PMID- 28476179
OWN - NLM
STAT- MEDLINE
DCOM- 20170818
LR  - 20180301
IS  - 1556-5653 (Electronic)
IS  - 0015-0282 (Linking)
VI  - 107
IP  - 5
DP  - 2017 May
TI  - Current experience concerning mosaic embryos diagnosed during preimplantation 
      genetic screening.
PG  - 1113-1119
LID - S0015-0282(17)30289-3 [pii]
LID - 10.1016/j.fertnstert.2017.03.016 [doi]
AB  - The concept of embryos containing multiple cell lines (mosaicism) is not new, but 
      much attention has been paid to this concept recently owing to recent advances in 
      molecular techniques to analyze human embryos. Mosaicism in embryos has been 
      known and reported for some time, originally in early cleavage-stage embryos 
      diagnosed with the use of fluorescence in situ hybridization (FISH). However, the 
      early data have come under attack owing to the limited ability of FISH to 
      reliably detect the actual copy number count of chromosomes as well as potential 
      ascertainment bias of those early studies, which were all performed on already 
      analyzed embryos found to be aneuploid. More recent molecular techniques for 
      analyzing embryos have allowed scientists to really begin to understand mosaic 
      embryos, and to now transfer and follow this class of embryo. Indeed, it could be 
      said that three classes of embryos now exist after preimplantation genetic 
      screening: euploid, aneuploid, and mosaic aneuploid. This paper attempts to bring 
      to light the latest data on mosaic embryos and to understand how clinicians and 
      others will deal with this issue today and in the future. Finally, an attempt is 
      made to look to other fields of genetics to understand how this important issue 
      can be dealt with as a group much better than any one individual group may be 
      able to.
CI  - Copyright (c) 2017 American Society for Reproductive Medicine. Published by 
      Elsevier Inc. All rights reserved.
FAU - Harton, Gary L
AU  - Harton GL
AD  - Igenomix US, Miami, Florida. Electronic address: gary.harton@igenomix.com.
FAU - Cinnioglu, Cengiz
AU  - Cinnioglu C
AD  - Igenomix US, Miami, Florida.
FAU - Fiorentino, Francesco
AU  - Fiorentino F
AD  - Genoma Group, Molecular Genetics Laboratories Rome, Rome, Italy.
LA  - eng
PT  - Journal Article
PT  - Review
PL  - United States
TA  - Fertil Steril
JT  - Fertility and sterility
JID - 0372772
SB  - IM
EIN - Fertil Steril. 2017 Sep;108(3):554. PMID: 28865554
MH  - Chromosome Disorders/*embryology/*genetics/prevention & control
MH  - Clinical Decision-Making/ethics/methods
MH  - Embryo Implantation/*genetics
MH  - Embryo Transfer/ethics/*methods
MH  - Evidence-Based Medicine
MH  - Female
MH  - Genetic Counseling/ethics/methods
MH  - Genetic Testing/ethics/*methods
MH  - Humans
MH  - Mosaicism/*embryology
MH  - Preimplantation Diagnosis/ethics/*methods
OTO - NOTNLM
OT  - Mosaicism
OT  - comprehensive chromosome screening
OT  - inner cell mass
OT  - preimplantation genetic screening
OT  - trophectoderm
EDAT- 2017/05/10 06:00
MHDA- 2017/08/19 06:00
CRDT- 2017/05/07 06:00
PHST- 2016/12/29 00:00 [received]
PHST- 2017/03/15 00:00 [revised]
PHST- 2017/03/15 00:00 [accepted]
PHST- 2017/05/07 06:00 [entrez]
PHST- 2017/05/10 06:00 [pubmed]
PHST- 2017/08/19 06:00 [medline]
AID - S0015-0282(17)30289-3 [pii]
AID - 10.1016/j.fertnstert.2017.03.016 [doi]
PST - ppublish
SO  - Fertil Steril. 2017 May;107(5):1113-1119. doi: 10.1016/j.fertnstert.2017.03.016.