PMID- 28480165
OWN - NLM
STAT- PubMed-not-MEDLINE
LR  - 20231112
IS  - 2213-6304 (Print)
IS  - 2213-6312 (Electronic)
IS  - 2213-6304 (Linking)
VI  - 1
IP  - 1
DP  - 2015
TI  - FNDC5/irisin - their role in the nervous system and as a mediator for beneficial 
      effects of exercise on the brain.
PG  - 55-61
LID - 10.3233/BPL-150019 [doi]
AB  - Exercise can improve cognitive function and the outcome of neurodegenerative 
      diseases, like Alzheimer's disease. This effect has been linked to the increased 
      expression of brain-derived neurotrophic factor (BDNF). However, the underlying 
      molecular mechanisms driving the elevation of this neurotrophin remain unknown. 
      Recently, we have reported a PGC-1alpha-FNDC5/irisin pathway, which is activated by 
      exercise in the hippocampus in mice and induces a neuroprotective gene program, 
      including Bdnf. This review will focus on FNDC5 and its secreted form "irisin", a 
      newly discovered myokine, and their role in the nervous system and its 
      therapeutic potential. In addition, we will briefly discuss the role of other 
      exercise-induced myokines on positive brain effects.
FAU - Wrann, Christiane D
AU  - Wrann CD
AD  - Dana-Farber Cancer Institute and Department of Cell Biology, Harvard Medical 
      School, 44 Binney Street, Boston, MA 02115, USA.
LA  - eng
GR  - K99 NS087096/NS/NINDS NIH HHS/United States
GR  - RC4 DK090861/DK/NIDDK NIH HHS/United States
GR  - R37 DK031405/DK/NIDDK NIH HHS/United States
GR  - R00 NS087096/NS/NINDS NIH HHS/United States
GR  - R01 DK031405/DK/NIDDK NIH HHS/United States
PT  - Journal Article
PL  - Netherlands
TA  - Brain Plast
JT  - Brain plasticity (Amsterdam, Netherlands)
JID - 101669568
PMC - PMC5419585
MID - NIHMS819596
OTO - NOTNLM
OT  - BDNF
OT  - Exercise
OT  - FNDC5
OT  - brain
OT  - cognition
OT  - hippocampus
OT  - irisin
OT  - physical activity
EDAT- 2015/01/01 00:00
MHDA- 2015/01/01 00:01
PMCR- 2015/10/09
CRDT- 2017/05/09 06:00
PHST- 2017/05/09 06:00 [entrez]
PHST- 2015/01/01 00:00 [pubmed]
PHST- 2015/01/01 00:01 [medline]
PHST- 2015/10/09 00:00 [pmc-release]
AID - BPL150019 [pii]
AID - 10.3233/BPL-150019 [doi]
PST - ppublish
SO  - Brain Plast. 2015;1(1):55-61. doi: 10.3233/BPL-150019.