PMID- 28478829
OWN - NLM
STAT- MEDLINE
DCOM- 20180301
LR  - 20180301
IS  - 1532-2777 (Electronic)
IS  - 0306-9877 (Linking)
VI  - 102
DP  - 2017 May
TI  - The use of heparin in infertility and recurrent pregnancy loss: Are its antiviral 
      properties at play?
PG  - 41-47
LID - S0306-9877(16)30513-8 [pii]
LID - 10.1016/j.mehy.2017.03.009 [doi]
AB  - Recently, human herpesvirus 6 (HHV-6) has been implicated in cases of poor 
      pregnancy outcomes. The ability of HHV-6 to disrupt endothelial cell functioning 
      may inhibit the creation of an appropriate uterine environment for implantation 
      and fetal development, resulting in infertility and pregnancy loss, among other 
      complications. Heparin has been used to treat pregnant women who are predisposed 
      to thrombosis, and it has also been used in some women with infertility or 
      recurrent pregnancy loss without associated thrombotic events. Positive pregnancy 
      outcomes after heparin treatment in these groups indicate that heparin may alter 
      the uterine environment to make it more suitable for implantation and fetal 
      growth. In this paper, we propose that in some cases, heparin may accomplish this 
      by inhibiting HHV-6 transfer to the endometrium and/or by offsetting the 
      virally-mediated effects of endothelial cell injury.
CI  - Copyright (c) 2017 Elsevier Ltd. All rights reserved.
FAU - Eliassen, Eva
AU  - Eliassen E
AD  - HHV-6 Foundation, Santa Barbara, CA, United States. Electronic address: 
      eva@hhv-6foundation.org.
FAU - Marci, Roberto
AU  - Marci R
AD  - Obstetrics & Gynecology, University of Ferrera, Italy.
FAU - Di Luca, Dario
AU  - Di Luca D
AD  - Department of Medical Sciences, Microbiology and Medical Genetics, University of 
      Ferrara, Italy.
FAU - Rizzo, Roberta
AU  - Rizzo R
AD  - Department of Medical Sciences, Microbiology, University of Ferrara, Italy.
LA  - eng
PT  - Journal Article
DEP - 20170306
PL  - United States
TA  - Med Hypotheses
JT  - Medical hypotheses
JID - 7505668
RN  - 0 (Anticoagulants)
RN  - 9005-49-6 (Heparin)
SB  - IM
MH  - Abortion, Habitual/*prevention & control/*virology
MH  - Anticoagulants/administration & dosage
MH  - Embryo Implantation/drug effects
MH  - Female
MH  - Heparin/*administration & dosage
MH  - Herpesvirus 6, Human/*drug effects/*physiology
MH  - Humans
MH  - Infertility, Female/*prevention & control/*virology
MH  - Models, Biological
MH  - Pregnancy
MH  - Pregnancy Outcome
EDAT- 2017/05/10 06:00
MHDA- 2018/03/02 06:00
CRDT- 2017/05/09 06:00
PHST- 2016/08/27 00:00 [received]
PHST- 2017/03/05 00:00 [accepted]
PHST- 2017/05/09 06:00 [entrez]
PHST- 2017/05/10 06:00 [pubmed]
PHST- 2018/03/02 06:00 [medline]
AID - S0306-9877(16)30513-8 [pii]
AID - 10.1016/j.mehy.2017.03.009 [doi]
PST - ppublish
SO  - Med Hypotheses. 2017 May;102:41-47. doi: 10.1016/j.mehy.2017.03.009. Epub 2017 
      Mar 6.