PMID- 28479383
OWN - NLM
STAT- MEDLINE
DCOM- 20170727
LR  - 20170727
IS  - 1879-0038 (Electronic)
IS  - 0378-1119 (Linking)
VI  - 626
DP  - 2017 Aug 30
TI  - Association of irisin and FNDC5 rs16835198 G>T gene polymorphism with type 2 
      diabetes mellitus and diabetic nephropathy. An Egyptian pilot study.
PG  - 26-31
LID - S0378-1119(17)30334-7 [pii]
LID - 10.1016/j.gene.2017.05.010 [doi]
AB  - Diabetes mellitus is a fast-growing health problem in Egypt affecting morbidity, 
      mortality and health care resources. Irisin, a new exercise-induced myokine 
      inducing browning of white adipose tissues, has gained a great interest as a 
      potential new target for combating type 2 diabetes mellitus (T2DM) and its 
      complications. In this study, we assessed serum irisin levels in T2DM and 
      diabetic nephropathy to elucidate possible relationships between irisin and 
      metabolic parameters and renal functions. We also investigated, for the first 
      time in Egypt, the association of FNDC5 rs16835198 G>T polymorphism with T2DM, 
      diabetic nephropathy and irisin levels. One hundred type 2 diabetic patients (40 
      normoalbuminuric and 60 with nephropathy) as well as fifty control subjects were 
      enrolled in this study. Serum irisin and insulin were evaluated by ELISA. Genomic 
      DNA was genotyped for FNDC5 rs16835198 polymorphism using TaqMan genotyping 
      assay. Serum irisin levels were lower in diabetic patients compared to controls 
      and this decrease was more pronounced in diabetic nephropathy. Irisin correlates 
      with metabolic parameters and renal functions. Frequencies of T allele and TT 
      genotype were significantly lower among T2DM and diabetic nephropathy patients 
      compared to controls. Moreover, G allele was associated with elevated insulin 
      resistance and dyslipidemia without effect on circulating irisin levels. IN 
      CONCLUSION: T2DM and diabetic nephropathy are associated with decreased levels of 
      irisin. FNDC5 rs16835198 TT genotype associates with decreased risk of T2DM in 
      Egyptians with no effect on renal complications. Also, G allele has insulin 
      desensitizing action with no association with circulating irisin levels.
CI  - Copyright (c) 2017 Elsevier B.V. All rights reserved.
FAU - Khidr, Emad Gamil
AU  - Khidr EG
AD  - Biochemistry Department, Faculty of Pharmacy (Boys), Al-Azhar University, Cairo, 
      Egypt. Electronic address: Emadgamil2003@azhar.edu.eg.
FAU - Ali, Shawkey Saddik
AU  - Ali SS
AD  - Biochemistry Department, Faculty of Pharmacy (Boys), Al-Azhar University, Cairo, 
      Egypt.
FAU - Elshafey, Mostafa Mahmoud
AU  - Elshafey MM
AD  - Biochemistry Department, Faculty of Pharmacy (Boys), Al-Azhar University, Cairo, 
      Egypt.
FAU - Fawzy, Olfat Ahmed
AU  - Fawzy OA
AD  - Al-Zahraa Hospital, Al-Azhar University, Abbassia, Cairo, Egypt.
LA  - eng
PT  - Journal Article
DEP - 20170504
PL  - Netherlands
TA  - Gene
JT  - Gene
JID - 7706761
RN  - 0 (FNDC5 protein, human)
RN  - 0 (Fibronectins)
SB  - IM
MH  - Adult
MH  - Case-Control Studies
MH  - Diabetes Mellitus, Type 2/blood/complications/*genetics
MH  - Diabetic Nephropathies/blood/*genetics
MH  - Dyslipidemias/etiology/*genetics
MH  - Egypt
MH  - Fibronectins/blood/*genetics
MH  - Humans
MH  - Insulin Resistance/genetics
MH  - Male
MH  - Pilot Projects
MH  - *Polymorphism, Single Nucleotide
OTO - NOTNLM
OT  - Browning
OT  - Diabetes mellitus
OT  - Diabetic nephropathy
OT  - Irisin
OT  - Polymorphism
EDAT- 2017/05/10 06:00
MHDA- 2017/07/28 06:00
CRDT- 2017/05/09 06:00
PHST- 2017/03/14 00:00 [received]
PHST- 2017/04/25 00:00 [revised]
PHST- 2017/05/03 00:00 [accepted]
PHST- 2017/05/10 06:00 [pubmed]
PHST- 2017/07/28 06:00 [medline]
PHST- 2017/05/09 06:00 [entrez]
AID - S0378-1119(17)30334-7 [pii]
AID - 10.1016/j.gene.2017.05.010 [doi]
PST - ppublish
SO  - Gene. 2017 Aug 30;626:26-31. doi: 10.1016/j.gene.2017.05.010. Epub 2017 May 4.