 
      ma.bijanzadeh@gmail.com , larsnurminen@gmail.com , sammerlin7@gmail.com , 
      freddieneuron@gmail.com.
FAU - Bressloff, Paul C
AU  - Bressloff PC
AD  - Department of Mathematics, University of Utah, Salt Lake City, Utah 84132; email: 
      bressloff@math.utah.edu.
LA  - eng
GR  - R01 EY019743/EY/NEI NIH HHS/United States
GR  - U01 NS099702/NS/NINDS NIH HHS/United States
GR  - R01 EY026812/EY/NEI NIH HHS/United States
GR  - T32 EY024234/EY/NEI NIH HHS/United States
GR  - P30 EY014800/EY/NEI NIH HHS/United States
PT  - Journal Article
PT  - Research Support, N.I.H., Extramural
PT  - Research Support, Non-U.S. Gov't
PT  - Research Support, U.S. Gov't, Non-P.H.S.
PT  - Review
DEP - 20170503
PL  - United States
TA  - Annu Rev Neurosci
JT  - Annual review of neuroscience
JID - 7804039
SB  - IM
MH  - Animals
MH  - Feedback, Physiological/physiology
MH  - Models, Neurological
MH  - Neurons/*physiology
MH  - Photic Stimulation
MH  - Visual Cortex/*physiology
MH  - Visual Fields/physiology
MH  - Visual Pathways/*physiology
MH  - Visual Perception/*physiology
PMC - PMC5697758
MID - NIHMS919606
OTO - NOTNLM
OT  - extrastriate cortex
OT  - feedback
OT  - horizontal connection
OT  - primary visual cortex
OT  - recurrent circuits
OT  - striate cortex
EDAT- 2017/05/05 06:00
MHDA- 2018/02/08 06:00
PMCR- 2018/07/25
CRDT- 2017/05/05 06:00
PHST- 2017/05/05 06:00 [pubmed]
PHST- 2018/02/08 06:00 [medline]
PHST- 2017/05/05 06:00 [entrez]
PHST- 2018/07/25 00:00 [pmc-release]
AID - 10.1146/annurev-neuro-072116-031418 [doi]
PST - ppublish
SO  - Annu Rev Neurosci. 2017 Jul 25;40:425-451. doi: 
      10.1146/annurev-neuro-072116-031418. Epub 2017 May 3.