PMID- 28477696
OWN - NLM
STAT- MEDLINE
DCOM- 20180223
LR  - 20220318
IS  - 1878-5883 (Electronic)
IS  - 0022-510X (Linking)
VI  - 377
DP  - 2017 Jun 15
TI  - Whipple's disease.
PG  - 197-206
LID - S0022-510X(17)30049-7 [pii]
LID - 10.1016/j.jns.2017.01.048 [doi]
AB  - Whipple's disease is a rare, chronic, systemic infectious disorder with prominent 
      intestinal manifestations. It presents with weight loss, arthralgia, diarrhea, 
      and abdominal pain. There are different entities of infection or carriage, 
      respectively, classical Whipple's disease, localized WD, and Isolated 
      Neurological WD. The disease is commonly diagnosed by biopsy of lymph node or 
      small-bowel. Histological detection within duodenal biopsies with "Periodic acid 
      Schiff" (PAS) staining still is first choice for the diagnosis of classical 
      Whipple's disease. PCR or immunohistochemistry can identify the agent more 
      specifically, and DNA sequencing for Tropheryma whipplei on lymphocytes from 
      blood and cerebrospinal fluid from PCR-positive specimens, is essential. 
      Cell-mediated immunity in active and inactive Whipple's disease has subtle 
      defects that might predispose some individuals to symptomatic infection with this 
      bacillus. Successful treatment can be achieved in most of the cases by 
      antimicrobial therapy. WD can be progressive lethal. Immune reconstitution 
      inflammatory syndrome (IRIS) might complicate the course of treatment and in 
      worst case end fatal.
CI  - Copyright (c) 2017. Published by Elsevier B.V.
FAU - El-Abassi, Rima
AU  - El-Abassi R
AD  - Department of Neurology, Louisiana State University Health Sciences Center, 
      School of Medicine, 1542 Tulane Avenue, New Orleans, LA 70112, United States. 
      Electronic address: rimaabassi@gmail.com.
FAU - Soliman, Michael Y
AU  - Soliman MY
AD  - Department of Neurology, Louisiana State University Health Sciences Center, 
      School of Medicine, 1542 Tulane Avenue, New Orleans, LA 70112, United States.
FAU - Williams, Frank
AU  - Williams F
AD  - Jefferson Neurological Associates, East Jefferson Neurological Associates, 3800 
      Houma Blvd Ste 205, Metairie, LA 70006, United States.
FAU - England, John D
AU  - England JD
AD  - Department of Neurology, Louisiana State University Health Sciences Center, 
      School of Medicine, 1542 Tulane Avenue, New Orleans, LA 70112, United States. 
      Electronic address: jengla@lsuhsc.edu.
LA  - eng
PT  - Journal Article
PT  - Review
DEP - 20170216
PL  - Netherlands
TA  - J Neurol Sci
JT  - Journal of the neurological sciences
JID - 0375403
SB  - IM
MH  - Humans
MH  - *Whipple Disease/diagnosis/physiopathology/therapy
OTO - NOTNLM
OT  - CNS Whipple disease
OT  - Treatment of Whipple disease
OT  - Tropheryma whipplei
OT  - Whipple disease
EDAT- 2017/05/10 06:00
MHDA- 2018/02/24 06:00
CRDT- 2017/05/08 06:00
PHST- 2015/08/27 00:00 [received]
PHST- 2016/12/16 00:00 [revised]
PHST- 2017/01/15 00:00 [accepted]
PHST- 2017/05/08 06:00 [entrez]
PHST- 2017/05/10 06:00 [pubmed]
PHST- 2018/02/24 06:00 [medline]
AID - S0022-510X(17)30049-7 [pii]
AID - 10.1016/j.jns.2017.01.048 [doi]
PST - ppublish
SO  - J Neurol Sci. 2017 Jun 15;377:197-206. doi: 10.1016/j.jns.2017.01.048. Epub 2017 
      Feb 16.