PMID- 28477343
OWN - NLM
STAT- MEDLINE
DCOM- 20180926
LR  - 20181202
IS  - 1099-1611 (Electronic)
IS  - 1057-9249 (Linking)
VI  - 26
IP  - 12
DP  - 2017 Dec
TI  - Mindfulness-based cognitive therapy (MBCT) is cost-effective compared to a 
      wait-list control for persistent pain in women treated for primary breast 
      cancer-Results from a randomized controlled trial.
PG  - 2208-2214
LID - 10.1002/pon.4450 [doi]
AB  - OBJECTIVE: To investigate the cost-effectiveness of mindfulness-based cognitive 
      therapy (MBCT) compared to a wait-list control group for pain in women treated 
      for breast cancer. METHODS: A total of 129 women were randomly allocated to MBCT 
      or a wait-list control group. The primary outcome was the minimal clinically 
      important difference (MCID) on pain intensity (>/=2 point reduction on an 11-point 
      Numeric Rating Scale). Analyses were conducted from the health care system 
      perspective and included data on health care utilization and pain medication 
      retrieved from national registries for the period from baseline (T1) to 6 months 
      postintervention (T4). Bootstrap simulations were used to estimate confidence 
      intervals for the incremental cost and effect measures, and cost-effectiveness 
      acceptability curves. In sensitivity analyses, we replaced dropouts with 
      last-observation-carried-forward and tested consequences of higher costs of the 
      intervention. RESULTS: The intervention cost was 240euro per participant. The 
      average total cost from T1 to T4 in the MBCT group was 1706euro compared with 2436euro 
      in the control group (mean difference: 729euro, P = .07). More women in the MBCT 
      group (N:19/36; 52.8%) than in the control group (N:14/48; 29.2%) achieved an 
      MCID in pain intensity (OR=2.71, P = .03). The MBCT was cost-effective with a 
      probability of 85% with a value of an additional women achieving MCID set to zero 
      remained cost-effective with a probability of 70% to 82% when smaller effect and 
      higher MBCT costs were assumed. CONCLUSIONS: Our results suggest that MBCT is a 
      cost-effective pain intervention for women treated for breast cancer. Future 
      studies could include utility measures, indirect costs, and active control groups 
      to increase the generalizability and pragmatic value of the results.
CI  - Copyright (c) 2017 John Wiley & Sons, Ltd.
FAU - Johannsen, M
AU  - Johannsen M
AUID- ORCID: 0000-0002-7849-7534
AD  - Unit for Psychooncology and Health Psychology, Dept. of Oncology, Aarhus 
      University Hospital and Dept of Psychology, Aarhus University, Aarhus, Denmark.
AD  - Centre for Integrated Registry-Based Research (CIRRAU), Aarhus University, 
      Aarhus, Denmark.
FAU - Sorensen, J
AU  - Sorensen J
AD  - Centre for Health Economics Research, Dept of Public Health, University of 
      Southern Denmark, Odense C, Denmark.
AD  - Health Outcome Research Centre, Royal College of Surgeons in Ireland, Dublin 2, 
      Ireland.
FAU - O'Connor, M
AU  - O'Connor M
AD  - Unit for Psychooncology and Health Psychology, Dept. of Oncology, Aarhus 
      University Hospital and Dept of Psychology, Aarhus University, Aarhus, Denmark.
FAU - Jensen, A B
AU  - Jensen AB
AD  - Dept. of Oncology, Aarhus University Hospital, Aarhus, Denmark.
FAU - Zachariae, R
AU  - Zachariae R
AD  - Unit for Psychooncology and Health Psychology, Dept. of Oncology, Aarhus 
      University Hospital and Dept of Psychology, Aarhus University, Aarhus, Denmark.
LA  - eng
PT  - Journal Article
DEP - 20170531
PL  - England
TA  - Psychooncology
JT  - Psycho-oncology
JID - 9214524
SB  - IM
MH  - Adult
MH  - Breast Neoplasms/psychology/*therapy
MH  - Cancer Pain/rehabilitation/*therapy
MH  - Cognitive Behavioral Therapy/*economics/methods
MH  - Cost-Benefit Analysis
MH  - Female
MH  - Humans
MH  - Longitudinal Studies
MH  - Male
MH  - Middle Aged
MH  - Mindfulness/*economics/methods
MH  - Pain Management
MH  - Psychotherapy, Group
MH  - Randomized Controlled Trials as Topic
MH  - Treatment Outcome
MH  - *Waiting Lists
OTO - NOTNLM
OT  - cancer
OT  - cost analyses
OT  - cost-effectiveness
OT  - mindfulness
OT  - mindfulness-based intervention
OT  - oncology
OT  - pain
OT  - pain interventions
OT  - pain rehabilitation
OT  - persistent pain
EDAT- 2017/05/10 06:00
MHDA- 2018/09/27 06:00
CRDT- 2017/05/07 06:00
PHST- 2016/11/11 00:00 [received]
PHST- 2017/02/27 00:00 [revised]
PHST- 2017/04/27 00:00 [accepted]
PHST- 2017/05/10 06:00 [pubmed]
PHST- 2018/09/27 06:00 [medline]
PHST- 2017/05/07 06:00 [entrez]
AID - 10.1002/pon.4450 [doi]
PST - ppublish
SO  - Psychooncology. 2017 Dec;26(12):2208-2214. doi: 10.1002/pon.4450. Epub 2017 May 
      31.