PMID- 28482546
OWN - NLM
STAT- MEDLINE
DCOM- 20180220
LR  - 20181202
IS  - 1873-0191 (Electronic)
IS  - 0928-4931 (Linking)
VI  - 76
DP  - 2017 Jul 1
TI  - A simple and sensitive methodology for voltammetric determination of valproic 
      acid in human blood plasma samples using 3-aminopropyletriethoxy silane coated 
      magnetic nanoparticles modified pencil graphite electrode.
PG  - 425-430
LID - S0928-4931(16)31874-4 [pii]
LID - 10.1016/j.msec.2017.02.140 [doi]
AB  - In this work, we have prepared a nano-material modified pencil graphite electrode 
      for the sensing of valproic acid (VA) by immobilization 3-aminopropyletriethoxy 
      silane coated magnetic nanoparticles (APTES-MNPs) on the pencil graphite surface 
      (PGE). Electrochemical studies indicated that the APTES-MNPs efficiently 
      increased the electron transfer kinetics between VA and the electrode and the 
      free NH(2) groups of the APTES on the outer surface of magnetic nanoparticles can 
      interact with carboxyl groups of VA. Based on this, we have proposed a sensitive, 
      rapid and convenient electrochemical method for VA determination. Under the 
      optimized conditions, the reduction peak current of VA is found to be 
      proportional to its concentration in the range of 1.0 (+/-0.2) to 100.0 (+/-0.3) ppm 
      with a detection limit of 0.4 (+/-0.1) ppm. The whole sensor fabrication process 
      was characterized by cyclic voltammetry (CV) and electrochemical impedance 
      spectroscopy (EIS) methods with using [Fe(CN)(6)](3-/4-)as an electrochemical 
      redox indicator. The prepared modified electrode showed several advantages such 
      as high sensitivity, selectivity, ease of preparation and good repeatability, 
      reproducibility and stability. The proposed method was applied to determination 
      of valproic acid in blood plasma samples and the obtained results were 
      satisfactory accurate.
CI  - Copyright (c) 2017. Published by Elsevier B.V.
FAU - Zabardasti, Abedin
AU  - Zabardasti A
AD  - Department of Chemistry, Faculty of Science, Lorestan University, Khorramabad, 
      Iran. Electronic address: zabardasti.a@lu.ac.ir.
FAU - Afrouzi, Hossein
AU  - Afrouzi H
AD  - Department of Chemistry, Faculty of Science, Lorestan University, Khorramabad, 
      Iran.
FAU - Talemi, Rasoul Pourtaghavi
AU  - Talemi RP
AD  - Faculty of Chemistry, Kharazmi University, Tehran, Iran.
LA  - eng
PT  - Journal Article
DEP - 20170227
PL  - Netherlands
TA  - Mater Sci Eng C Mater Biol Appl
JT  - Materials science & engineering. C, Materials for biological applications
JID - 101484109
RN  - 0 (Magnetite Nanoparticles)
RN  - 0 (Silanes)
RN  - 614OI1Z5WI (Valproic Acid)
RN  - 7782-42-5 (Graphite)
SB  - IM
MH  - Electrodes
MH  - Graphite
MH  - Humans
MH  - *Magnetite Nanoparticles
MH  - Reproducibility of Results
MH  - Silanes
MH  - Valproic Acid
OTO - NOTNLM
OT  - Differential pulse voltammetry
OT  - Electrochemicalimpedance spectroscopy
OT  - Magnetic nanoparticles
OT  - Pencil graphite electrode
OT  - Plasma
OT  - Valproicacid
EDAT- 2017/05/10 06:00
MHDA- 2018/02/21 06:00
CRDT- 2017/05/10 06:00
PHST- 2016/10/23 00:00 [received]
PHST- 2016/12/11 00:00 [revised]
PHST- 2017/02/24 00:00 [accepted]
PHST- 2017/05/10 06:00 [entrez]
PHST- 2017/05/10 06:00 [pubmed]
PHST- 2018/02/21 06:00 [medline]
AID - S0928-4931(16)31874-4 [pii]
AID - 10.1016/j.msec.2017.02.140 [doi]
PST - ppublish
SO  - Mater Sci Eng C Mater Biol Appl. 2017 Jul 1;76:425-430. doi: 
      10.1016/j.msec.2017.02.140. Epub 2017 Feb 27.