PMID- 28479387
OWN - NLM
STAT- MEDLINE
DCOM- 20170727
LR  - 20170727
IS  - 1879-0038 (Electronic)
IS  - 0378-1119 (Linking)
VI  - 626
DP  - 2017 Aug 30
TI  - The effects of TLR3, TRIF and TRAF3 SNPs and interactions with environmental 
      factors on type 2 diabetes mellitus and vascular complications in a Han Chinese 
      population.
PG  - 41-47
LID - S0378-1119(17)30333-5 [pii]
LID - 10.1016/j.gene.2017.05.011 [doi]
AB  - Toll-like receptor 3 (TLR3) is involved in type I interferon-beta (IFN-beta) via 
      TIR-domain-containing adapter-inducing interferon-beta (TRIF) and Tumor necrosis 
      factor receptor-associated factor 3 (TRAF3), culminating in inflammation and 
      immunity reactions. TLR3 is implicated in insulin resistance and type 2 diabetes 
      mellitus (T2DM). Eight SNPs of these genes were detected in 552 T2DM patients and 
      552 matched healthy control subjects. Gene-gene and gene-environment interactions 
      and haplotype associations were also evaluated. We identified a 21% increased 
      risk of T2DM for the T allele of rs12435483 in the TRAF3 gene (OR: 1.21; 95% CI: 
      1.01-1.44; P=0.036). The GA genotype and GA+AA genotype of TRAF3 rs12147254 were 
      found to increase the risk of coronary heart disease (CHD) among T2DM patients 
      (GA vs. GG: OR=4.17, 95% CI: 1.04-16.79, P=0.045; GA+AA vs. GG: OR=3.97, 95% CI: 
      1.02-15.48, P=0.047). However, the GACGAC haplotype in TRAF3 had a protective 
      effect on T2DM micro-macrovascular complications (OR=0.33, 95% CI: 0.13-0.85, 
      P=0.017). Two-factor (TRAF3 rs12435483 and LDL) and three-factor (TRAF3 
      rs12435483, BMI and HDL) interactions of the risk of T2DM were identified. In 
      conclusion, the genetic variants in the TLR3-TRIF-TRAF3-INF-beta signaling pathway 
      and interactions with some particular environmental factors (LDL, BMI and HDL) 
      may contribute to susceptibility to T2DM and vascular complications in the Han 
      Chinese population.
CI  - Copyright (c) 2017. Published by Elsevier B.V.
FAU - Zhou, Zixing
AU  - Zhou Z
AD  - Department of Epidemiology, School of Medicine, Jinan University, Guangzhou, 
      China.
FAU - Zeng, Chengli
AU  - Zeng C
AD  - Department of Epidemiology, School of Medicine, Jinan University, Guangzhou, 
      China.
FAU - Nie, Lihong
AU  - Nie L
AD  - Department of Endocrine, The First Affiliated Hospital of Jinan University, 
      Guangzhou, China.
FAU - Huang, Shiqi
AU  - Huang S
AD  - Department of Epidemiology, School of Medicine, Jinan University, Guangzhou, 
      China.
FAU - Guo, Congcong
AU  - Guo C
AD  - Department of Epidemiology, School of Medicine, Jinan University, Guangzhou, 
      China.
FAU - Xiao, Di
AU  - Xiao D
AD  - Department of Epidemiology, School of Medicine, Jinan University, Guangzhou, 
      China.
FAU - Han, Yajing
AU  - Han Y
AD  - Department of Epidemiology, School of Medicine, Jinan University, Guangzhou, 
      China.
FAU - Ye, Xiaohong
AU  - Ye X
AD  - Department of Epidemiology, School of Medicine, Jinan University, Guangzhou, 
      China.
FAU - Ou, Meiling
AU  - Ou M
AD  - Department of Epidemiology, School of Medicine, Jinan University, Guangzhou, 
      China.
FAU - Huang, Chuican
AU  - Huang C
AD  - Department of Epidemiology, School of Medicine, Jinan University, Guangzhou, 
      China.
FAU - Ye, Xingguang
AU  - Ye X
AD  - Department of Epidemiology, School of Medicine, Jinan University, Guangzhou, 
      China.
FAU - Wen, Zihao
AU  - Wen Z
AD  - Department of Epidemiology, School of Medicine, Jinan University, Guangzhou, 
      China.
FAU - Yang, Guang
AU  - Yang G
AD  - Department of Parasitology, School of Medicine, Jinan University, Guangzhou, 
      China; Guangzhou Key Laboratory of Environmental Exposure and Health, Guangdong 
      Key Laboratory of Environmental Pollution and Health, Jinan University, 
      Guangzhou, Guangdong, China. Electronic address: guangyangphd@gmail.com.
FAU - Jing, Chunxia
AU  - Jing C
AD  - Department of Epidemiology, School of Medicine, Jinan University, Guangzhou, 
      China; Guangzhou Key Laboratory of Environmental Exposure and Health, Guangdong 
      Key Laboratory of Environmental Pollution and Health, Jinan University, 
      Guangzhou, Guangdong, China. Electronic address: jcxphd@gmail.com.
LA  - eng
PT  - Journal Article
DEP - 20170504
PL  - Netherlands
TA  - Gene
JT  - Gene
JID - 7706761
RN  - 0 (Adaptor Proteins, Vesicular Transport)
RN  - 0 (TICAM1 protein, human)
RN  - 0 (TLR3 protein, human)
RN  - 0 (TNF Receptor-Associated Factor 3)
RN  - 0 (TRAF3 protein, human)
RN  - 0 (Toll-Like Receptor 3)
SB  - IM
MH  - Adaptor Proteins, Vesicular Transport/*genetics
MH  - Aged
MH  - Case-Control Studies
MH  - China
MH  - Diabetes Mellitus, Type 2/complications/*genetics
MH  - Diabetic Angiopathies/*genetics
MH  - Female
MH  - *Gene-Environment Interaction
MH  - Humans
MH  - Male
MH  - Middle Aged
MH  - *Polymorphism, Single Nucleotide
MH  - TNF Receptor-Associated Factor 3/*genetics
MH  - Toll-Like Receptor 3/*genetics
OTO - NOTNLM
OT  - Polymorphism
OT  - T2DM
OT  - TLR3
OT  - TRAF3
OT  - TRIF
EDAT- 2017/05/10 06:00
MHDA- 2017/07/28 06:00
CRDT- 2017/05/09 06:00
PHST- 2017/02/06 00:00 [received]
PHST- 2017/04/21 00:00 [revised]
PHST- 2017/05/03 00:00 [accepted]
PHST- 2017/05/10 06:00 [pubmed]
PHST- 2017/07/28 06:00 [medline]
PHST- 2017/05/09 06:00 [entrez]
AID - S0378-1119(17)30333-5 [pii]
AID - 10.1016/j.gene.2017.05.011 [doi]
PST - ppublish
SO  - Gene. 2017 Aug 30;626:41-47. doi: 10.1016/j.gene.2017.05.011. Epub 2017 May 4.