PMID- 28483674
OWN - NLM
STAT- MEDLINE
DCOM- 20180309
LR  - 20180919
IS  - 1878-4216 (Electronic)
IS  - 0278-5846 (Linking)
VI  - 78
DP  - 2017 Aug 1
TI  - The postnatal 5-HT(1A) receptor regulates adult anxiety and depression 
      differently via multiple molecules.
PG  - 66-74
LID - S0278-5846(16)30362-1 [pii]
LID - 10.1016/j.pnpbp.2017.04.014 [doi]
AB  - Serotonin (5-HT) and the 5-HT(1A) receptor during development are known to 
      modulate anxiety and depression in later life. However, the brain mechanisms 
      linking the postnatal 5-HT system and adult behavior remain unknown. Here, we 
      examined the effects of pharmacological 5-HT(1A) receptor activation during the 
      postnatal period on anxiety and depression-like behavior in adult BALB/c male 
      mice. To elucidate the underlying mechanisms, we measured mRNA expression of the 
      5-HT(1A) receptor, brain-derived neurotrophic factor (BDNF), GABA(A) receptor 
      subunits, and AMPA receptor subunits in the medial prefrontal cortex (mPFC), 
      amygdala, and hippocampus. Treatment with the selective 5-HT reuptake inhibitor 
      (fluoxetine) and 5-HT(1A) receptor agonist (8-OH-DPAT) during the postnatal 
      period decreased anxiety-like behavior in adulthood, whereas only 8-OH-DPAT 
      treatment increased depression-like behavior. Concomitantly with the behavioral 
      effects, postnatal treatment with fluoxetine and 8-OH-DPAT decreased the mRNA 
      expression of the GABA(A) receptor alpha3 subunit in the mPFC and ventral hippocampus 
      in adulthood, while 8-OH-DPAT, but not fluoxetine, decreased the mRNA expression 
      of the 5-HT(1A) receptor and BDNF in the mPFC and the GABA(A) receptor alpha2 subunit 
      in the mPFC and ventral hippocampus. On the basis of the correlative changes 
      between behavior and mRNA expression, these results suggest that the GABA(A) 
      receptor alpha3 subunit in the mPFC and ventral hippocampus may regulate anxiety-like 
      behavior. In contrast, depression-like behavior may be regulated by the 5-HT(1A) 
      receptor and BDNF in the mPFC and by the GABA(A) receptor alpha2 subunit in the mPFC 
      and ventral hippocampus. In summary, activation of the 5-HT(1A) receptor during 
      the postnatal period may reduce anxiety levels, but increase depression levels 
      during adulthood via different multiple molecules in the mPFC and ventral 
      hippocampus.
CI  - Copyright (c) 2017 Elsevier Inc. All rights reserved.
FAU - Ishikawa, Chihiro
AU  - Ishikawa C
AD  - Graduate School of Comprehensive Human Sciences, University of Tsukuba, 1-1-1 
      Tennodai, Tsukuba 305-8577, Japan.
FAU - Shiga, Takashi
AU  - Shiga T
AD  - Graduate School of Comprehensive Human Sciences, University of Tsukuba, 1-1-1 
      Tennodai, Tsukuba 305-8577, Japan; Department of Neurobiology, Faculty of 
      Medicine, University of Tsukuba, 1-1-1 Tennodai, Tsukuba 305-8577, Japan. 
      Electronic address: tshiga@md.tsukuba.ac.jp.
LA  - eng
PT  - Comparative Study
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20170505
PL  - England
TA  - Prog Neuropsychopharmacol Biol Psychiatry
JT  - Progress in neuro-psychopharmacology & biological psychiatry
JID - 8211617
RN  - 0 (Brain-Derived Neurotrophic Factor)
RN  - 0 (Receptors, AMPA)
RN  - 0 (Receptors, GABA-A)
RN  - 0 (Serotonin 5-HT1 Receptor Agonists)
RN  - 01K63SUP8D (Fluoxetine)
RN  - 112692-38-3 (Receptor, Serotonin, 5-HT1A)
RN  - 78950-78-4 (8-Hydroxy-2-(di-n-propylamino)tetralin)
SB  - IM
MH  - 8-Hydroxy-2-(di-n-propylamino)tetralin/pharmacology
MH  - Aging/drug effects/*metabolism
MH  - Amygdala/metabolism
MH  - Animals
MH  - Anxiety/*metabolism
MH  - Behavior, Animal/drug effects
MH  - Brain-Derived Neurotrophic Factor/biosynthesis
MH  - Depression/*metabolism
MH  - Fluoxetine/pharmacology
MH  - Hippocampus/metabolism
MH  - Male
MH  - Mice
MH  - Prefrontal Cortex/metabolism
MH  - Receptor, Serotonin, 5-HT1A/biosynthesis/*physiology
MH  - Receptors, AMPA/biosynthesis
MH  - Receptors, GABA-A/biosynthesis
MH  - Serotonin 5-HT1 Receptor Agonists/pharmacology
OTO - NOTNLM
OT  - 5-HT(1A) receptor
OT  - Anxiety
OT  - BDNF
OT  - Depression
OT  - GABA(A) receptor
EDAT- 2017/05/10 06:00
MHDA- 2018/03/10 06:00
CRDT- 2017/05/10 06:00
PHST- 2016/11/15 00:00 [received]
PHST- 2017/04/14 00:00 [revised]
PHST- 2017/04/14 00:00 [accepted]
PHST- 2017/05/10 06:00 [pubmed]
PHST- 2018/03/10 06:00 [medline]
PHST- 2017/05/10 06:00 [entrez]
AID - S0278-5846(16)30362-1 [pii]
AID - 10.1016/j.pnpbp.2017.04.014 [doi]
PST - ppublish
SO  - Prog Neuropsychopharmacol Biol Psychiatry. 2017 Aug 1;78:66-74. doi: 
      10.1016/j.pnpbp.2017.04.014. Epub 2017 May 5.