PMID- 28476205
OWN - NLM
STAT- MEDLINE
DCOM- 20180309
LR  - 20220408
IS  - 1532-3072 (Electronic)
IS  - 0040-8166 (Linking)
VI  - 49
IP  - 3
DP  - 2017 Jun
TI  - Therapeutic efficacy of human umbilical cord mesenchymal stem cells 
      transplantation against renal ischemia/reperfusion injury in rats.
PG  - 369-375
LID - S0040-8166(16)30171-9 [pii]
LID - 10.1016/j.tice.2017.04.006 [doi]
AB  - BACKGROUND: Acute kidney injury (AKI) is a common clinical problem raising the 
      urgent needs to develop new strategies for treatment. The present study 
      investigated the therapeutic potential of human umbilical cord - mesenchymal stem 
      cells (HUC-MSCs) transplantation against renal ischemia/reperfusion injury (IRI) 
      in rats. METHODS: Twenty four male Wistar rats were assigned into two main 
      groups, sham group (control group) and I/R group. I/R group was injected in the 
      tail vein with either phosphate buffer saline (PBS) or HUC-MSCs. RESULTS: The 
      HUC-MSCs improved kidney injury induced by I/R as demonstrated by enhancement of 
      the kidney function via decreasing serum levels of creatinine, urea and uric 
      acid. The therapeutic efficacy of HUC-MSCs were found to be mediated through 
      anti-oxidant activity as indicated by significant reduction in total 
      malondialdehyde (MDA) and significant increment in the levels of reduced 
      glutathione (GSH), catalase (CAT) and glutathione-S-transferase (GST). 
      CONCLUSION: The present work suggests that HUC-MSCs may be an effective 
      therapeutic agent against renal IRI. The recorded data showed improvement of 
      renal functions and urine albumin in HUC-MSCs than IRI group with positive 
      antioxidant efficacy of HUC-MSCs through scavenging free radicals and supporting 
      the antioxidant enzymes.
CI  - Copyright (c) 2017 Elsevier Ltd. All rights reserved.
FAU - Fahmy, Sohair R
AU  - Fahmy SR
AD  - Department of Zoology, Faculty of Science, Cairo University, Egypt.
FAU - Soliman, Amel M
AU  - Soliman AM
AD  - Department of Zoology, Faculty of Science, Cairo University, Egypt.
FAU - El Ansary, Mervat
AU  - El Ansary M
AD  - Department of Clinical and Chemical Pathological, Faculty of Medicine, Cairo 
      University, Kasr Al-Ainy, Egypt.
FAU - Elhamid, Samah Abd
AU  - Elhamid SA
AD  - Department of Clinical and Chemical Pathological, Faculty of Medicine, Cairo 
      University, Kasr Al-Ainy, Egypt. Electronic address: samah_cpath@yahoo.com.
FAU - Mohsen, Heba
AU  - Mohsen H
AD  - Department of Zoology, Faculty of Science, Cairo University, Egypt.
LA  - eng
PT  - Journal Article
DEP - 20170425
PL  - Scotland
TA  - Tissue Cell
JT  - Tissue & cell
JID - 0214745
SB  - IM
MH  - Animals
MH  - Heterografts
MH  - Humans
MH  - Kidney/*metabolism
MH  - Kidney Diseases/metabolism/*therapy
MH  - Male
MH  - *Mesenchymal Stem Cell Transplantation
MH  - Mesenchymal Stem Cells/cytology/*metabolism
MH  - Rats
MH  - Rats, Wistar
MH  - Reperfusion Injury/metabolism/*therapy
MH  - Umbilical Cord/cytology/*metabolism
OTO - NOTNLM
OT  - Antioxidant enzymes
OT  - Control group (sham group)
OT  - Human umbilical cord- mesenchymal stem cells (HUC-MSCs)
OT  - Oxidative stress
OT  - Renal ischemia/reperfusion injury
EDAT- 2017/05/10 06:00
MHDA- 2018/03/10 06:00
CRDT- 2017/05/07 06:00
PHST- 2016/07/31 00:00 [received]
PHST- 2017/04/21 00:00 [revised]
PHST- 2017/04/24 00:00 [accepted]
PHST- 2017/05/10 06:00 [pubmed]
PHST- 2018/03/10 06:00 [medline]
PHST- 2017/05/07 06:00 [entrez]
AID - S0040-8166(16)30171-9 [pii]
AID - 10.1016/j.tice.2017.04.006 [doi]
PST - ppublish
SO  - Tissue Cell. 2017 Jun;49(3):369-375. doi: 10.1016/j.tice.2017.04.006. Epub 2017 
      Apr 25.