PMID- 28473776
OWN - NLM
STAT- PubMed-not-MEDLINE
LR  - 20201001
IS  - 1664-0640 (Print)
IS  - 1664-0640 (Electronic)
IS  - 1664-0640 (Linking)
VI  - 8
DP  - 2017
TI  - The Role of Trauma and Stressful Life Events among Individuals at Clinical High 
      Risk for Psychosis: A Review.
PG  - 55
LID - 10.3389/fpsyt.2017.00055 [doi]
LID - 55
AB  - The experience of childhood trauma (CT) and stressful life events (SLEs) is 
      associated with subsequent development of a variety of mental health conditions, 
      including psychotic illness. Recent research identifying adolescents and young 
      adults at clinical high risk (CHR) for psychosis allows for prospective 
      evaluation of the impact of trauma and adverse life events on psychosis onset and 
      other outcomes, addressing etiological questions that cannot be answered in 
      studies of fully psychotic or non-clinical populations. This article provides a 
      comprehensive review of the current emerging literature on trauma and adverse 
      life events in the CHR population. Up to 80% of CHR youth endorse a lifetime 
      history of childhood traumatic events and victimization (e.g., bullying). Several 
      studies have shown that the experience of CT predicts psychosis onset among CHR 
      individuals, while the literature on the influence of recent SLEs (e.g., death of 
      a loved one) remains inconclusive. Multiple models have been proposed to explain 
      the link between trauma and psychosis, including the stress-vulnerability and 
      stress-sensitivity hypotheses, with emphases on both cognitive processes and 
      neurobiological mechanisms (e.g., the hypothalamic-pituitary-adrenal axis). 
      Despite the preponderance of CHR individuals who endorse either CT or SLEs, no 
      clinical trials have been conducted evaluating interventions for trauma in CHR 
      youth to date. Furthermore, the current process of formal identification and 
      assessment of trauma, SLEs, and their impact on CHR youth is inconsistent in 
      research and clinical practice. Recommendations for improving trauma assessment, 
      treatment, and future research directions in the CHR field are provided.
FAU - Mayo, Danessa
AU  - Mayo D
AD  - Imaging Research Center, Department of Psychiatry and Behavioral Sciences, 
      University of California Davis, Sacramento, CA, USA.
FAU - Corey, Sarah
AU  - Corey S
AD  - Department of Psychiatry, University of California San Francisco, San Francisco, 
      CA, USA.
FAU - Kelly, Leah H
AU  - Kelly LH
AD  - Department of Psychiatry, University of California San Francisco, San Francisco, 
      CA, USA.
FAU - Yohannes, Seghel
AU  - Yohannes S
AD  - Department of Psychiatry, University of California San Francisco, San Francisco, 
      CA, USA.
FAU - Youngquist, Alyssa L
AU  - Youngquist AL
AD  - Department of Psychiatry, University of California San Francisco, San Francisco, 
      CA, USA.
FAU - Stuart, Barbara K
AU  - Stuart BK
AD  - Department of Psychiatry, University of California San Francisco, San Francisco, 
      CA, USA.
FAU - Niendam, Tara A
AU  - Niendam TA
AD  - Imaging Research Center, Department of Psychiatry and Behavioral Sciences, 
      University of California Davis, Sacramento, CA, USA.
FAU - Loewy, Rachel L
AU  - Loewy RL
AD  - Department of Psychiatry, University of California San Francisco, San Francisco, 
      CA, USA.
LA  - eng
PT  - Journal Article
PT  - Review
DEP - 20170420
PL  - Switzerland
TA  - Front Psychiatry
JT  - Frontiers in psychiatry
JID - 101545006
PMC - PMC5397482
OTO - NOTNLM
OT  - clinical high risk
OT  - early psychosis
OT  - schizophrenia
OT  - stressful life events
OT  - trauma
OT  - ultra-high risk
EDAT- 2017/05/06 06:00
MHDA- 2017/05/06 06:01
PMCR- 2017/04/20
CRDT- 2017/05/06 06:00
PHST- 2016/12/15 00:00 [received]
PHST- 2017/03/27 00:00 [accepted]
PHST- 2017/05/06 06:00 [entrez]
PHST- 2017/05/06 06:00 [pubmed]
PHST- 2017/05/06 06:01 [medline]
PHST- 2017/04/20 00:00 [pmc-release]
AID - 10.3389/fpsyt.2017.00055 [doi]
PST - epublish
SO  - Front Psychiatry. 2017 Apr 20;8:55. doi: 10.3389/fpsyt.2017.00055. eCollection 
      2017.