PMID- 28482124
OWN - NLM
STAT- MEDLINE
DCOM- 20191009
LR  - 20191010
IS  - 1932-7005 (Electronic)
IS  - 1932-6254 (Linking)
VI  - 12
IP  - 2
DP  - 2018 Feb
TI  - Collagen scaffold combined with human umbilical cord-derived mesenchymal stem 
      cells promote functional recovery after scar resection in rats with chronic 
      spinal cord injury.
PG  - e1154-e1163
LID - 10.1002/term.2450 [doi]
AB  - Effective therapeutic strategies for treating chronic spinal cord injury (SCI) 
      are currently unavailable. Scar tissue in the lesion area is a main inhibitory 
      factor for axonal regeneration and repair of chronic SCI. In this study, scar 
      tissue was surgically resected from adult rats with 12 week chronic SCI and then 
      collagen scaffold (NeuroRegen Scaffold; NRS) and human umbilical cord-derived 
      mesenchymal stem cells (hUC-MSCs) were implanted into the resected cavity to 
      repair chronic SCI. The results demonstrated that the locomotor function of rats 
      was not affected by surgical scar resection, indicating its safety in treating 
      chronic SCI. Implanting NRS and hUC-MSCs promoted locomotion in rats and improved 
      cortical motor- and somatosensory-evoked potentials. Furthermore, implanting NRS 
      and hUC-MSCs promoted neurofilament- and beta-tubulin-III-positive neural 
      regeneration and remyelination, elicited beta-tubulin-III-positive neuron production 
      in the lesion area and blocked astrocyte growth outside the lesion area. In 
      conclusion, implanting NRS in combination with hUC-MSCs provided a beneficial 
      microenvironment for neural regeneration, showing significant therapeutic effects 
      for chronic SCI.
CI  - Copyright (c) 2017 John Wiley & Sons, Ltd.
FAU - Wang, Nuo
AU  - Wang N
AD  - Key Laboratory of Molecular Developmental Biology, Institute of Genetics and 
      Developmental Biology, Chinese Academy of Sciences, Beijing, China.
FAU - Xiao, Zhifeng
AU  - Xiao Z
AD  - Key Laboratory of Molecular Developmental Biology, Institute of Genetics and 
      Developmental Biology, Chinese Academy of Sciences, Beijing, China.
FAU - Zhao, Yannan
AU  - Zhao Y
AD  - Key Laboratory of Molecular Developmental Biology, Institute of Genetics and 
      Developmental Biology, Chinese Academy of Sciences, Beijing, China.
FAU - Wang, Bin
AU  - Wang B
AD  - Key Laboratory of Molecular Developmental Biology, Institute of Genetics and 
      Developmental Biology, Chinese Academy of Sciences, Beijing, China.
FAU - Li, Xing
AU  - Li X
AD  - Key Laboratory of Molecular Developmental Biology, Institute of Genetics and 
      Developmental Biology, Chinese Academy of Sciences, Beijing, China.
FAU - Li, Jing
AU  - Li J
AD  - Key Laboratory of Molecular Developmental Biology, Institute of Genetics and 
      Developmental Biology, Chinese Academy of Sciences, Beijing, China.
FAU - Dai, Jianwu
AU  - Dai J
AUID- ORCID: 0000-0002-3379-9053
AD  - Key Laboratory of Molecular Developmental Biology, Institute of Genetics and 
      Developmental Biology, Chinese Academy of Sciences, Beijing, China.
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20170801
PL  - England
TA  - J Tissue Eng Regen Med
JT  - Journal of tissue engineering and regenerative medicine
JID - 101308490
RN  - 0 (Glial Fibrillary Acidic Protein)
RN  - 0 (Tubulin)
RN  - 9007-34-5 (Collagen)
SB  - IM
MH  - Animals
MH  - Animals, Newborn
MH  - Astrocytes/metabolism
MH  - Axons/metabolism
MH  - Cattle
MH  - Chronic Disease
MH  - Cicatrix/pathology/*therapy
MH  - Collagen/*pharmacology
MH  - Female
MH  - Glial Fibrillary Acidic Protein/metabolism
MH  - Humans
MH  - Locomotion/drug effects
MH  - Mesenchymal Stem Cell Transplantation
MH  - Mesenchymal Stem Cells/*cytology
MH  - Myelin Sheath/metabolism
MH  - Nerve Regeneration/drug effects
MH  - Pyramidal Tracts/drug effects/physiology
MH  - Rats, Sprague-Dawley
MH  - *Recovery of Function/drug effects
MH  - Spinal Cord Injuries/*pathology/*physiopathology
MH  - Tissue Scaffolds/*chemistry
MH  - Tubulin/metabolism
MH  - Umbilical Cord/*cytology
OTO - NOTNLM
OT  - chronic spinal cord injury
OT  - collagen
OT  - functional recovery
OT  - human umbilical cord-derived mesenchymal stem cell
OT  - neural regeneration
OT  - surgical scar resection
EDAT- 2017/05/10 06:00
MHDA- 2019/10/11 06:00
CRDT- 2017/05/09 06:00
PHST- 2016/06/14 00:00 [received]
PHST- 2017/01/17 00:00 [revised]
PHST- 2017/05/04 00:00 [accepted]
PHST- 2017/05/10 06:00 [pubmed]
PHST- 2019/10/11 06:00 [medline]
PHST- 2017/05/09 06:00 [entrez]
AID - 10.1002/term.2450 [doi]
PST - ppublish
SO  - J Tissue Eng Regen Med. 2018 Feb;12(2):e1154-e1163. doi: 10.1002/term.2450. Epub 
      2017 Aug 1.