PMID- 28472871
OWN - NLM
STAT- PubMed-not-MEDLINE
LR  - 20201001
IS  - 1931-7573 (Print)
IS  - 1556-276X (Electronic)
IS  - 1556-276X (Linking)
VI  - 12
IP  - 1
DP  - 2017 Dec
TI  - ICAM-1-Targeted Liposomes Loaded with Liver X Receptor Agonists Suppress 
      PDGF-Induced Proliferation of Vascular Smooth Muscle Cells.
PG  - 322
LID - 10.1186/s11671-017-2097-6 [doi]
LID - 322
AB  - The proliferation of vascular smooth muscle cells (VSMCs) is one of the key 
      events during the progress of atherosclerosis. The activated liver X receptor 
      (LXR) signalling pathway is demonstrated to inhibit platelet-derived growth 
      factor BB (PDGF-BB)-induced VSMC proliferation. Notably, following PDGF-BB 
      stimulation, the expression of intercellular adhesion molecule-1 (ICAM-1) by 
      VSMCs increases significantly. In this study, anti-ICAM-1 antibody-conjugated 
      liposomes were fabricated for targeted delivery of a water-insoluble LXR agonist 
      (T0901317) to inhibit VSMC proliferation. The liposomes were prepared by 
      filming-rehydration method with uniform size distribution and considerable drug 
      entrapment efficiency. The targeting effect of the anti-ICAM-T0901317 liposomes 
      was evaluated by confocal laser scanning microscope (CLSM) and flow cytometry. 
      Anti-ICAM-T0901317 liposomes showed significantly higher inhibition effect of 
      VSMC proliferation than free T0901317 by CCk8 proliferation assays and BrdU 
      staining. Western blot assay further confirmed that anti-ICAM-T0901317 liposomes 
      inhibited retinoblastoma (Rb) phosphorylation and MCM6 expression. In conclusion, 
      this study identified anti-ICAM-T0901317 liposomes as a promising nanotherapeutic 
      approach to overcome VSMC proliferation during atherosclerosis progression.
FAU - Huang, Xu
AU  - Huang X
AD  - Department of Cardiology, State Key Laboratory of Kidney Diseases, Chinese PLA 
      General Hospital, Beijing, 100853, China.
FAU - Xu, Meng-Qi
AU  - Xu MQ
AD  - Department of Cardiology, State Key Laboratory of Kidney Diseases, Chinese PLA 
      General Hospital, Beijing, 100853, China.
FAU - Zhang, Wei
AU  - Zhang W
AD  - Laboratory of Controllable Nanopharmaceuticals, CAS Key Laboratory for Biomedical 
      Effects of Nanomaterials and Nanosafety, National Center for Nanoscience and 
      Technology, Beijing, 100190, China.
FAU - Ma, Sai
AU  - Ma S
AD  - Department of Cardiology, State Key Laboratory of Kidney Diseases, Chinese PLA 
      General Hospital, Beijing, 100853, China.
FAU - Guo, Weisheng
AU  - Guo W
AD  - Laboratory of Controllable Nanopharmaceuticals, CAS Key Laboratory for Biomedical 
      Effects of Nanomaterials and Nanosafety, National Center for Nanoscience and 
      Technology, Beijing, 100190, China.
FAU - Wang, Yabin
AU  - Wang Y
AD  - Department of Cardiology, State Key Laboratory of Kidney Diseases, Chinese PLA 
      General Hospital, Beijing, 100853, China.
FAU - Zhang, Yan
AU  - Zhang Y
AD  - Department of Cardiology, State Key Laboratory of Kidney Diseases, Chinese PLA 
      General Hospital, Beijing, 100853, China.
FAU - Gou, Tiantian
AU  - Gou T
AD  - Department of Cardiology, State Key Laboratory of Kidney Diseases, Chinese PLA 
      General Hospital, Beijing, 100853, China.
FAU - Chen, Yundai
AU  - Chen Y
AD  - Department of Cardiology, State Key Laboratory of Kidney Diseases, Chinese PLA 
      General Hospital, Beijing, 100853, China.
FAU - Liang, Xing-Jie
AU  - Liang XJ
AD  - Laboratory of Controllable Nanopharmaceuticals, CAS Key Laboratory for Biomedical 
      Effects of Nanomaterials and Nanosafety, National Center for Nanoscience and 
      Technology, Beijing, 100190, China. liangxj@nanoctr.cn.
FAU - Cao, Feng
AU  - Cao F
AUID- ORCID: 0000-0002-1010-6429
AD  - Department of Cardiology, State Key Laboratory of Kidney Diseases, Chinese PLA 
      General Hospital, Beijing, 100853, China. fengcao8828@163.com.
LA  - eng
PT  - Journal Article
DEP - 20170503
PL  - United States
TA  - Nanoscale Res Lett
JT  - Nanoscale research letters
JID - 101279750
PMC - PMC5415450
OTO - NOTNLM
OT  - ICAM-1
OT  - Liposome
OT  - Liver X receptor
OT  - Vascular smooth muscle cells
EDAT- 2017/05/06 06:00
MHDA- 2017/05/06 06:01
PMCR- 2017/05/03
CRDT- 2017/05/06 06:00
PHST- 2017/01/31 00:00 [received]
PHST- 2017/04/20 00:00 [accepted]
PHST- 2017/05/06 06:00 [entrez]
PHST- 2017/05/06 06:00 [pubmed]
PHST- 2017/05/06 06:01 [medline]
PHST- 2017/05/03 00:00 [pmc-release]
AID - 10.1186/s11671-017-2097-6 [pii]
AID - 2097 [pii]
AID - 10.1186/s11671-017-2097-6 [doi]
PST - ppublish
SO  - Nanoscale Res Lett. 2017 Dec;12(1):322. doi: 10.1186/s11671-017-2097-6. Epub 2017 
      May 3.