PMID- 28474577
OWN - NLM
STAT- PubMed-not-MEDLINE
LR  - 20201001
IS  - 2211-8020 (Print)
IS  - 2211-8039 (Electronic)
IS  - 2211-8020 (Linking)
VI  - 7
IP  - 1
DP  - 2017 Mar
TI  - Association of inflammatory cytokines with mortality in peritoneal dialysis 
      patients.
PG  - 1
LID - 10.1051/bmdcn/2017070101 [doi]
LID - 1
AB  - AIMS: Previous study on association between pro-inflammatory cytokines and 
      mortality in PD population is limited. We aimed to investigate here. METHODS: 
      Total 50 patients who underwent incident PD were enrolled in this study. We 
      measured the titers of pro-inflammatory cytokines Interleukin-18(IL-18), 
      Interleukin-6 (IL-6), and Interleukin-1ss (IL-1ss). Study outcomes were all-cause 
      mortality, cardiovascular-related mortality, and infection-caused mortality. 
      Cox-regression model was used. RESULTS: In this 7 year prospective study, IL-18 >/= 
      804.3pg/ml, IL-6 >/= 3.92 pg/ml, IL-1ss >/= 0.86pg/ml, age >/= 50 years-old, and 
      existence of diabetes could be used as individual significant predictors for 
      mortality in PD patients. Higher titers of IL-6 were associated with lower 
      averaging albumin levels within 1(st) year of PD. Increasing numbers of these 
      risk markers of mortality was associated with decreasing survival advantages (P = 
      0.001). CONCLUSION: Age >/= 50 years-old, diabetes, and inflammatory cytokines 
      profiles at the start of PD therapy could predict for 7-year mortality in PD 
      population.
CI  - (c) Author(s) 2017. This article is published with open access by China Medical 
      University.
FAU - Liu, Yao-Lung
AU  - Liu YL
AD  - Graduate Institute of Clinical Medical Science, China Medical University College 
      of Medicine, Taichung 404, Taiwan - Department of Internal Medicine, China 
      Medical University College of Medicine, Taichung 404, Taiwan - Division of 
      Nephrology, China Medical University Hospital, Taichung 404, Taiwan.
FAU - Liu, Jiung-Hsiun
AU  - Liu JH
AD  - Graduate Institute of Clinical Medical Science, China Medical University College 
      of Medicine, Taichung 404, Taiwan - Department of Internal Medicine, China 
      Medical University College of Medicine, Taichung 404, Taiwan - Division of 
      Nephrology, China Medical University Hospital, Taichung 404, Taiwan.
FAU - Wang, I-Kuan
AU  - Wang IK
AD  - Graduate Institute of Clinical Medical Science, China Medical University College 
      of Medicine, Taichung 404, Taiwan - Department of Internal Medicine, China 
      Medical University College of Medicine, Taichung 404, Taiwan - Division of 
      Nephrology, China Medical University Hospital, Taichung 404, Taiwan.
FAU - Ju, Shu-Woei
AU  - Ju SW
AD  - Department of Internal Medicine, China Medical University College of Medicine, 
      Taichung 404, Taiwan - Division of Nephrology, China Medical University Hospital, 
      Taichung 404, Taiwan.
FAU - Yu, Tung-Min
AU  - Yu TM
AD  - Graduate Institute of Clinical Medical Science, China Medical University College 
      of Medicine, Taichung 404, Taiwan - Division of Nephrology, Taichung Veteran 
      General Hospital, Taichung 407, Taiwan.
FAU - Chen, I-Ru
AU  - Chen IR
AD  - Department of Internal Medicine, China Medical University College of Medicine, 
      Taichung 404, Taiwan - Division of Nephrology, China Medical University Hospital, 
      Taichung 404, Taiwan.
FAU - Liu, Yu-Ching
AU  - Liu YC
AD  - Department of Medical Research, China Medical University Hospital, Taichung 404, 
      Taiwan.
FAU - Huang, Chung-Ming
AU  - Huang CM
AD  - Division of Immunology and Rheumatology, China Medical University Hospital, 
      Taichung 404, Taiwan - Graduate Institute of Integrated Medicine, China Medical 
      University, Taichung 404, Taiwan.
FAU - Lin, Shih-Yi
AU  - Lin SY
AD  - Graduate Institute of Clinical Medical Science, China Medical University College 
      of Medicine, Taichung 404, Taiwan - Department of Internal Medicine, China 
      Medical University College of Medicine, Taichung 404, Taiwan - Division of 
      Nephrology, China Medical University Hospital, Taichung 404, Taiwan.
FAU - Chang, Chiz-Tzung
AU  - Chang CT
AD  - Graduate Institute of Clinical Medical Science, China Medical University College 
      of Medicine, Taichung 404, Taiwan - Department of Internal Medicine, China 
      Medical University College of Medicine, Taichung 404, Taiwan - Division of 
      Nephrology, China Medical University Hospital, Taichung 404, Taiwan.
FAU - Huang, Chiu-Ching
AU  - Huang CC
AD  - Graduate Institute of Clinical Medical Science, China Medical University College 
      of Medicine, Taichung 404, Taiwan - Department of Internal Medicine, China 
      Medical University College of Medicine, Taichung 404, Taiwan - Division of 
      Nephrology, China Medical University Hospital, Taichung 404, Taiwan.
LA  - eng
PT  - Journal Article
DEP - 20170303
PL  - China (Republic : 1949- )
TA  - Biomedicine (Taipei)
JT  - BioMedicine
JID - 101611451
PMC - PMC5439334
EDAT- 2017/05/06 06:00
MHDA- 2017/05/06 06:01
PMCR- 2017/03/03
CRDT- 2017/05/06 06:00
PHST- 2016/09/12 00:00 [received]
PHST- 2016/09/29 00:00 [accepted]
PHST- 2017/05/06 06:00 [entrez]
PHST- 2017/05/06 06:00 [pubmed]
PHST- 2017/05/06 06:01 [medline]
PHST- 2017/03/03 00:00 [pmc-release]
AID - bmdcn2017070101 [pii]
AID - 10.1051/bmdcn/2017070101 [doi]
PST - ppublish
SO  - Biomedicine (Taipei). 2017 Mar;7(1):1. doi: 10.1051/bmdcn/2017070101. Epub 2017 
      Mar 3.