PMID- 28477725
OWN - NLM
STAT- MEDLINE
DCOM- 20180205
LR  - 20181113
IS  - 1873-6823 (Electronic)
IS  - 0741-8329 (Print)
IS  - 0741-8329 (Linking)
VI  - 60
DP  - 2017 May
TI  - Epigenetic mechanisms of alcoholism and stress-related disorders.
PG  - 7-18
LID - S0741-8329(16)30288-9 [pii]
LID - 10.1016/j.alcohol.2017.01.001 [doi]
AB  - Stress-related disorders, such as anxiety, early life stress, and posttraumatic 
      stress disorder appear to be important factors in promoting alcoholism, as 
      alcohol consumption can temporarily attenuate the negative affective symptoms of 
      these disorders. Several molecules involved in signaling pathways may contribute 
      to the neuroadaptation induced during alcohol dependence and stress disorders, 
      and among these, brain-derived neurotrophic factor (BDNF), corticotropin 
      releasing factor (CRF), neuropeptide Y (NPY) and opioid peptides (i.e., 
      nociceptin and dynorphin) are involved in the interaction of stress and alcohol. 
      In fact, alterations in the expression and function of these molecules have been 
      associated with the pathophysiology of stress-related disorders and alcoholism. 
      In recent years, various studies have focused on the epigenetic mechanisms that 
      regulate chromatin architecture, thereby modifying gene expression. 
      Interestingly, epigenetic modifications in specific brain regions have been shown 
      to be associated with the neurobiology of psychiatric disorders, including 
      alcoholism and stress. In particular, the enzymes responsible for chromatin 
      remodeling (i.e., histone deacetylases and methyltransferases, DNA 
      methyltransferases) have been identified as common molecular mechanisms for the 
      interaction of stress and alcohol and have become promising therapeutic targets 
      to treat or prevent alcoholism and associated emotional disorders.
CI  - Published by Elsevier Inc.
FAU - Palmisano, Martina
AU  - Palmisano M
AD  - Center for Alcohol Research in Epigenetics, Department of Psychiatry, University 
      of Illinois at Chicago, 1601 West Taylor Street, Chicago, IL 60612, USA.
FAU - Pandey, Subhash C
AU  - Pandey SC
AD  - Center for Alcohol Research in Epigenetics, Department of Psychiatry, University 
      of Illinois at Chicago, 1601 West Taylor Street, Chicago, IL 60612, USA; Jesse 
      Brown VA Medical Center, Chicago, IL 60612, USA. Electronic address: 
      scpandey@uic.edu.
LA  - eng
GR  - I01 BX000143/BX/BLRD VA/United States
GR  - R01 AA021662/AA/NIAAA NIH HHS/United States
GR  - U01 AA019971/AA/NIAAA NIH HHS/United States
GR  - R01 AA010005/AA/NIAAA NIH HHS/United States
GR  - U24 AA024605/AA/NIAAA NIH HHS/United States
GR  - P50 AA022538/AA/NIAAA NIH HHS/United States
PT  - Journal Article
PT  - Research Support, N.I.H., Extramural
PT  - Research Support, Non-U.S. Gov't
PT  - Research Support, U.S. Gov't, Non-P.H.S.
PT  - Review
DEP - 20170303
PL  - United States
TA  - Alcohol
JT  - Alcohol (Fayetteville, N.Y.)
JID - 8502311
RN  - 0 (Enzyme Inhibitors)
RN  - 0 (Histone Deacetylase Inhibitors)
RN  - 0 (Neuropeptides)
RN  - 0 (Opioid Peptides)
RN  - EC 2.1.1.- (DNA Modification Methylases)
SB  - IM
MH  - Alcohol Drinking/*genetics/metabolism/psychology
MH  - Alcoholism/drug therapy/*genetics/metabolism/psychology
MH  - Animals
MH  - Brain/drug effects/*metabolism/physiopathology
MH  - *DNA Methylation/drug effects
MH  - DNA Modification Methylases/antagonists & inhibitors
MH  - Emotions
MH  - Enzyme Inhibitors/therapeutic use
MH  - *Epigenesis, Genetic/drug effects
MH  - Histone Deacetylase Inhibitors/therapeutic use
MH  - Humans
MH  - Mood Disorders/drug therapy/*genetics/metabolism/psychology
MH  - Neuropeptides/metabolism
MH  - Opioid Peptides/metabolism
MH  - Signal Transduction
MH  - Stress, Psychological/drug therapy/*genetics/metabolism/psychology
PMC - PMC5464725
MID - NIHMS858934
OTO - NOTNLM
OT  - Alcohol
OT  - Anxiety
OT  - DNA methylation
OT  - Epigenetic
OT  - HDAC
OT  - Histone methylation
OT  - Stress
COIS- Conflict of interest: SCP reports that a US patent application entitled "Histone 
      acetyltransferase activators and histone deacetylase inhibitors in the treatment 
      of alcoholism" (serial number 60/848237 filed on September 29(th), 2006) is 
      currently pending. Other authors reported no biomedical financial interests or 
      potential conflicts of interest.
EDAT- 2017/05/10 06:00
MHDA- 2018/02/06 06:00
PMCR- 2018/05/01
CRDT- 2017/05/08 06:00
PHST- 2016/10/11 00:00 [received]
PHST- 2016/12/30 00:00 [revised]
PHST- 2017/01/03 00:00 [accepted]
PHST- 2017/05/08 06:00 [entrez]
PHST- 2017/05/10 06:00 [pubmed]
PHST- 2018/02/06 06:00 [medline]
PHST- 2018/05/01 00:00 [pmc-release]
AID - S0741-8329(16)30288-9 [pii]
AID - 10.1016/j.alcohol.2017.01.001 [doi]
PST - ppublish
SO  - Alcohol. 2017 May;60:7-18. doi: 10.1016/j.alcohol.2017.01.001. Epub 2017 Mar 3.